Publication

Common brain disorders are associated with heritable patterns of apparent aging of the brain

Karolinska Schizophrenia Project (KaSP), Kaufmann, T., van der Meer, D., Doan, N. T., Schwarz, E., Lund, M. J., Agartz, I., Alnæs, D., Barch, D. M., Baur-Streubel, R., Bertolino, A., Bettella, F., Beyer, M. K., Bøen, E., Borgwardt, S., Brandt, C. L., Buitelaar, J., Celius, E. G., Cervenka, S., Conzelmann, A., Córdova-Palomera, A., Dale, A. M., de Quervain, D. J. F., Carlo, P., Djurovic, S., Dørum, E. S., Eisenacher, S., Elvsåshagen, T., Espeseth, T., Fatouros-Bergman, H., Flyckt, L., Franke, B., Frei, O., Haatveit, B., Håberg, A. K., Harbo, H. F., Hartman, C. A., Heslenfeld, D., Hoekstra, P. J., Høgestøl, E. A., Jernigan, T. L., Jonassen, R., Jönsson, E. G., Kirsch, P., Kłoszewska, I., Kolskår, K. K., Landrø, N. I., Hellard, S., Lesch, K-P., Lovestone, S. & Wang, L., Oct-2019, In : Nature neuroscience. 22, 10, p. 1617-1623 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Karolinska Schizophrenia Project (KaSP), Kaufmann, T., van der Meer, D., Doan, N. T., Schwarz, E., Lund, M. J., Agartz, I., Alnæs, D., Barch, D. M., Baur-Streubel, R., Bertolino, A., Bettella, F., Beyer, M. K., Bøen, E., Borgwardt, S., Brandt, C. L., Buitelaar, J., Celius, E. G., Cervenka, S., ... Wang, L. (2019). Common brain disorders are associated with heritable patterns of apparent aging of the brain. Nature neuroscience, 22(10), 1617-1623. https://doi.org/10.1038/s41593-019-0471-7

Author

Karolinska Schizophrenia Project (KaSP) ; Kaufmann, Tobias ; van der Meer, Dennis ; Doan, Nhat Trung ; Schwarz, Emanuel ; Lund, Martina J ; Agartz, Ingrid ; Alnæs, Dag ; Barch, Deanna M ; Baur-Streubel, Ramona ; Bertolino, Alessandro ; Bettella, Francesco ; Beyer, Mona K ; Bøen, Erlend ; Borgwardt, Stefan ; Brandt, Christine L ; Buitelaar, Jan ; Celius, Elisabeth G ; Cervenka, Simon ; Conzelmann, Annette ; Córdova-Palomera, Aldo ; Dale, Anders M ; de Quervain, Dominique J F ; Carlo, PasqualeDi ; Djurovic, Srdjan ; Dørum, Erlend S ; Eisenacher, Sarah ; Elvsåshagen, Torbjørn ; Espeseth, Thomas ; Fatouros-Bergman, Helena ; Flyckt, Lena ; Franke, Barbara ; Frei, Oleksandr ; Haatveit, Beathe ; Håberg, Asta K ; Harbo, Hanne F ; Hartman, Catharina A ; Heslenfeld, Dirk ; Hoekstra, Pieter J ; Høgestøl, Einar A ; Jernigan, Terry L ; Jonassen, Rune ; Jönsson, Erik G ; Kirsch, Peter ; Kłoszewska, Iwona ; Kolskår, Knut K ; Landrø, Nils Inge ; Hellard, StephanieLe ; Lesch, Klaus-Peter ; Lovestone, Simon ; Wang, Lei. / Common brain disorders are associated with heritable patterns of apparent aging of the brain. In: Nature neuroscience. 2019 ; Vol. 22, No. 10. pp. 1617-1623.

Harvard

Karolinska Schizophrenia Project (KaSP), Kaufmann, T, van der Meer, D, Doan, NT, Schwarz, E, Lund, MJ, Agartz, I, Alnæs, D, Barch, DM, Baur-Streubel, R, Bertolino, A, Bettella, F, Beyer, MK, Bøen, E, Borgwardt, S, Brandt, CL, Buitelaar, J, Celius, EG, Cervenka, S, Conzelmann, A, Córdova-Palomera, A, Dale, AM, de Quervain, DJF, Carlo, P, Djurovic, S, Dørum, ES, Eisenacher, S, Elvsåshagen, T, Espeseth, T, Fatouros-Bergman, H, Flyckt, L, Franke, B, Frei, O, Haatveit, B, Håberg, AK, Harbo, HF, Hartman, CA, Heslenfeld, D, Hoekstra, PJ, Høgestøl, EA, Jernigan, TL, Jonassen, R, Jönsson, EG, Kirsch, P, Kłoszewska, I, Kolskår, KK, Landrø, NI, Hellard, S, Lesch, K-P, Lovestone, S & Wang, L 2019, 'Common brain disorders are associated with heritable patterns of apparent aging of the brain', Nature neuroscience, vol. 22, no. 10, pp. 1617-1623. https://doi.org/10.1038/s41593-019-0471-7

Standard

Common brain disorders are associated with heritable patterns of apparent aging of the brain. / Karolinska Schizophrenia Project (KaSP); Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina J; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M; Baur-Streubel, Ramona; Bertolino, Alessandro; Bettella, Francesco; Beyer, Mona K; Bøen, Erlend; Borgwardt, Stefan; Brandt, Christine L; Buitelaar, Jan; Celius, Elisabeth G; Cervenka, Simon; Conzelmann, Annette; Córdova-Palomera, Aldo; Dale, Anders M; de Quervain, Dominique J F; Carlo, PasqualeDi; Djurovic, Srdjan; Dørum, Erlend S; Eisenacher, Sarah; Elvsåshagen, Torbjørn; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Haatveit, Beathe; Håberg, Asta K; Harbo, Hanne F; Hartman, Catharina A; Heslenfeld, Dirk; Hoekstra, Pieter J; Høgestøl, Einar A; Jernigan, Terry L; Jonassen, Rune; Jönsson, Erik G; Kirsch, Peter; Kłoszewska, Iwona; Kolskår, Knut K; Landrø, Nils Inge; Hellard, StephanieLe; Lesch, Klaus-Peter; Lovestone, Simon; Wang, Lei.

In: Nature neuroscience, Vol. 22, No. 10, 10.2019, p. 1617-1623.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Karolinska Schizophrenia Project (KaSP), Kaufmann T, van der Meer D, Doan NT, Schwarz E, Lund MJ et al. Common brain disorders are associated with heritable patterns of apparent aging of the brain. Nature neuroscience. 2019 Oct;22(10):1617-1623. https://doi.org/10.1038/s41593-019-0471-7


BibTeX

@article{3b5c63b82d3a4839b60de2ac0caa5be9,
title = "Common brain disorders are associated with heritable patterns of apparent aging of the brain",
abstract = "Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Aging/genetics, Algorithms, Brain/diagnostic imaging, Brain Diseases/diagnostic imaging, Child, Child, Preschool, Female, Genome-Wide Association Study, Humans, Infant, Magnetic Resonance Imaging, Male, Mental Disorders/diagnostic imaging, Middle Aged, Neuropsychological Tests, Schizophrenia/genetics, Sex Characteristics, Young Adult",
author = "{Karolinska Schizophrenia Project (KaSP)} and Tobias Kaufmann and {van der Meer}, Dennis and Doan, {Nhat Trung} and Emanuel Schwarz and Lund, {Martina J} and Ingrid Agartz and Dag Aln{\ae}s and Barch, {Deanna M} and Ramona Baur-Streubel and Alessandro Bertolino and Francesco Bettella and Beyer, {Mona K} and Erlend B{\o}en and Stefan Borgwardt and Brandt, {Christine L} and Jan Buitelaar and Celius, {Elisabeth G} and Simon Cervenka and Annette Conzelmann and Aldo C{\'o}rdova-Palomera and Dale, {Anders M} and {de Quervain}, {Dominique J F} and PasqualeDi Carlo and Srdjan Djurovic and D{\o}rum, {Erlend S} and Sarah Eisenacher and Torbj{\o}rn Elvs{\aa}shagen and Thomas Espeseth and Helena Fatouros-Bergman and Lena Flyckt and Barbara Franke and Oleksandr Frei and Beathe Haatveit and H{\aa}berg, {Asta K} and Harbo, {Hanne F} and Hartman, {Catharina A} and Dirk Heslenfeld and Hoekstra, {Pieter J} and H{\o}gest{\o}l, {Einar A} and Jernigan, {Terry L} and Rune Jonassen and J{\"o}nsson, {Erik G} and Peter Kirsch and Iwona K{\l}oszewska and Kolsk{\aa}r, {Knut K} and Landr{\o}, {Nils Inge} and StephanieLe Hellard and Klaus-Peter Lesch and Simon Lovestone and Lei Wang",
year = "2019",
month = oct,
doi = "10.1038/s41593-019-0471-7",
language = "English",
volume = "22",
pages = "1617--1623",
journal = "Nature neuroscience",
issn = "1097-6256",
publisher = "NATURE AMERICA INC",
number = "10",

}

RIS

TY - JOUR

T1 - Common brain disorders are associated with heritable patterns of apparent aging of the brain

AU - Karolinska Schizophrenia Project (KaSP)

AU - Kaufmann, Tobias

AU - van der Meer, Dennis

AU - Doan, Nhat Trung

AU - Schwarz, Emanuel

AU - Lund, Martina J

AU - Agartz, Ingrid

AU - Alnæs, Dag

AU - Barch, Deanna M

AU - Baur-Streubel, Ramona

AU - Bertolino, Alessandro

AU - Bettella, Francesco

AU - Beyer, Mona K

AU - Bøen, Erlend

AU - Borgwardt, Stefan

AU - Brandt, Christine L

AU - Buitelaar, Jan

AU - Celius, Elisabeth G

AU - Cervenka, Simon

AU - Conzelmann, Annette

AU - Córdova-Palomera, Aldo

AU - Dale, Anders M

AU - de Quervain, Dominique J F

AU - Carlo, PasqualeDi

AU - Djurovic, Srdjan

AU - Dørum, Erlend S

AU - Eisenacher, Sarah

AU - Elvsåshagen, Torbjørn

AU - Espeseth, Thomas

AU - Fatouros-Bergman, Helena

AU - Flyckt, Lena

AU - Franke, Barbara

AU - Frei, Oleksandr

AU - Haatveit, Beathe

AU - Håberg, Asta K

AU - Harbo, Hanne F

AU - Hartman, Catharina A

AU - Heslenfeld, Dirk

AU - Hoekstra, Pieter J

AU - Høgestøl, Einar A

AU - Jernigan, Terry L

AU - Jonassen, Rune

AU - Jönsson, Erik G

AU - Kirsch, Peter

AU - Kłoszewska, Iwona

AU - Kolskår, Knut K

AU - Landrø, Nils Inge

AU - Hellard, StephanieLe

AU - Lesch, Klaus-Peter

AU - Lovestone, Simon

AU - Wang, Lei

PY - 2019/10

Y1 - 2019/10

N2 - Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

AB - Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Aging/genetics

KW - Algorithms

KW - Brain/diagnostic imaging

KW - Brain Diseases/diagnostic imaging

KW - Child

KW - Child, Preschool

KW - Female

KW - Genome-Wide Association Study

KW - Humans

KW - Infant

KW - Magnetic Resonance Imaging

KW - Male

KW - Mental Disorders/diagnostic imaging

KW - Middle Aged

KW - Neuropsychological Tests

KW - Schizophrenia/genetics

KW - Sex Characteristics

KW - Young Adult

U2 - 10.1038/s41593-019-0471-7

DO - 10.1038/s41593-019-0471-7

M3 - Article

C2 - 31551603

VL - 22

SP - 1617

EP - 1623

JO - Nature neuroscience

JF - Nature neuroscience

SN - 1097-6256

IS - 10

ER -

ID: 102155398