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Compositions and methods for treating senescence-associated diseases and disorders.

Laberge, R-M., Campisi, J., Davalos, A., Lopez-Dominguez, J. A., Demaria, M., David, N., Vasserot, A. P., Baker, D. J., Childs, B. G., Kirkland, J. L., Tchkonia, T., van Deursen, J. M. A. & Zhu, Y., 12-Jan-2017, Patent No. WO2017008060, Priority date 8-Jul-2015

Research output: PatentProfessional

  • Remi-Martin Laberge (Inventor)
  • Judith Campisi (Inventor)
  • Albert Davalos (Inventor)
  • Jose Alberto Lopez-Dominguez (Inventor)
  • Marco Demaria (Inventor)
  • Nathaniel David (Inventor)
  • Alain Philippe Vasserot (Inventor)
  • Darren J. Baker (Inventor)
  • Bennett G. Childs (Inventor)
  • James L. Kirkland (Inventor)
  • Tamar Tchkonia (Inventor)
  • Jan M. A. van Deursen (Inventor)
  • Yi Zhu (Inventor)
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders. Also included herein are methods for extending lifespan.
Original languageEnglish
Patent numberWO2017008060
Priority date08/07/2015
Publication statusPublished - 12-Jan-2017

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