Publication

Complex Molecules That Fold Like Proteins Can Emerge Spontaneously

Liu, B., Pappas, C. G., Zangrando, E., Demitri, N., Chmielewski, P. J. & Otto, S., 30-Jan-2019, In : Journal of the American Chemical Society. 141, 4, p. 1685-1689 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Liu, B., Pappas, C. G., Zangrando, E., Demitri, N., Chmielewski, P. J., & Otto, S. (2019). Complex Molecules That Fold Like Proteins Can Emerge Spontaneously. Journal of the American Chemical Society, 141(4), 1685-1689. https://doi.org/10.1021/jacs.8b11698

Author

Liu, Bin ; Pappas, Charalampos G ; Zangrando, Ennio ; Demitri, Nicola ; Chmielewski, Piotr J ; Otto, Sijbren. / Complex Molecules That Fold Like Proteins Can Emerge Spontaneously. In: Journal of the American Chemical Society. 2019 ; Vol. 141, No. 4. pp. 1685-1689.

Harvard

Liu, B, Pappas, CG, Zangrando, E, Demitri, N, Chmielewski, PJ & Otto, S 2019, 'Complex Molecules That Fold Like Proteins Can Emerge Spontaneously', Journal of the American Chemical Society, vol. 141, no. 4, pp. 1685-1689. https://doi.org/10.1021/jacs.8b11698

Standard

Complex Molecules That Fold Like Proteins Can Emerge Spontaneously. / Liu, Bin; Pappas, Charalampos G; Zangrando, Ennio; Demitri, Nicola; Chmielewski, Piotr J; Otto, Sijbren.

In: Journal of the American Chemical Society, Vol. 141, No. 4, 30.01.2019, p. 1685-1689.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Liu B, Pappas CG, Zangrando E, Demitri N, Chmielewski PJ, Otto S. Complex Molecules That Fold Like Proteins Can Emerge Spontaneously. Journal of the American Chemical Society. 2019 Jan 30;141(4):1685-1689. https://doi.org/10.1021/jacs.8b11698


BibTeX

@article{48ad4f047da54a5e8e2610673d8e714e,
title = "Complex Molecules That Fold Like Proteins Can Emerge Spontaneously",
abstract = "Folding can bestow macromolecules with various properties, as evident from nature's proteins. Until now complex folded molecules are the product either of evolution or of an elaborate process of design and synthesis. We now show that molecules that fold in a well-defined architecture of substantial complexity can emerge autonomously and selectively from a simple precursor. Specifically, we have identified a self-synthesizing macrocyclic foldamer with a complex and unprecedented secondary and tertiary structure that constructs itself highly selectively from 15 identical peptide-nucleobase subunits, using a dynamic combinatorial chemistry approach. Folding of the structure drives its synthesis in 95{\%} yield from a mixture of interconverting molecules of different ring sizes in a one-step process. Single-crystal X-ray crystallography and NMR reveal a folding pattern based on an intricate network of noncovalent interactions involving residues spaced apart widely in the linear sequence. These results establish dynamic combinatorial chemistry as a powerful approach to developing synthetic molecules with folding motifs of a complexity that goes well beyond that accessible with current design approaches. The fact that such molecules can form autonomously implies that they may have played a role in the origin of life at earlier stages than previously thought possible.",
author = "Bin Liu and Pappas, {Charalampos G} and Ennio Zangrando and Nicola Demitri and Chmielewski, {Piotr J} and Sijbren Otto",
year = "2019",
month = "1",
day = "30",
doi = "10.1021/jacs.8b11698",
language = "English",
volume = "141",
pages = "1685--1689",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "AMER CHEMICAL SOC",
number = "4",

}

RIS

TY - JOUR

T1 - Complex Molecules That Fold Like Proteins Can Emerge Spontaneously

AU - Liu, Bin

AU - Pappas, Charalampos G

AU - Zangrando, Ennio

AU - Demitri, Nicola

AU - Chmielewski, Piotr J

AU - Otto, Sijbren

PY - 2019/1/30

Y1 - 2019/1/30

N2 - Folding can bestow macromolecules with various properties, as evident from nature's proteins. Until now complex folded molecules are the product either of evolution or of an elaborate process of design and synthesis. We now show that molecules that fold in a well-defined architecture of substantial complexity can emerge autonomously and selectively from a simple precursor. Specifically, we have identified a self-synthesizing macrocyclic foldamer with a complex and unprecedented secondary and tertiary structure that constructs itself highly selectively from 15 identical peptide-nucleobase subunits, using a dynamic combinatorial chemistry approach. Folding of the structure drives its synthesis in 95% yield from a mixture of interconverting molecules of different ring sizes in a one-step process. Single-crystal X-ray crystallography and NMR reveal a folding pattern based on an intricate network of noncovalent interactions involving residues spaced apart widely in the linear sequence. These results establish dynamic combinatorial chemistry as a powerful approach to developing synthetic molecules with folding motifs of a complexity that goes well beyond that accessible with current design approaches. The fact that such molecules can form autonomously implies that they may have played a role in the origin of life at earlier stages than previously thought possible.

AB - Folding can bestow macromolecules with various properties, as evident from nature's proteins. Until now complex folded molecules are the product either of evolution or of an elaborate process of design and synthesis. We now show that molecules that fold in a well-defined architecture of substantial complexity can emerge autonomously and selectively from a simple precursor. Specifically, we have identified a self-synthesizing macrocyclic foldamer with a complex and unprecedented secondary and tertiary structure that constructs itself highly selectively from 15 identical peptide-nucleobase subunits, using a dynamic combinatorial chemistry approach. Folding of the structure drives its synthesis in 95% yield from a mixture of interconverting molecules of different ring sizes in a one-step process. Single-crystal X-ray crystallography and NMR reveal a folding pattern based on an intricate network of noncovalent interactions involving residues spaced apart widely in the linear sequence. These results establish dynamic combinatorial chemistry as a powerful approach to developing synthetic molecules with folding motifs of a complexity that goes well beyond that accessible with current design approaches. The fact that such molecules can form autonomously implies that they may have played a role in the origin of life at earlier stages than previously thought possible.

U2 - 10.1021/jacs.8b11698

DO - 10.1021/jacs.8b11698

M3 - Article

VL - 141

SP - 1685

EP - 1689

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 4

ER -

ID: 92806158