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Common brain disorders are associated with heritable patterns of apparent aging of the brain

Karolinska Schizophrenia Project (KaSP), Kaufmann, T., van der Meer, D., Doan, N. T., Schwarz, E., Lund, M. J., Agartz, I., Alnæs, D., Barch, D. M., Baur-Streubel, R., Bertolino, A., Bettella, F., Beyer, M. K., Bøen, E., Borgwardt, S., Brandt, C. L., Buitelaar, J., Celius, E. G., Cervenka, S., Conzelmann, A., Córdova-Palomera, A., Dale, A. M., de Quervain, D. J. F., Carlo, P., Djurovic, S., Dørum, E. S., Eisenacher, S., Elvsåshagen, T., Espeseth, T., Fatouros-Bergman, H., Flyckt, L., Franke, B., Frei, O., Haatveit, B., Håberg, A. K., Harbo, H. F., Hartman, C. A., Heslenfeld, D., Hoekstra, P. J., Høgestøl, E. A., Jernigan, T. L., Jonassen, R., Jönsson, E. G., Kirsch, P., Kłoszewska, I., Kolskår, K. K., Landrø, N. I., Hellard, S., Lesch, K-P., Lovestone, S. & Wang, L., Oct-2019, In : Nature neuroscience. 22, 10, p. 1617-1623 7 p.

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  • Common brain disorders are associated with heritable patterns of apparent aging of the brain

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DOI

  • Karolinska Schizophrenia Project (KaSP)
  • Tobias Kaufmann
  • Dennis van der Meer
  • Nhat Trung Doan
  • Emanuel Schwarz
  • Martina J Lund
  • Ingrid Agartz
  • Dag Alnæs
  • Deanna M Barch
  • Ramona Baur-Streubel
  • Alessandro Bertolino
  • Francesco Bettella
  • Mona K Beyer
  • Erlend Bøen
  • Stefan Borgwardt
  • Christine L Brandt
  • Jan Buitelaar
  • Elisabeth G Celius
  • Simon Cervenka
  • Annette Conzelmann
  • Aldo Córdova-Palomera
  • Anders M Dale
  • Dominique J F de Quervain
  • PasqualeDi Carlo
  • Srdjan Djurovic
  • Erlend S Dørum
  • Sarah Eisenacher
  • Torbjørn Elvsåshagen
  • Thomas Espeseth
  • Helena Fatouros-Bergman
  • Lena Flyckt
  • Barbara Franke
  • Oleksandr Frei
  • Beathe Haatveit
  • Asta K Håberg
  • Hanne F Harbo
  • Catharina A Hartman
  • Dirk Heslenfeld
  • Pieter J Hoekstra
  • Einar A Høgestøl
  • Terry L Jernigan
  • Rune Jonassen
  • Erik G Jönsson
  • Peter Kirsch
  • Iwona Kłoszewska
  • Knut K Kolskår
  • Nils Inge Landrø
  • StephanieLe Hellard
  • Klaus-Peter Lesch
  • Simon Lovestone
  • Lei Wang

Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

Original languageEnglish
Pages (from-to)1617-1623
Number of pages7
JournalNature neuroscience
Volume22
Issue number10
Publication statusPublished - Oct-2019

    Keywords

  • Adolescent, Adult, Aged, Aged, 80 and over, Aging/genetics, Algorithms, Brain/diagnostic imaging, Brain Diseases/diagnostic imaging, Child, Child, Preschool, Female, Genome-Wide Association Study, Humans, Infant, Magnetic Resonance Imaging, Male, Mental Disorders/diagnostic imaging, Middle Aged, Neuropsychological Tests, Schizophrenia/genetics, Sex Characteristics, Young Adult

ID: 102155398