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Connecting G protein signaling to chemoattractant-mediated cell polarity and cytoskeletal reorganization

Liu, Y., Lacal, J., Firtel, R. A. & Kortholt, A., 2018, In : Small GTPases. 9, 4, p. 360-364 5 p.

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The directional movement towards extracellular chemical gradients, a process called chemotaxis, is an important property of cells. Central to eukaryotic chemotaxis is the molecular mechanism by which chemoattractant-mediated activation of G-protein coupled receptors (GPCRs) induces symmetry breaking in the activated downstream signaling pathways. Studies with mainly Dictyostelium and mammalian neutrophils as experimental systems have shown that chemotaxis is mediated by a complex network of signaling pathways. Recently, several labs have used extensive and efficient proteomic approaches to further unravel this dynamic signaling network. Together these studies showed the critical role of the interplay between heterotrimeric G-protein subunits and monomeric G proteins in regulating cytoskeletal rearrangements during chemotaxis. Here we highlight how these proteomic studies have provided greater insight into the mechanisms by which the heterotrimeric G protein cycle is regulated, how heterotrimeric G proteins-induced symmetry breaking is mediated through small G protein signaling, and how symmetry breaking in G protein signaling subsequently induces cytoskeleton rearrangements and cell migration.

Original languageEnglish
Pages (from-to)360-364
Number of pages5
JournalSmall GTPases
Volume9
Issue number4
Early online date14-Oct-2017
Publication statusPublished - 2018

    Keywords

  • chemotaxis, cytoskeleton rearrangement, Dictyostelium, GPCRs, heterotrimeric G proteins, proteomics, Ras, Rap, small G proteins, TORC2

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