Publication

Convenient formulation and application of a supramolecular ureido-pyrimidinone modified poly(ethylene glycol) carrier for intrarenal growth factor delivery

Dankers, P. Y. W., van Luyn, M. J. A., Huizinga-van der Vlag, A., Petersen, A. H., Koerts, J. A., Bosman, A. W. & Popa, E. R., Nov-2015, In : European Polymer Journal. 72, p. 484-493 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

The development of local, intrarenal drug delivery therapies is imperative to induce a therapeutic effect without the requirement of high concentrations of drugs, thereby diminishing systemic side effects. Hydrogels are eminently suitable as drug delivery carriers in soft tissues. Here, we show that a supramolecular hydrogel carrier based on ureido-pyrimidinone (UPy) modified poly(ethylene glycol) can be easily formulated and conveniently be applied to deliver anti-inflammatory and anti-fibrotic growth factor protein BMP7 to the kidney. Short-term, immediate modulation of renal inflammation and extracellular matrix remodelling is shown in a rat model of acute kidney injury. Induction of ischemia/reperfusion injury was followed by renal subcapsular implantation of pristine and BMP7-loaded supramolecular hydrogels. The cortical area under the site of implantation was studied after 3 and 7 days. Subcapsular delivery of only 0.30 mu g BMP7 from these supramolecular hydrogels led to a significant reduction in interstitial inflammatory and myofibroblast cell numbers at the site of implantation. These findings show that local, intrarenal delivery of an anti-inflammatory and anti-fibrotic drug from a supramolecular hydrogel carrier can be effective in the reduction of acute inflammation and incipient fibrosis. (C) 2015 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)484-493
Number of pages10
JournalEuropean Polymer Journal
Volume72
Publication statusPublished - Nov-2015

    Keywords

  • Drug delivery/release, Formulation, Growth factor, Supramolecular hydrogel, Kidney, BONE MORPHOGENETIC PROTEINS, CHRONIC KIDNEY-DISEASE, TRANSIENT NETWORKS, MYOFIBROBLAST, FIBROSIS, RATS, ISCHEMIA/REPERFUSION, FIBROGENESIS, HYDROGELS, INJURY

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