Publication

Complement Activation in Autoimmune Bullous Dermatoses: A Comprehensive Review

Edwards, G., Diercks, G. F. H., Seelen, M. A. J., Horvath, B., van Doorn, M. B. A. & Damman, J., 26-Jun-2019, In : Frontiers in Immunology. 10, 8 p., 1477.

Research output: Contribution to journalReview articleAcademicpeer-review

Autoimmune bullous dermatoses (AIBD) are characterized by circulating autoantibodies that are either directed against epidermal antigens or deposited as immune complexes in the basement membrane zone (BMZ). The complement system (CS) can be activated by autoantibodies, thereby triggering activation of specific complement pathways. Local complement activation induces a pathogenic inflammatory response that eventually results in the formation of a sub- or intraepidermal blister. Deposition of complement components is routinely used as a diagnostic marker for AIBD. Knowledge from different animal models mimicking AIBD and deposition of complement components in human skin biopsies provides more insight into the role of complement in the pathogenesis of the different AIBD. This review outlines the role of the CS in several AIBD including bullous pemphigoid, epidermolysis bullosa acquisita, mucous membrane pemphigoid (MMP), pemphigus, linear IgA-disease, and dermatitis herpetiformis. We also discuss potential therapeutic approaches targeting key complement components, pathways and pathogenic complement-mediated events.

Original languageEnglish
Article number1477
Number of pages8
JournalFrontiers in Immunology
Volume10
Publication statusPublished - 26-Jun-2019

    Keywords

  • complement, auto-immune bullous dermatosis, bullous pemphigod, epidermolysis bullosa acquisita, mucus membrane pemphigoid, pemphigus, linear IgA bullous dermatoses, dermatitis herpetiformis, MEMBRANE ATTACK COMPLEX, MANNAN-BINDING LECTIN, FORMALIN-FIXED TISSUE, PASSIVE TRANSFER, PEMPHIGUS-VULGARIS, C4D IMMUNOHISTOCHEMISTRY, SUBEPIDERMAL BLISTERS, ALTERNATIVE PATHWAY, MONOCLONAL-ANTIBODY, XVII COLLAGEN

View graph of relations

Download statistics

No data available

ID: 93754978