Publication

Critical Data-Based Re-Evaluation of Minocycline as a Putative Specific Microglia Inhibitor

Moller, T., Bard, F., Bhattacharya, A., Biber, K., Campbell, B., Dale, E., Eder, C., Gan, L., Garden, G. A., Hughes, Z. A., Pearse, D. D., Staal, R. G. W., Sayed, F. A., Wes, P. D. & Boddeke, H. W. G. M., Oct-2016, In : Glia. 64, 10, p. 1788-1794 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

  • Thomas Moller
  • Frederique Bard
  • Anindya Bhattacharya
  • Knut Biber
  • Brian Campbell
  • Elena Dale
  • Claudia Eder
  • Li Gan
  • Gwenn A. Garden
  • Zoe A. Hughes
  • Damien D. Pearse
  • Roland G. W. Staal
  • Faten A. Sayed
  • Paul D. Wes
  • Hendrikus W. G. M. Boddeke

Minocycline, a second generation broad-spectrum antibiotic, has been frequently postulated to be a "microglia inhibitor." A considerable number of publications have used minocycline as a tool and concluded, after achieving a pharmacological effect, that the effect must be due to "inhibition" of microglia. It is, however, unclear how this "inhibition" is achieved at the molecular and cellular levels. Here, we weigh the evidence whether minocycline is indeed a bona fide microglia inhibitor and discuss how data generated with minocycline should be interpreted.

Original languageEnglish
Pages (from-to)1788-1794
Number of pages7
JournalGlia
Volume64
Issue number10
Publication statusPublished - Oct-2016

    Keywords

  • microglia, minocycline, inhibitor, lack of specificity, AMYOTROPHIC-LATERAL-SCLEROSIS, SPINAL-CORD-INJURY, INDUCED AUTOIMMUNE HEPATITIS, PRO-INFLAMMATORY MICROGLIA, REGULATED GENE-EXPRESSION, HUNTINGTONS-DISEASE, CYTOKINE SECRETION, MULTIPLE-SCLEROSIS, TRANSGENIC MICE, MOUSE MODEL

ID: 32722501