Cost-effectiveness of CBT, SSRI, and CBT+SSRI in the treatment for panic disorder

van Apeldoorn, F. J., Stant, A. D., van Hout, W. J. P. J., Mersch, P. P. A. & den Boer, J. A., Apr-2014, In : Acta Psychiatrica Scandinavica. 129, 4, p. 286-295 10 p.

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The objective of this study was to assess the cost-effectiveness of three empirically supported treatments for panic disorder with or without agoraphobia: cognitive behavioral therapy (CBT), pharmacotherapy using a selective serotonin reuptake inhibitor (SSRI), or the combination of both (CBT+SSRI).


Cost-effectiveness was examined based on the data from a multicenter randomized controlled trial. The Hamilton Anxiety Rating Scale was selected as a primary health outcome measure. Data on costs from a societal perspective (i.e., direct medical, direct non-medical, and indirect non-medical costs) were collected in the study sample (N=150) throughout a 24-month period in which patients received active treatment during the first twelve months and were seen twice for follow-up in the next twelve months.


Total costs were largely influenced by costs of the interventions and productivity losses. The mean total societal costs were lower for CBT as compared to SSRI and CBT+SSRI. Costs of medication use were substantial for both SSRI and CBT+SSRI. When examining the balance between costs and health outcomes, both CBT and CBT+SSRI led to more positive outcomes than SSRI.


Cognitive behavioral therapy is associated with the lowest societal costs. Cognitive behavioral therapy and CBT+SSRI are more cost-effective treatments for panic disorder with or without agoraphobia as compared to SSRI only.

Original languageEnglish
Pages (from-to)286-295
Number of pages10
JournalActa Psychiatrica Scandinavica
Issue number4
Publication statusPublished - Apr-2014


  • agoraphobia, drug treatment, cognitive behavioral therapy, cost-effectiveness analysis, economic evaluation, randomized controlled trial, panic disorder, COGNITIVE-BEHAVIORAL THERAPY, SEROTONIN REUPTAKE INHIBITOR, ECONOMIC EVALUATIONS, CLINICAL-TRIALS, AGORAPHOBIA, EFFICACY, DISEASE

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