Cost-effectiveness of a transitional pharmaceutical care program for patients discharged from the hospital

Karapinar-Çarkıt, F., van der Knaap, R., Bouhannouch, F., Borgsteede, S. D., Janssen, M. J. A., Siegert, C. E. H., Egberts, T. C. G., van den Bemt, P. M. L. A., van Wier, M. F. & Bosmans, J. E., 2017, In : PLoS ONE. 12, 4, 20 p., e0174513.

Research output: Contribution to journalArticleAcademicpeer-review

  • Fatma Karapinar-Çarkıt
  • Ronald van der Knaap
  • Fatiha Bouhannouch
  • Sander D Borgsteede
  • Marjo J A Janssen
  • Carl E H Siegert
  • Toine C G Egberts
  • Patricia M L A van den Bemt
  • Marieke F van Wier
  • Judith E Bosmans

BACKGROUND: To improve continuity of care at hospital admission and discharge and to decrease medication errors pharmaceutical care programs are developed. This study aims to determine the cost-effectiveness of the COACH program in comparison with usual care from a societal perspective.

METHODS: A controlled clinical trial was performed at the Internal Medicine department of a general teaching hospital. All admitted patients using at least one prescription drug were included. The COACH program consisted of medication reconciliation, patient counselling at discharge, and communication to healthcare providers in primary care. The primary outcome was the proportion of patients with an unplanned rehospitalisation within three months after discharge. Also, the number of quality-adjusted life-years (QALYs) was assessed. Cost data were collected using cost diaries. Uncertainty surrounding cost differences and incremental cost-effectiveness ratios between the groups was estimated by bootstrapping.

RESULTS: In the COACH program, 168 patients were included and in usual care 151 patients. There was no significant difference in the proportion of patients with unplanned rehospitalisations (mean difference 0.17%, 95% CI -8.85;8.51), and in QALYs (mean difference -0.0085, 95% CI -0.0170;0.0001). Total costs for the COACH program were non-significantly lower than usual care (-€1160, 95% CI -3168;847). Cost-effectiveness planes showed that the program was not cost-effective compared with usual care for unplanned rehospitalisations and QALYs gained.

CONCLUSION: The COACH program was not cost-effective in comparison with usual care. Future studies should focus on high risk patients and include other outcomes (e.g. adverse drug events) as this may increase the chances of a cost-effective intervention. Dutch trial register NTR1519.

Original languageEnglish
Article numbere0174513
Number of pages20
JournalPLoS ONE
Issue number4
Publication statusPublished - 2017
Externally publishedYes


  • Aged, Aged, 80 and over, Cost-Benefit Analysis, Female, Hospitalization, Hospitals, Teaching, Humans, Male, Medication Reconciliation, Middle Aged, Patient Discharge, Pharmaceutical Services/economics, Program Development, Quality-Adjusted Life Years

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