Comorbidity in childhood asthma

de Groot, E. P., 2016, [Groningen]: Rijksuniversiteit Groningen. 155 p.

Research output: ThesisThesis fully internal (DIV)Academic

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  • Eric Peter de Groot
This thesis focuses on comorbid conditions and its impact on asthma in children.
Comorbidities in children with asthma are allergic rhinitis(AR), dysfunctional breathing(DB) and depressive disorders. The prevalence of AR in children with asthma is 76.2%. AR was diagnosed in only 56.1%. Uncontrolled asthma was more common in children with AR. The negative impact on asthma control disappeared in those treated with intranasal corticosteroids. DB in children with asthma using the Nijmegen questionnaire was identified in 5.3%. Asthma control was worse in children with DB. No significant differences were found on anxiety, depression or self-esteem between children with or without asthma. The risk of anxiety and depression increased with decreasing asthma control. An underlying cause of uncontrolled asthma could be identified in 97.2%. The causes were: poor adherence(37%), ongoing exposure to environmental triggers(28%), comorbidities(20%), AR and DB being the most common. Incorrect inhalation technique(8%). Six (4.2%) had an another diagnosis than asthma. The prevalence of true therapy resistant asthma was 2.8%. True therapy resistant asthma is very rare, in the majority of cases addressing the basics of asthma management led to well-controlled asthma. The overall conclusions are that true therapy resistant asthma is rare. Comorbidities are an important part of these causes. AR is frequently unrecognised but it is important and treatable. DB is less common, but it has an impact on asthma control. In well controlled asthma psychological comorbidities are rare, but less well controlled asthma seems to be associated with an increased risk of psychological comorbidities.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Duiverman, E.J. (Eric), Supervisor, External person
  • Brand, Paulus, Supervisor
  • de Jongste, J. C., Assessment committee, External person
  • Dompeling, E., Assessment committee, External person
  • Berger, Y.M., Assessment committee, External person
Award date13-Jun-2016
Place of Publication[Groningen]
Print ISBNs978-94-6169-883-4
Publication statusPublished - 2016

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