Covering all bases in HIV research: Unveiling a hidden world of viral evolutionVrancken, B., Lequime, S., Theys, K. & Lemey, P., 24-Jun-2010, In : Aids reviews. 12, 2, p. 89-102 14 p.
Research output: Contribution to journal › Review article › Academic › peer-review
The advent of next-generation sequencing technologies has greatly impacted genomic research by providing a means for increasing the amount of sequence information in a cost effective fashion. Among the major next-generation sequencing technologies, the Roche 454 platform has been widely adopted in HIV research. We discuss a broad range of applications of the 454 pyrosequencing platform in the HIV field, with a particular emphasis on antiretroviral therapy and virus-host interaction-related research. We also highlight some of the bioinformatics challenges, as well as advantages and potential limitations of this "deep" sequencing tool, and hint at future research applications.
|Number of pages||14|
|Publication status||Published - 24-Jun-2010|
- Anti-HIV Agents/therapeutic use, Evolution, Molecular, HIV/classification, HIV Infections/drug therapy, Humans, RNA, Viral/genetics, Sequence Analysis, DNA