Publication

Coronary calcium scoring with partial volume correction in anthropomorphic thorax phantom and screening chest CT images

Sprem, J., de Vos, B. D., Lessmann, N., van Hamersvelt, R. W., Greuter, M. J. W., de Jong, P. A., Leiner, T., Viergever, M. A. & Isgum, I., 20-Dec-2018, In : PLoS ONE. 13, 12, 20 p., 0209318.

Research output: Contribution to journalArticleAcademicpeer-review

  • Jurica Sprem
  • Bob D. de Vos
  • Nikolas Lessmann
  • Robbert W. van Hamersvelt
  • Marcel J. W. Greuter
  • Pim A. de Jong
  • Tim Leiner
  • Max A. Viergever
  • Ivana Isgum

Introduction

The amount of coronary artery calcium determined in CT scans is a well established predictor of cardiovascular events. However, high interscan variability of coronary calcium quantification may lead to incorrect cardiovascular risk assignment. Partial volume effect contributes to high interscan variability. Hence, we propose a method for coronary calcium quantification employing partial volume correction.

Methods

Two phantoms containing artificial coronary artery calcifications and 293 subject chest CT scans were used. The first and second phantom contained nine calcifications and the second phantom contained three artificial arteries with three calcifications of different volumes, shapes and densities. The first phantom was scanned five times with and without extension rings. The second phantom was scanned three times without and with simulated cardiac motion (10 and 30 mm/s). Chest CT scans were acquired without ECG-synchronization and reconstructed using sharp and soft kernels. Coronary calcifications were annotated employing the clinically used intensity value thresholding (130 HU). Thereafter, a threshold separating each calcification from its background was determined using an Expectation-Maximization algorithm. Finally, for each lesion the partial content of calcification in each voxel was determined depending on its intensity and the determined threshold.

Results

Clinical calcium scoring resulted in overestimation of calcium volume for medium and high density calcifications in the first phantom, and overestimation of calcium volume for high density and underestimation for low density calcifications in the second phantom. With induced motion these effects were further emphasized. The proposed quantification resulted in better accuracy and substantially lower over- and underestimation of calcium volume even in presence of motion. In chest CT, the agreement between calcium scores from the two reconstructions improved when proposed method was used.

Conclusion

Compared with clinical calcium scoring, proposed quantification provides a better estimate of the true calcium volume in phantoms and better agreement in calcium scores between different subject scan reconstructions.

Original languageEnglish
Article number0209318
Number of pages20
JournalPLoS ONE
Volume13
Issue number12
Publication statusPublished - 20-Dec-2018

    Keywords

  • ELECTRON-BEAM CT, ARTERY CALCIUM, COMPUTED-TOMOGRAPHY, HELICAL CT, CALCIFICATION, REPRODUCIBILITY, QUANTIFICATION, MORTALITY, VARIABILITY, DISEASE
Related Datasets
  1. Data: Coronary calcium scoring with partial volume correction in anthropomorphic thorax phantom and screening chest CT images

    Sprem, J. (Creator), de Vos, B. D. (Creator), Lessmann, N. (Creator), van Hamersvelt, R. W. (Creator), Greuter, M. (Creator), de Jong, P. A. (Creator), Leiner, T. (Creator), Viergever, M. A. (Creator), Isgum, I. (Creator), Utrecht University, 10-Dec-2018

    Dataset

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