Combinatorial screening for specific drug solubilizers with switchable release profilesWieczorek, S., Vigne, S., Masini, T., Ponader, D., Hartmann, L., Hirsch, A. K. H. & Börner, H. G., Jan-2015, In : Macromolecular Bioscience. 15, 1, p. 82-89 8 p.
Research output: Contribution to journal › Article › Academic › peer-review
Polymer-block-peptide conjugates are tailored to render hydrophobic small molecule drugs water soluble. The combinatorial strategy selects for bioconjugates that exhibit sequence-specific solubilization and switchable release profiles of the cargo through incorporation of a disulfide linker moiety into the peptide-library design. While the study focused on the photosensitizer m-THPC and reductive carrier cleavage, the approach is generic and might be expanded toward a broad range of poorly soluble small-molecule drugs and other selective cleavage mechanisms to disassemble a peptide binding domain of the bioconjugate-based solubilizer.
|Number of pages||8|
|Publication status||Published - Jan-2015|