Critical Data-Based Re-Evaluation of Minocycline as a Putative Specific Microglia InhibitorMoller, T., Bard, F., Bhattacharya, A., Biber, K., Campbell, B., Dale, E., Eder, C., Gan, L., Garden, G. A., Hughes, Z. A., Pearse, D. D., Staal, R. G. W., Sayed, F. A., Wes, P. D. & Boddeke, H. W. G. M., Oct-2016, In : Glia. 64, 10, p. 1788-1794 7 p.
Research output: Contribution to journal › Review article › Academic › peer-review
Minocycline, a second generation broad-spectrum antibiotic, has been frequently postulated to be a "microglia inhibitor." A considerable number of publications have used minocycline as a tool and concluded, after achieving a pharmacological effect, that the effect must be due to "inhibition" of microglia. It is, however, unclear how this "inhibition" is achieved at the molecular and cellular levels. Here, we weigh the evidence whether minocycline is indeed a bona fide microglia inhibitor and discuss how data generated with minocycline should be interpreted.
|Number of pages||7|
|Publication status||Published - Oct-2016|
- microglia, minocycline, inhibitor, lack of specificity, AMYOTROPHIC-LATERAL-SCLEROSIS, SPINAL-CORD-INJURY, INDUCED AUTOIMMUNE HEPATITIS, PRO-INFLAMMATORY MICROGLIA, REGULATED GENE-EXPRESSION, HUNTINGTONS-DISEASE, CYTOKINE SECRETION, MULTIPLE-SCLEROSIS, TRANSGENIC MICE, MOUSE MODEL