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Cost-effectiveness model for a specific mixture of prebiotics in The Netherlands

Lenoir-Wijnkoop, I., van Aalderen, W. M. C., Boehm, G., Klaassen, D., Sprikkelman, A. B. & Nuijten, M. J. C., Feb-2012, In : European Journal of Health Economics. 13, 1, p. 101-110 10 p.

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  • Cost-effectiveness model for a specific mixture of prebiotics in The Netherlands

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DOI

  • I. Lenoir-Wijnkoop
  • W. M. C. van Aalderen
  • G. Boehm
  • D. Klaassen
  • A. B. Sprikkelman
  • M. J. C. Nuijten

The objective of this study was to assess the cost-effectiveness of the use of prebiotics for the primary prevention of atopic dermatitis in The Netherlands. A model was constructed using decision analytical techniques. The model was developed to estimate the health economic impact of prebiotic preventive disease management of atopic dermatitis. Data sources used include published literature, clinical trials and official price/tariff lists and national population statistics. The comparator was no supplementation with prebiotics. The primary perspective for conducting the economic evaluation was based on the situation in The Netherlands in 2009. The results show that the use of prebiotics infant formula (IMMUNOFORTISA (R)) leads to an additional cost of a,not sign 51 and an increase in Quality Adjusted Life Years (QALY) of 0.108, when compared with no prebiotics. Consequently, the use of infant formula with a specific mixture of prebiotics results in an incremental cost-effectiveness ratio (ICER) of a,not signA 472. The sensitivity analyses show that the ICER remains in all analyses far below the threshold of a,not sign 20,000/QALY.

This study shows that the favourable health benefit of the use of a specific mixture of prebiotics results in positive short- and long-term health economic benefits. In addition, this study demonstrates that the use of infant formula with a specific mixture of prebiotics is a highly cost-effective way of preventing atopic dermatitis in The Netherlands.

Original languageEnglish
Pages (from-to)101-110
Number of pages10
JournalEuropean Journal of Health Economics
Volume13
Issue number1
Publication statusPublished - Feb-2012
Externally publishedYes

    Keywords

  • Prebiotics cost-effectiveness model, Primary prevention atopic dermatitis, Nutrition economics, QUALITY-OF-LIFE, PLACEBO-CONTROLLED TRIAL, ATOPIC-DERMATITIS, YOUNG-CHILDREN, INITIAL VALIDATION, FOLLOW-UP, ECZEMA, ASTHMA, DISEASE, IMPACT

ID: 71335044