Could ecosystem management provide a new framework for Alzheimer's disease?Hubin, E., Vanschoenwinkel, B., Broersen, K., De Deyn, P. P., Koedam, N., van Nuland, N. A. & Pauwels, K., Jan-2016, In : Alzheimers & dementia. 12, 1, p. 65-74 10 p.
Research output: Contribution to journal › Article › Academic › peer-review
Alzheimer's disease (AD) is a progressive neurodegenerative brain disorder that involves a plethora of molecular pathways. In the context of therapeutic treatment and biomarker profiling, the amyloid-beta (A beta) peptide constitutes an interesting research avenue that involves interactions within a complex mixture of A beta alloforms and other disease-modifying factors. Here, we explore the potential of an ecosystem paradigm as a novel way to consider AD and A beta dynamics in particular. We discuss the example that the complexity of the A beta network not only exhibits interesting parallels with the functioning of complex systems such as ecosystems but that this analogy can also provide novel insights into the neurobiological phenomena in AD and serve as a communication tool. We propose that combining network medicine with general ecosystem management principles could be a new and holistic approach to understand AD pathology and design novel therapies. (C) 2016 The Authors. Published by Elsevier Inc.
|Number of pages||10|
|Journal||Alzheimers & dementia|
|Publication status||Published - Jan-2016|
- Alzheimer's disease, Amyloid-beta peptide, AD therapy, Ecosystem management, Eutrophication, Spatiotemporal dynamics, A beta alloform, Network medicine, Communication, TRAUMATIC BRAIN-INJURY, EARLY WARNING SIGNALS, BETA PEPTIDE, EPIGENETICS, HYPOTHESIS, IMPAIRMENT, BIOMARKERS, PATHOLOGY, TOXICITY, DEMENTIA