Publication

Coping with Sleep Deprivation: Shifts in Regional Brain Activity and Learning Strategy

Hagewoud, R., Havekes, R., Tiba, P. A., Novati, A., Hogenelst, K., Weinreder, P., Van der Zee, E. A. & Meerlo, P., Nov-2010, In : Sleep. 33, 11, p. 1465-1473 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard

Documents

  • Coping with Sleep Deprivation

    Final publisher's version, 540 KB, PDF document

DOI

Study Objectives: Dissociable cognitive strategies are used for place navigation. Spatial strategies rely on the hippocampus, an area important for flexible integration of novel information. Response strategies are more rigid and involve the dorsal striatum. These memory systems can compensate for each other in case of temporal or permanent damage. Sleep deprivation has adverse effects on hippocampal function. However, whether the striatal memory system can compensate for sleep-deprivation-induced hippocampal impairments is unknown.

Design: With a symmetrical maze paradigm for mice, we examined the effect of sleep deprivation on learning the location of a food reward (training) and on learning that a previously nonrewarded arm was now rewarded (reversal training).

Measurements and Results: Five hours of sleep deprivation after each daily training session did not affect performance during training. However, in contrast with controls, sleep-deprived mice avoided a hippocampus-dependent spatial strategy and preferentially used a striatum-dependent response strategy. In line with this, the training-induced increase in phosphorylation of the transcription factor cAMP response-element binding protein (CREB) shifted from hippocampus to dorsal striatum. Importantly, although sleep-deprived mice performed well during training, performance during reversal training was attenuated, most likely due to rigidity of the striatal system they used.

Conclusions: Together, these findings suggest that the brain compensates for negative effects of sleep deprivation on the hippocampal memory system by promoting the use of a striatal memory system. However, effects of sleep deprivation can still appear later on because the alternative learning mechanisms and brain regions involved may result in reduced flexibility under conditions requiring adaptation of previously formed memories.

Original languageEnglish
Pages (from-to)1465-1473
Number of pages11
JournalSleep
Volume33
Issue number11
Publication statusPublished - Nov-2010

    Keywords

  • sleep, sleep homeostasis, sleep rfunction, sleep loss, sleep deprivation, sleep restriction, sleep disturbance, sleep disruption, chronobiology, circadian rhythmicity, daily rhythms, time of day, cognition, learning, learning strategies, maze learning, spatial learning, spatial navigation, reversal learning, memory formation, memory consolidation, long-term memory, memory adaptation, flexibility, brain , hippocampus, striatum, cAMP response-element binding protein , CREB, CREB phosphorylation

ID: 5226553