Publication
Compounds Interfering with Embryonic Lethal Abnormal Vision (ELAV) Protein-RNA Complexes: An Avenue for Discovering New Drugs
Nasti, R., Rossi, D., Amadio, M., Pascale, A., Unver, M. Y., Hirsch, A. K. H. & Collina, S., 26-Oct-2017, In : Journal of Medicinal Chemistry. 60, 20, p. 8257-8267 11 p.Research output: Contribution to journal › Article › Academic › peer-review

Documents
- Compounds Interfering with Embryonic Lethal Abnormal Vision (ELAV) Protein − RNA Complexes: An Avenue for Discovering New Drugs
Final publisher's version, 2.55 MB, PDF document
DOI
RNA-binding proteins play a key role in post-transcriptional processes. Among these proteins, embryonic lethal abnormal vision (ELAV) proteins are among the best described. ELAV proteins predominantly act as positive regulators of gene expression, and their dysregulation is involved in several pathologies, such as cancer, inflammation, and neurodegenerative diseases. Only a few structurally unrelated compounds interfering with ELAV protein-mRNA complexes have been identified by applying high-throughput screening approaches. Considering the structural diversity of the compounds discovered so far and the different techniques employed for screening their ability to interfere with ELAV protein-mRNA complexes, drawing conclusions from structure-activity relationships remains a challenge. We performed docking studies to understand the interactions of compounds reported over the past decade to be inhibitors of ELAV proteins and to evaluate the potential of computer-aided drug design to target this family of proteins for further drug discovery.
Original language | English |
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Pages (from-to) | 8257-8267 |
Number of pages | 11 |
Journal | Journal of Medicinal Chemistry |
Volume | 60 |
Issue number | 20 |
Publication status | Published - 26-Oct-2017 |
- AU-RICH ELEMENT, MESSENGER-RNA, BINDING PROTEINS, ALZHEIMERS-DISEASE, RECOGNITION MOTIF, NERVOUS-SYSTEM, HUR, CANCER, DROSOPHILA, IDENTIFICATION
Keywords
ID: 50081058