Controlling the activity of quorum sensing autoinducers with lightVan der Berg, J. P., Velema, W. A., Szymanski, W., Driessen, A. J. M. & Feringa, B. L., 2015, In : Chemical Science. 6, 6, p. 3593-3598 6 p.
Research output: Contribution to journal › Article › Academic › peer-review
Bacteria use a communication system, called quorum sensing (QS), to organize into communities and synchronize gene expression to promote virulence and secure survival. Here we report on a proof-of-principle for externally interfering with this bacterial communication system, using light. By employing photoswitchable small molecules, we were able to photocontrol the QS-related bioluminescence in an Escherichia coli reporter strain, and the expression of target QS genes and pyocyanin production in Pseudomonas aeruginosa.
|Number of pages||6|
|Publication status||Published - 2015|
- SMALL-MOLECULE INHIBITORS, TO-CELL COMMUNICATION, PSEUDOMONAS-AERUGINOSA, BIOFILM FORMATION, OPTICAL CONTROL, VISIBLE-LIGHT, RED-LIGHT, PYOCYANIN, BACTERIA, FLUOROAZOBENZENES