Cost-effectiveness and budget impact of the fixed-dose dual bronchodilator combination tiotropium–olodaterol for patients with COPD in the Netherlands

van Boven, J. F., Kocks, J. W. & Postma, M. J., 1-Oct-2016, In : International Journal of Chronic Obstructive Pulmonary Disease. 11, 1, p. 2191-2201 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

PURPOSE: The fixed-dose dual bronchodilator combination (FDC) of tiotropium and olodaterol showed increased effectiveness regarding lung function and health-related quality of life in patients with chronic obstructive pulmonary disease (COPD) compared with the use of its mono-components. Yet, while effectiveness and safety have been shown, the health economic implication of this treatment is still unknown. The aim of this study was to assess the cost-utility and budget impact of tiotropium-olodaterol FDC in patients with moderate to very severe COPD in the Netherlands.

PATIENTS AND METHODS: A cost-utility study was performed, using an individual-level Markov model. To populate the model, individual patient-level data (age, height, sex, COPD duration, baseline forced expiratory volume in 1 second) were obtained from the tiotropium-olodaterol TOnado trial. In the model, forced expiratory volume in 1 second and patient-level data were extrapolated to utility and survival, and treatment with tiotropium-olodaterol FDC was compared with tiotropium. Cost-utility analysis was performed from the Dutch health care payer's perspective using a 15-year time horizon in the base-case analysis. The standard Dutch discount rates were applied (costs: 4.0%; effects: 1.5%). Both univariate and probabilistic sensitivity analyses were performed. Budget impact was annually assessed over a 5-year time horizon, taking into account different levels of medication adherence.

RESULTS: As a result of cost increases, combined with quality-adjusted life-year (QALY) gains, results showed that tiotropium-olodaterol FDC had an incremental cost-effectiveness ratio of €7,004/QALY. Without discounting, the incremental cost-effectiveness ratio was €5,981/QALY. Results were robust in univariate and probabilistic sensitivity analyses. Budget impact was estimated at €4.3 million over 5 years assuming 100% medication adherence. Scenarios with 40%, 60%, and 80% adherence resulted in lower 5-year incremental cost increases of €1.7, €2.6, and €3.4 million, respectively.

CONCLUSION: Tiotropium-olodaterol FDC can be considered a cost-effective treatment under current Dutch cost-effectiveness thresholds.

Original languageEnglish
Pages (from-to)2191-2201
Number of pages11
JournalInternational Journal of Chronic Obstructive Pulmonary Disease
Issue number1
Publication statusPublished - 1-Oct-2016


  • Budget impact, COPD, Cost-effectiveness, Cost–utility, Health economics, olodaterol plus tiotropium bromide, tiotropium bromide, age distribution, article, chronic obstructive lung disease, cost effectiveness analysis, disease duration, disease exacerbation, disease severity, drug cost, forced expiratory volume, health care cost, human, medication compliance, Netherlands, quality adjusted life year, sex difference, survival rate, treatment duration, treatment outcome

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