Copper-Catalyzed Asymmetric 1,2-Addition of Grignard Reagents to 3-Acyl 2H-chromenes

Calvo, B. C. & Minnaard, A. J., Dec-2017, In : Synlett. 28, 19, p. 2624-2628 5 p.

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  • Copper-Catalyzed Asymmetric 1,2-Addition

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Enones in which the carbon-carbon double bond is part of the pharmacologically important 2H -chromene (2H-1-benzopyran) nucleus undergo asymmetric copper-catalyzed 1,2-addition of Grignard reagents. High yields and enantiomeric excesses up to 84% are obtained and access to these novel enantio-enriched tertiary alcohols is provided.

Original languageEnglish
Pages (from-to)2624-2628
Number of pages5
Issue number19
Publication statusPublished - Dec-2017


  • asymmetric catalysis, Grignard reagents, copper catalysis, 1,2-addition, 2H-chromenes, ALKYLATION, ALCOHOLS, REDUCTION, KETIMINES, KETONES, ENONES

ID: 53518890