Publication

Contributions of Interactions Between Lifestyle and Genetics on Coronary Artery Disease Risk

Said, M. A., van de Vegte, Y. J., Zafar, M. M., van der Ende, M. Y., Raja, G. K., Verweij, N. & van der Harst, P., Sep-2019, In : Current cardiology reports. 21, 9, p. 89 8 p., 89.

Research output: Contribution to journalReview articleAcademicpeer-review

PURPOSE OF THE REVIEW: To summarize current knowledge on interactions between genetic variants and lifestyle factors (G×L) associated with the development of coronary artery disease (CAD) and prioritize future research.

RECENT FINDINGS: Genetic risk and combined lifestyle factors and behaviors have a log-additive effect on the risk of developing CAD. First, we describe genetic and lifestyle factors associated with CAD and then focus on G×L interactions. The majority of G×L interaction studies are small-scale candidate gene studies that lack replication and therefore provide spurious results. Only a few studies, of which most use genetic risk scores or genome-wide approaches to test interactions, are robust in number and analysis strategy. These studies provide evidence for the existence of G×L interactions in the development of CAD. Further G×L interactions studies are important as they contribute to our understanding of disease pathophysiology and possibly provide insights for improving interventions or personalized recommendations.

Original languageEnglish
Article number89
Pages (from-to)89
Number of pages8
JournalCurrent cardiology reports
Volume21
Issue number9
Publication statusPublished - Sep-2019

    Keywords

  • Genetics, Lifestyle, Coronary artery disease, Genetic lifestyle interactions, Genome-wide association studies, Genetic risk scores, DOSE-RESPONSE METAANALYSIS, TERM COFFEE CONSUMPTION, HEART-DISEASE, CARDIOVASCULAR-DISEASE, PHYSICAL-ACTIVITY, MYOCARDIAL-INFARCTION, ALCOHOL-CONSUMPTION, CIGARETTE-SMOKING, ASSOCIATION, INDIVIDUALS

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