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Complement Activation Is Involved in Renal Damage in Human Antineutrophil Cytoplasmic Autoantibody Associated Pauci-Immune Vasculitis

Xing, G., Chen, M., Liu, G., Heeringa, P., Zhang, J., Zheng, X., Jie, E., Kallenberg, C. G. M. & Zhao, M., May-2009, In : Journal of Clinical Immunology. 29, 3, p. 282-291 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Guang-qun Xing
  • Min Chen
  • Gang Liu
  • Peter Heeringa
  • Jun-jun Zhang
  • Xin Zheng
  • E. Jie
  • Cees G. M. Kallenberg
  • Ming-hui Zhao

This study was to investigate the evidence for complement activation in renal biopsy specimens of patients with myeloperoxidase (MPO)-antineutrophil cytoplasmic autoantibody (ANCA)-associated pauci-immune vasculitis.

Renal biopsy specimens from seven patients with MPO-ANCA positive pauci-immune necrotizing crescentic glomerulonephritis (NCGN) were used to detect the staining of membrane attack complex (MAC), C3d, C4d, mannose-binding lectin (MBL), factor B and factor P using immunohistochemistry and immunofluorescence. Renal tissue from seven patients with minimal change disease (MCD) and two normal renal tissue were used as controls.

MAC, C3d, factor B and factor P could be detected in glomeruli and small blood vessels with active vasculitis of patients with pauci-immune AAV, but not or scarcely in patients with MCD and in normal renal tissue. C3d and factor B co-localized with MAC, factor P colocalized with C3d. MBL and C4d were not detected in patients with AAV.

The alternative pathway of the complement system is involved in renal damage of human pauci-immune AAV.

Original languageEnglish
Pages (from-to)282-291
Number of pages10
JournalJournal of Clinical Immunology
Volume29
Issue number3
Publication statusPublished - May-2009

    Keywords

  • ANCA, complement, histopathology, myeloperoxidase, pauci-immune, vasculitis, ANCA-ASSOCIATED VASCULITIS, LECTIN PATHWAY, CRESCENTIC GLOMERULONEPHRITIS, DEPOSITS, DISEASE, PATHOGENESIS, EXPRESSION, ANTIBODIES, NEPHRITIS, BIOLOGY

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