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Coronary Artery Calcium Imaging in the ROBINSCA Trial: Rationale, Design, and Technical Background

Vonder, M., van der Aalst, C. M., Vliegenthart, R., van Ooijen, P. M. A., Kuijpers, D., Gratama, J. W., de Koning, H. J. & Oudkerk, M., Jan-2018, In : Academic Radiology. 25, 1, p. 118-128 11 p.

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  • Coronary Artery Calcium Imaging in the ROBINSCA Trial

    Final publisher's version, 884 KB, PDF document

DOI

Rationale and Objectives: To describe the rationale, design, and technical background of coronary artery calcium (CAC) imaging in the large-scale population-based cardiovascular disease screening trial (Risk Or Benefit IN Screening for CArdiovascular Diseases [ROBINSCA]).

Materials and Methods: First, literature search was performed to review the logistics, setup, and settings of previously performed CAC imaging studies, and current clinical CAC imaging protocols of participating centers in the ROBINSCA trial were evaluated. A second literature search was performed to evaluate the impact of computed tomography parameter settings on CAC score.

Results: Based on literature reviews and experts opinion an imaging protocol accompanied by data management protocol was created for ROBINSCA. The imaging protocol should consist of a fixed tube voltage, individually tailored tube current setting, mid-diastolic electrocardiography-triggering, fixed field-of-view, fixed reconstruction kernel, fixed slice thickness, overlapping reconstruction and without iterative reconstruction. The analysis of scans is performed with one type and version of CAC scoring software, by two dedicated and experienced researchers. The data management protocol describes the organization of data handling between the coordinating center, participating centers, and core analysis center.

Conclusion: In this paper we describe the rationale and technical considerations to be taken in developing CAC imaging protocol, and we present a detailed protocol that can be implemented for CAC screening purposes.

Original languageEnglish
Pages (from-to)118-128
Number of pages11
JournalAcademic Radiology
Volume25
Issue number1
Publication statusPublished - Jan-2018

    Keywords

  • Coronary artery calcification, outcomes, computed tomography, imaging, screening, RADIATION-DOSE REDUCTION, MULTIDETECTOR COMPUTED-TOMOGRAPHY, HEART-DISEASE EVENTS, HYBRID ITERATIVE RECONSTRUCTION, ELECTRON-BEAM TOMOGRAPHY, FILTERED BACK-PROJECTION, IN-VITRO-ASSESSMENT, DUAL-SOURCE CT, TUBE CURRENT, CARDIOVASCULAR RISK
Related Datasets
  1. ROBINSCA

    Oudkerk, M. (Creator), de Koning, H. (Creator), University of Groningen, 2015

    Dataset

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ID: 47532588