Publication

Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

Sikdar, S., Joehanes, R., Joubert, B. R., Xu, C-J., Vives-Usano, M., Rezwan, F. I., Felix, J. F., Ward, J. M., Guan, W., Richmond, R. C., Brody, J. A., Küpers, L. K., Baïz, N., Håberg, S. E., Smith, J. A., Reese, S. E., Aslibekyan, S., Hoyo, C., Dhingra, R., Markunas, C. A., Xu, T., Reynolds, L. M., Just, A. C., Mandaviya, P. R., Ghantous, A., Bennett, B. D., Wang, T., The BIOS Consortium, Bakulski, K. M., Melen, E., Zhao, S., Jin, J., Herceg, Z., Meurs, J. V., Taylor, J. A., Baccarelli, A. A., Murphy, S. K., Liu, Y., Munthe-Kaas, M. C., Deary, I. J., Nystad, W., Waldenberger, M., Annesi-Maesano, I., Conneely, K., Jaddoe, V. W., Arnett, D., Snieder, H., Kardia, S. L., Relton, C. L., Ong, K. K., Ewart, S., Moreno-Macias, H., Romieu, I., Sotoodehnia, N., Fornage, M., Motsinger-Reif, A., Koppelman, G. H., Bustamante, M., Levy, D. & London, S. J., Oct-2019, In : Epigenomics. 11, 13, p. 1487-1500 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Sikdar, S., Joehanes, R., Joubert, B. R., Xu, C-J., Vives-Usano, M., Rezwan, F. I., Felix, J. F., Ward, J. M., Guan, W., Richmond, R. C., Brody, J. A., Küpers, L. K., Baïz, N., Håberg, S. E., Smith, J. A., Reese, S. E., Aslibekyan, S., Hoyo, C., Dhingra, R., ... London, S. J. (2019). Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. Epigenomics, 11(13), 1487-1500. https://doi.org/10.2217/epi-2019-0066

Author

Sikdar, Sinjini ; Joehanes, Roby ; Joubert, Bonnie R ; Xu, Cheng-Jian ; Vives-Usano, Marta ; Rezwan, Faisal I ; Felix, Janine F ; Ward, James M ; Guan, Weihua ; Richmond, Rebecca C ; Brody, Jennifer A ; Küpers, Leanne K ; Baïz, Nour ; Håberg, Siri E ; Smith, Jennifer A ; Reese, Sarah E ; Aslibekyan, Stella ; Hoyo, Cathrine ; Dhingra, Radhika ; Markunas, Christina A ; Xu, Tao ; Reynolds, Lindsay M ; Just, Allan C ; Mandaviya, Pooja R ; Ghantous, Akram ; Bennett, Brian D ; Wang, Tianyuan ; The BIOS Consortium ; Bakulski, Kelly M ; Melen, Erik ; Zhao, Shanshan ; Jin, Jianping ; Herceg, Zdenko ; Meurs, Joyce van ; Taylor, Jack A ; Baccarelli, Andrea A ; Murphy, Susan K ; Liu, Yongmei ; Munthe-Kaas, Monica Cheng ; Deary, Ian J ; Nystad, Wenche ; Waldenberger, Melanie ; Annesi-Maesano, Isabella ; Conneely, Karen ; Jaddoe, Vincent Wv ; Arnett, Donna ; Snieder, Harold ; Kardia, Sharon Lr ; Relton, Caroline L ; Ong, Ken K ; Ewart, Susan ; Moreno-Macias, Hortensia ; Romieu, Isabelle ; Sotoodehnia, Nona ; Fornage, Myriam ; Motsinger-Reif, Alison ; Koppelman, Gerard H ; Bustamante, Mariona ; Levy, Daniel ; London, Stephanie J. / Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. In: Epigenomics. 2019 ; Vol. 11, No. 13. pp. 1487-1500.

Harvard

Sikdar, S, Joehanes, R, Joubert, BR, Xu, C-J, Vives-Usano, M, Rezwan, FI, Felix, JF, Ward, JM, Guan, W, Richmond, RC, Brody, JA, Küpers, LK, Baïz, N, Håberg, SE, Smith, JA, Reese, SE, Aslibekyan, S, Hoyo, C, Dhingra, R, Markunas, CA, Xu, T, Reynolds, LM, Just, AC, Mandaviya, PR, Ghantous, A, Bennett, BD, Wang, T, The BIOS Consortium, Bakulski, KM, Melen, E, Zhao, S, Jin, J, Herceg, Z, Meurs, JV, Taylor, JA, Baccarelli, AA, Murphy, SK, Liu, Y, Munthe-Kaas, MC, Deary, IJ, Nystad, W, Waldenberger, M, Annesi-Maesano, I, Conneely, K, Jaddoe, VW, Arnett, D, Snieder, H, Kardia, SL, Relton, CL, Ong, KK, Ewart, S, Moreno-Macias, H, Romieu, I, Sotoodehnia, N, Fornage, M, Motsinger-Reif, A, Koppelman, GH, Bustamante, M, Levy, D & London, SJ 2019, 'Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking', Epigenomics, vol. 11, no. 13, pp. 1487-1500. https://doi.org/10.2217/epi-2019-0066

Standard

Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. / Sikdar, Sinjini; Joehanes, Roby; Joubert, Bonnie R; Xu, Cheng-Jian; Vives-Usano, Marta; Rezwan, Faisal I; Felix, Janine F; Ward, James M; Guan, Weihua; Richmond, Rebecca C; Brody, Jennifer A; Küpers, Leanne K; Baïz, Nour; Håberg, Siri E; Smith, Jennifer A; Reese, Sarah E; Aslibekyan, Stella; Hoyo, Cathrine; Dhingra, Radhika; Markunas, Christina A; Xu, Tao; Reynolds, Lindsay M; Just, Allan C; Mandaviya, Pooja R; Ghantous, Akram; Bennett, Brian D; Wang, Tianyuan; The BIOS Consortium; Bakulski, Kelly M; Melen, Erik; Zhao, Shanshan; Jin, Jianping; Herceg, Zdenko; Meurs, Joyce van; Taylor, Jack A; Baccarelli, Andrea A; Murphy, Susan K; Liu, Yongmei; Munthe-Kaas, Monica Cheng; Deary, Ian J; Nystad, Wenche; Waldenberger, Melanie; Annesi-Maesano, Isabella; Conneely, Karen; Jaddoe, Vincent Wv; Arnett, Donna; Snieder, Harold; Kardia, Sharon Lr; Relton, Caroline L; Ong, Ken K; Ewart, Susan; Moreno-Macias, Hortensia; Romieu, Isabelle; Sotoodehnia, Nona; Fornage, Myriam; Motsinger-Reif, Alison; Koppelman, Gerard H; Bustamante, Mariona; Levy, Daniel; London, Stephanie J.

In: Epigenomics, Vol. 11, No. 13, 10.2019, p. 1487-1500.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Sikdar S, Joehanes R, Joubert BR, Xu C-J, Vives-Usano M, Rezwan FI et al. Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. Epigenomics. 2019 Oct;11(13):1487-1500. https://doi.org/10.2217/epi-2019-0066


BibTeX

@article{94220d8193934ea38f65a85aa7657337,
title = "Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking",
abstract = "Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.",
author = "Sinjini Sikdar and Roby Joehanes and Joubert, {Bonnie R} and Cheng-Jian Xu and Marta Vives-Usano and Rezwan, {Faisal I} and Felix, {Janine F} and Ward, {James M} and Weihua Guan and Richmond, {Rebecca C} and Brody, {Jennifer A} and K{\"u}pers, {Leanne K} and Nour Ba{\"i}z and H{\aa}berg, {Siri E} and Smith, {Jennifer A} and Reese, {Sarah E} and Stella Aslibekyan and Cathrine Hoyo and Radhika Dhingra and Markunas, {Christina A} and Tao Xu and Reynolds, {Lindsay M} and Just, {Allan C} and Mandaviya, {Pooja R} and Akram Ghantous and Bennett, {Brian D} and Tianyuan Wang and {The BIOS Consortium} and Bakulski, {Kelly M} and Erik Melen and Shanshan Zhao and Jianping Jin and Zdenko Herceg and Meurs, {Joyce van} and Taylor, {Jack A} and Baccarelli, {Andrea A} and Murphy, {Susan K} and Yongmei Liu and Munthe-Kaas, {Monica Cheng} and Deary, {Ian J} and Wenche Nystad and Melanie Waldenberger and Isabella Annesi-Maesano and Karen Conneely and Jaddoe, {Vincent Wv} and Donna Arnett and Harold Snieder and Kardia, {Sharon Lr} and Relton, {Caroline L} and Ong, {Ken K} and Susan Ewart and Hortensia Moreno-Macias and Isabelle Romieu and Nona Sotoodehnia and Myriam Fornage and Alison Motsinger-Reif and Koppelman, {Gerard H} and Mariona Bustamante and Daniel Levy and London, {Stephanie J}",
year = "2019",
month = oct,
doi = "10.2217/epi-2019-0066",
language = "English",
volume = "11",
pages = "1487--1500",
journal = "Epigenomics",
issn = "1750-1911",
publisher = "FUTURE MEDICINE LTD",
number = "13",

}

RIS

TY - JOUR

T1 - Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

AU - Sikdar, Sinjini

AU - Joehanes, Roby

AU - Joubert, Bonnie R

AU - Xu, Cheng-Jian

AU - Vives-Usano, Marta

AU - Rezwan, Faisal I

AU - Felix, Janine F

AU - Ward, James M

AU - Guan, Weihua

AU - Richmond, Rebecca C

AU - Brody, Jennifer A

AU - Küpers, Leanne K

AU - Baïz, Nour

AU - Håberg, Siri E

AU - Smith, Jennifer A

AU - Reese, Sarah E

AU - Aslibekyan, Stella

AU - Hoyo, Cathrine

AU - Dhingra, Radhika

AU - Markunas, Christina A

AU - Xu, Tao

AU - Reynolds, Lindsay M

AU - Just, Allan C

AU - Mandaviya, Pooja R

AU - Ghantous, Akram

AU - Bennett, Brian D

AU - Wang, Tianyuan

AU - The BIOS Consortium, null

AU - Bakulski, Kelly M

AU - Melen, Erik

AU - Zhao, Shanshan

AU - Jin, Jianping

AU - Herceg, Zdenko

AU - Meurs, Joyce van

AU - Taylor, Jack A

AU - Baccarelli, Andrea A

AU - Murphy, Susan K

AU - Liu, Yongmei

AU - Munthe-Kaas, Monica Cheng

AU - Deary, Ian J

AU - Nystad, Wenche

AU - Waldenberger, Melanie

AU - Annesi-Maesano, Isabella

AU - Conneely, Karen

AU - Jaddoe, Vincent Wv

AU - Arnett, Donna

AU - Snieder, Harold

AU - Kardia, Sharon Lr

AU - Relton, Caroline L

AU - Ong, Ken K

AU - Ewart, Susan

AU - Moreno-Macias, Hortensia

AU - Romieu, Isabelle

AU - Sotoodehnia, Nona

AU - Fornage, Myriam

AU - Motsinger-Reif, Alison

AU - Koppelman, Gerard H

AU - Bustamante, Mariona

AU - Levy, Daniel

AU - London, Stephanie J

PY - 2019/10

Y1 - 2019/10

N2 - Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.

AB - Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.

U2 - 10.2217/epi-2019-0066

DO - 10.2217/epi-2019-0066

M3 - Article

C2 - 31536415

VL - 11

SP - 1487

EP - 1500

JO - Epigenomics

JF - Epigenomics

SN - 1750-1911

IS - 13

ER -

ID: 97976562