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Corticosteroid effects on electrical properties of brain cells: Temporal aspects and role of antiglucocorticoids

Joels, M., Karten, Y., Hesen, W. & deKloet, ER., 1997, In : Psychoneuroendocrinology. 22, Suppl. 1, p. S81-S86 6 p.

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  • Corticosteroid effects on electrical properties of brain cells: Temporal aspects and role of antiglucocorticoids

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DOI

Pyramidal cells in the CAI hippocampal area express both mineralo- and glucocorticoid receptors (MRs and GRs respectively) to which the rat adrenal hormone corticosterone binds effectively. Through activation of these receptors corticosteroids exert a delayed and persistent control over signal transduction in the hippocampus. Many cellular responses are affected by the hormone, including responsiveness to serotonin (5HT) and the cholinergic agent carbachol (CCh). It was found that predominant MR occupation results within hours in small responses to 5HT and to CCh. Concomitant activation of GRs leads to larger transmitter responses. Particularly strong responses to 5HT were observed 1-4 hours after an acute stress; this could be prevented by pretreatment with the antiglucocorticoid RU38486. Steroids also exert a longterm effect on aminergic responses. Chronic exposure to a very high corticosterone dose was found to depress 5HT responses. These data indicate that short-term fluctuations in corticosterone level alter neurotransmitter responses in the hippocampus, a structure involved in mood and cognition. In addition, long-term aberrations in corticosteroid levels, e.g. due to glucocorticoid feedback resistance in association with several stress-related disorders, also change the hippocampal responsiveness to monoamines. Future studies will have to examine the potential of antiglucocorticoids to restore this disturbed neurotransmitter function. (C) 1997 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)S81-S86
Number of pages6
JournalPsychoneuroendocrinology
Volume22
Issue numberSuppl. 1
Publication statusPublished - 1997
Externally publishedYes
Event1st Conference on Cortisol and Anti-Cortisols - CHATEAU DE FILLERVAL, France
Duration: 21-Jun-199623-Jun-1996

Event

1st Conference on Cortisol and Anti-Cortisols

21/06/199623/06/1996

CHATEAU DE FILLERVAL, France

Event: Conference

    Keywords

  • mineralocorticoid receptor, glucocorticoid receptor, serotonin, acetylcholine, hippocampus, electrophysiology, HIPPOCAMPAL CA1 NEURONS, PYRAMIDAL NEURONS, NERVOUS-SYSTEM, MODULATION, RECEPTORS, HORMONES

ID: 66161774