Compositions and methods for treating senescence-associated diseases and disorders.Laberge, R-M., Campisi, J., Davalos, A., Lopez-Dominguez, J. A., Demaria, M., David, N., Vasserot, A. P., Baker, D. J., Childs, B. G., Kirkland, J. L., Tchkonia, T., van Deursen, J. M. A. & Zhu, Y., 12-Jan-2017, Patent No. WO2017008060, Priority date 8-Jul-2015
Research output: Patent › Professional
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders. Also included herein are methods for extending lifespan.
|Publication status||Published - 12-Jan-2017|