Publication

Contributions of Interactions Between Lifestyle and Genetics on Coronary Artery Disease Risk

Said, M. A., van de Vegte, Y. J., Zafar, M. M., van der Ende, M. Y., Raja, G. K., Verweij, N. & van der Harst, P., Sep-2019, In : Current cardiology reports. 21, 9, p. 89 8 p., 89.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Said, M. A., van de Vegte, Y. J., Zafar, M. M., van der Ende, M. Y., Raja, G. K., Verweij, N., & van der Harst, P. (2019). Contributions of Interactions Between Lifestyle and Genetics on Coronary Artery Disease Risk. Current cardiology reports, 21(9), 89. [89]. https://doi.org/10.1007/s11886-019-1177-x

Author

Said, M Abdullah ; van de Vegte, Yordi J ; Zafar, Muhammad Mobeen ; van der Ende, M Yldau ; Raja, Ghazala Kaukab ; Verweij, N ; van der Harst, Pim. / Contributions of Interactions Between Lifestyle and Genetics on Coronary Artery Disease Risk. In: Current cardiology reports. 2019 ; Vol. 21, No. 9. pp. 89.

Harvard

Said, MA, van de Vegte, YJ, Zafar, MM, van der Ende, MY, Raja, GK, Verweij, N & van der Harst, P 2019, 'Contributions of Interactions Between Lifestyle and Genetics on Coronary Artery Disease Risk', Current cardiology reports, vol. 21, no. 9, 89, pp. 89. https://doi.org/10.1007/s11886-019-1177-x

Standard

Contributions of Interactions Between Lifestyle and Genetics on Coronary Artery Disease Risk. / Said, M Abdullah; van de Vegte, Yordi J; Zafar, Muhammad Mobeen; van der Ende, M Yldau; Raja, Ghazala Kaukab; Verweij, N; van der Harst, Pim.

In: Current cardiology reports, Vol. 21, No. 9, 89, 09.2019, p. 89.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Said MA, van de Vegte YJ, Zafar MM, van der Ende MY, Raja GK, Verweij N et al. Contributions of Interactions Between Lifestyle and Genetics on Coronary Artery Disease Risk. Current cardiology reports. 2019 Sep;21(9):89. 89. https://doi.org/10.1007/s11886-019-1177-x


BibTeX

@article{1b685e46c45d4563b7da11f1fa614c21,
title = "Contributions of Interactions Between Lifestyle and Genetics on Coronary Artery Disease Risk",
abstract = "PURPOSE OF THE REVIEW: To summarize current knowledge on interactions between genetic variants and lifestyle factors (G×L) associated with the development of coronary artery disease (CAD) and prioritize future research.RECENT FINDINGS: Genetic risk and combined lifestyle factors and behaviors have a log-additive effect on the risk of developing CAD. First, we describe genetic and lifestyle factors associated with CAD and then focus on G×L interactions. The majority of G×L interaction studies are small-scale candidate gene studies that lack replication and therefore provide spurious results. Only a few studies, of which most use genetic risk scores or genome-wide approaches to test interactions, are robust in number and analysis strategy. These studies provide evidence for the existence of G×L interactions in the development of CAD. Further G×L interactions studies are important as they contribute to our understanding of disease pathophysiology and possibly provide insights for improving interventions or personalized recommendations.",
keywords = "Genetics, Lifestyle, Coronary artery disease, Genetic lifestyle interactions, Genome-wide association studies, Genetic risk scores, DOSE-RESPONSE METAANALYSIS, TERM COFFEE CONSUMPTION, HEART-DISEASE, CARDIOVASCULAR-DISEASE, PHYSICAL-ACTIVITY, MYOCARDIAL-INFARCTION, ALCOHOL-CONSUMPTION, CIGARETTE-SMOKING, ASSOCIATION, INDIVIDUALS",
author = "Said, {M Abdullah} and {van de Vegte}, {Yordi J} and Zafar, {Muhammad Mobeen} and {van der Ende}, {M Yldau} and Raja, {Ghazala Kaukab} and N Verweij and {van der Harst}, Pim",
year = "2019",
month = "9",
doi = "10.1007/s11886-019-1177-x",
language = "English",
volume = "21",
pages = "89",
journal = "Current cardiology reports",
issn = "1523-3782",
publisher = "SPRINGER",
number = "9",

}

RIS

TY - JOUR

T1 - Contributions of Interactions Between Lifestyle and Genetics on Coronary Artery Disease Risk

AU - Said, M Abdullah

AU - van de Vegte, Yordi J

AU - Zafar, Muhammad Mobeen

AU - van der Ende, M Yldau

AU - Raja, Ghazala Kaukab

AU - Verweij, N

AU - van der Harst, Pim

PY - 2019/9

Y1 - 2019/9

N2 - PURPOSE OF THE REVIEW: To summarize current knowledge on interactions between genetic variants and lifestyle factors (G×L) associated with the development of coronary artery disease (CAD) and prioritize future research.RECENT FINDINGS: Genetic risk and combined lifestyle factors and behaviors have a log-additive effect on the risk of developing CAD. First, we describe genetic and lifestyle factors associated with CAD and then focus on G×L interactions. The majority of G×L interaction studies are small-scale candidate gene studies that lack replication and therefore provide spurious results. Only a few studies, of which most use genetic risk scores or genome-wide approaches to test interactions, are robust in number and analysis strategy. These studies provide evidence for the existence of G×L interactions in the development of CAD. Further G×L interactions studies are important as they contribute to our understanding of disease pathophysiology and possibly provide insights for improving interventions or personalized recommendations.

AB - PURPOSE OF THE REVIEW: To summarize current knowledge on interactions between genetic variants and lifestyle factors (G×L) associated with the development of coronary artery disease (CAD) and prioritize future research.RECENT FINDINGS: Genetic risk and combined lifestyle factors and behaviors have a log-additive effect on the risk of developing CAD. First, we describe genetic and lifestyle factors associated with CAD and then focus on G×L interactions. The majority of G×L interaction studies are small-scale candidate gene studies that lack replication and therefore provide spurious results. Only a few studies, of which most use genetic risk scores or genome-wide approaches to test interactions, are robust in number and analysis strategy. These studies provide evidence for the existence of G×L interactions in the development of CAD. Further G×L interactions studies are important as they contribute to our understanding of disease pathophysiology and possibly provide insights for improving interventions or personalized recommendations.

KW - Genetics

KW - Lifestyle

KW - Coronary artery disease

KW - Genetic lifestyle interactions

KW - Genome-wide association studies

KW - Genetic risk scores

KW - DOSE-RESPONSE METAANALYSIS

KW - TERM COFFEE CONSUMPTION

KW - HEART-DISEASE

KW - CARDIOVASCULAR-DISEASE

KW - PHYSICAL-ACTIVITY

KW - MYOCARDIAL-INFARCTION

KW - ALCOHOL-CONSUMPTION

KW - CIGARETTE-SMOKING

KW - ASSOCIATION

KW - INDIVIDUALS

U2 - 10.1007/s11886-019-1177-x

DO - 10.1007/s11886-019-1177-x

M3 - Review article

VL - 21

SP - 89

JO - Current cardiology reports

JF - Current cardiology reports

SN - 1523-3782

IS - 9

M1 - 89

ER -

ID: 93330450