Critical appraisal of oncological safety of stent as bridge to surgery in left-sided obstructing colon cancer; a systematic review and meta-analysisAmelung, F. J., Burghgraef, T. A., Tanis, P. J., van Hooft, J. E., ter Borg, F., Siersema, P. D., Bemelman, W. A. & Consten, E. C. J., Nov-2018, In : Critical Reviews in Oncology/Hematology. 131, p. 66-75 10 p.
Research output: Contribution to journal › Review article › Academic › peer-review
This meta-analysis aims to determine the long-term oncological outcomes of SEMS as bridge to surgery (BTS) versus emergency surgery (ES). A systematic search without restrictions was conducted, and all studies comparing SEMS with ES reporting on long-term outcomes were included. Methodological quality was assessed using the appropriate tools. Twenty-one comparative studies were selected, reporting on 1919 patients. Meta-analysis showed no significant difference regarding three- and five-year overall survival (OR = 0-85 (0.68-1-08) and OR = 1.04 (0.68-1.57), respectively), disease-free survival (OR = 0.96 (0.73-1.26) and OR = 0.86 (0.54-1-36), respectively) and local recurrence rate (OR = 1.32 (0.78-2.23)). Permanent stomas were significantly lower in the SEMS group (OR 0.49 (0-32-0-74)). Sensitivity analysis on three-year survival showed opposite outcomes, with a trend towards worse survival in the SEMS group when only RCTs are taken into account. In conclusion, when in experienced hands, SEMS placement as BTS seems oncologically safe.
|Number of pages||10|
|Journal||Critical Reviews in Oncology/Hematology|
|Publication status||Published - Nov-2018|
- Colon cancer, Colonic obstruction, Stent, SEMS, Emergency surgery, Survival, LONG-TERM OUTCOMES, EXPANDING METALLIC STENTS, LARGE-BOWEL OBSTRUCTION, MALIGNANT COLORECTAL OBSTRUCTION, EMERGENCY-SURGERY, LAPAROSCOPIC APPROACH, ELECTIVE SURGERY, MANAGEMENT, PLACEMENT, PERFORATION