Publication

Collateral Circulation and Outcome in Atherosclerotic Versus Cardioembolic Cerebral Large Vessel Occlusion

MR CLEAN Registry Investigators, Guglielmi, V., LeCouffe, N. E., Zinkstok, S. M., Compagne, K. C. J., Eker, R., Treurniet, K. M., Tolhuisen, M. L., van der Worp, H. B., Jansen, I. G. H., van Oostenbrugge, R. J., Marquering, H. A., Dippel, D. W. J., Emmer, B. J., Majoie, C. B. L. M., Roos, Y. B. W. E. M. & Coutinho, J. M., Dec-2019, In : Stroke. 50, 12, p. 3360-3368 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

MR CLEAN Registry Investigators, Guglielmi, V., LeCouffe, N. E., Zinkstok, S. M., Compagne, K. C. J., Eker, R., ... Coutinho, J. M. (2019). Collateral Circulation and Outcome in Atherosclerotic Versus Cardioembolic Cerebral Large Vessel Occlusion. Stroke, 50(12), 3360-3368. https://doi.org/10.1161/STROKEAHA.119.026299

Author

MR CLEAN Registry Investigators ; Guglielmi, Valeria ; LeCouffe, Natalie E. ; Zinkstok, Sanne M. ; Compagne, Kars C. J. ; Eker, Reyhan ; Treurniet, Kilian M. ; Tolhuisen, Manon L. ; van der Worp, H. Bart ; Jansen, Ivo G. H. ; van Oostenbrugge, Robert J. ; Marquering, Henk A. ; Dippel, Diederik W. J. ; Emmer, Bart J. ; Majoie, Charles B. L. M. ; Roos, Yvo B. W. E. M. ; Coutinho, Jonathan M. / Collateral Circulation and Outcome in Atherosclerotic Versus Cardioembolic Cerebral Large Vessel Occlusion. In: Stroke. 2019 ; Vol. 50, No. 12. pp. 3360-3368.

Harvard

MR CLEAN Registry Investigators, Guglielmi, V, LeCouffe, NE, Zinkstok, SM, Compagne, KCJ, Eker, R, Treurniet, KM, Tolhuisen, ML, van der Worp, HB, Jansen, IGH, van Oostenbrugge, RJ, Marquering, HA, Dippel, DWJ, Emmer, BJ, Majoie, CBLM, Roos, YBWEM & Coutinho, JM 2019, 'Collateral Circulation and Outcome in Atherosclerotic Versus Cardioembolic Cerebral Large Vessel Occlusion', Stroke, vol. 50, no. 12, pp. 3360-3368. https://doi.org/10.1161/STROKEAHA.119.026299

Standard

Collateral Circulation and Outcome in Atherosclerotic Versus Cardioembolic Cerebral Large Vessel Occlusion. / MR CLEAN Registry Investigators; Guglielmi, Valeria; LeCouffe, Natalie E.; Zinkstok, Sanne M.; Compagne, Kars C. J.; Eker, Reyhan; Treurniet, Kilian M.; Tolhuisen, Manon L.; van der Worp, H. Bart; Jansen, Ivo G. H.; van Oostenbrugge, Robert J.; Marquering, Henk A.; Dippel, Diederik W. J.; Emmer, Bart J.; Majoie, Charles B. L. M.; Roos, Yvo B. W. E. M.; Coutinho, Jonathan M.

In: Stroke, Vol. 50, No. 12, 12.2019, p. 3360-3368.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

MR CLEAN Registry Investigators, Guglielmi V, LeCouffe NE, Zinkstok SM, Compagne KCJ, Eker R et al. Collateral Circulation and Outcome in Atherosclerotic Versus Cardioembolic Cerebral Large Vessel Occlusion. Stroke. 2019 Dec;50(12):3360-3368. https://doi.org/10.1161/STROKEAHA.119.026299


BibTeX

@article{d649fafd9ddc43b495e116fc7e1b0a50,
title = "Collateral Circulation and Outcome in Atherosclerotic Versus Cardioembolic Cerebral Large Vessel Occlusion",
abstract = "Background and Purpose-Due to chronic hypoperfusion, cervical atherosclerosis may promote cerebral collateral circulation. We hypothesized that patients with ischemic stroke due to cervical carotid atherosclerosis have a more extensive collateral circulation and better outcomes than patients with cardioembolism. We tested this hypothesis in a population of patients who underwent endovascular treatment for large vessel occlusion.Methods-From the MR-CLEAN Registry (Multicenter Randomized Controlled Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands), we selected consecutive adult endovascular treatment patients (March 2014 to June 2016) with acute ischemic stroke due to anterior circulation large vessel occlusion and compared patients with cervical carotid artery stenosis >50{\%} to those with cardioembolic etiology. The primary outcome was collateral score, graded on a 4-point scale. Secondary outcomes included the modified Rankin Scale (mRS) score and mortality at 90 days. We performed multivariable regression analyses and adjusted for potential confounders.Results-Of 1627 patients in the Registry, 190 patients with cervical carotid atherosclerosis and 476 with cardioembolism were included. Patients with cervical carotid atherosclerosis were younger (median 69 versus 76 years, PConclusions-Patients with stroke due to cervical carotid atherosclerosis had a more extensive cerebral collateral circulation and a slightly better median mRS at 90 days than patients with cardioembolic stroke.",
keywords = "atherothrombotic stroke, cardiac emboli, collateral circulation, endovascular treatment, ischemic stroke, ACUTE ISCHEMIC-STROKE, ATRIAL-FIBRILLATION, CT ANGIOGRAPHY, UNDETERMINED SOURCE, EMBOLIC STROKES, FEATURES, CLASSIFICATION, HYPOPERFUSION, THROMBECTOMY, ETIOLOGY",
author = "{MR CLEAN Registry Investigators} and Valeria Guglielmi and LeCouffe, {Natalie E.} and Zinkstok, {Sanne M.} and Compagne, {Kars C. J.} and Reyhan Eker and Treurniet, {Kilian M.} and Tolhuisen, {Manon L.} and {van der Worp}, {H. Bart} and Jansen, {Ivo G. H.} and {van Oostenbrugge}, {Robert J.} and Marquering, {Henk A.} and Dippel, {Diederik W. J.} and Emmer, {Bart J.} and Majoie, {Charles B. L. M.} and Roos, {Yvo B. W. E. M.} and Coutinho, {Jonathan M.} and {van der Lugt}, Aad and {van Zwam}, {Wim H.} and Jelis Boiten and Vos, {Jan A.} and Mulder, {Maxim J. H. L.} and Goldhoorn, {Robert-Jan B.} and Manon Kappelhof and Schonewille, {Wouter J.} and Wermer, {Marieke J. H.} and {van Walderveen}, {Marianne A. A.} and Julie Staals and Jeannette Hofmeijer and Martens, {Jasper M.} and Nijeholt, {Geert J. Lycklama A.} and Bob Roozenbeek and {de Bruijn}, {Sebastiaan F.} and {van Dijk}, {Lukas C.} and Lo, {Rob H.} and {van Dijk}, {Ewoud J.} and Boogaarts, {Hieronymus D.} and {de Kort}, {Paul L. M.} and Peluso, {Jo P.} and {van den Berg}, {Jan S. P.} and {van Hasselt}, {Boudewijn A. A. M.} and Aerden, {Leo A. M.} and Dallinga, {Rene J.} and Maarten Uyttenboogaart and Omid Eshghi and Schreuder, {Tobien H. C. M. L.} and Heijboer, {Roel J. J.} and Koos Keizer and Yo, {Lonneke S. F.} and Boers, {Anna M. M.} and Groot, {P. F. C.}",
year = "2019",
month = "12",
doi = "10.1161/STROKEAHA.119.026299",
language = "English",
volume = "50",
pages = "3360--3368",
journal = "Stroke",
issn = "0039-2499",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "12",

}

RIS

TY - JOUR

T1 - Collateral Circulation and Outcome in Atherosclerotic Versus Cardioembolic Cerebral Large Vessel Occlusion

AU - MR CLEAN Registry Investigators

AU - Guglielmi, Valeria

AU - LeCouffe, Natalie E.

AU - Zinkstok, Sanne M.

AU - Compagne, Kars C. J.

AU - Eker, Reyhan

AU - Treurniet, Kilian M.

AU - Tolhuisen, Manon L.

AU - van der Worp, H. Bart

AU - Jansen, Ivo G. H.

AU - van Oostenbrugge, Robert J.

AU - Marquering, Henk A.

AU - Dippel, Diederik W. J.

AU - Emmer, Bart J.

AU - Majoie, Charles B. L. M.

AU - Roos, Yvo B. W. E. M.

AU - Coutinho, Jonathan M.

AU - van der Lugt, Aad

AU - van Zwam, Wim H.

AU - Boiten, Jelis

AU - Vos, Jan A.

AU - Mulder, Maxim J. H. L.

AU - Goldhoorn, Robert-Jan B.

AU - Kappelhof, Manon

AU - Schonewille, Wouter J.

AU - Wermer, Marieke J. H.

AU - van Walderveen, Marianne A. A.

AU - Staals, Julie

AU - Hofmeijer, Jeannette

AU - Martens, Jasper M.

AU - Nijeholt, Geert J. Lycklama A.

AU - Roozenbeek, Bob

AU - de Bruijn, Sebastiaan F.

AU - van Dijk, Lukas C.

AU - Lo, Rob H.

AU - van Dijk, Ewoud J.

AU - Boogaarts, Hieronymus D.

AU - de Kort, Paul L. M.

AU - Peluso, Jo P.

AU - van den Berg, Jan S. P.

AU - van Hasselt, Boudewijn A. A. M.

AU - Aerden, Leo A. M.

AU - Dallinga, Rene J.

AU - Uyttenboogaart, Maarten

AU - Eshghi, Omid

AU - Schreuder, Tobien H. C. M. L.

AU - Heijboer, Roel J. J.

AU - Keizer, Koos

AU - Yo, Lonneke S. F.

AU - Boers, Anna M. M.

AU - Groot, P. F. C.

PY - 2019/12

Y1 - 2019/12

N2 - Background and Purpose-Due to chronic hypoperfusion, cervical atherosclerosis may promote cerebral collateral circulation. We hypothesized that patients with ischemic stroke due to cervical carotid atherosclerosis have a more extensive collateral circulation and better outcomes than patients with cardioembolism. We tested this hypothesis in a population of patients who underwent endovascular treatment for large vessel occlusion.Methods-From the MR-CLEAN Registry (Multicenter Randomized Controlled Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands), we selected consecutive adult endovascular treatment patients (March 2014 to June 2016) with acute ischemic stroke due to anterior circulation large vessel occlusion and compared patients with cervical carotid artery stenosis >50% to those with cardioembolic etiology. The primary outcome was collateral score, graded on a 4-point scale. Secondary outcomes included the modified Rankin Scale (mRS) score and mortality at 90 days. We performed multivariable regression analyses and adjusted for potential confounders.Results-Of 1627 patients in the Registry, 190 patients with cervical carotid atherosclerosis and 476 with cardioembolism were included. Patients with cervical carotid atherosclerosis were younger (median 69 versus 76 years, PConclusions-Patients with stroke due to cervical carotid atherosclerosis had a more extensive cerebral collateral circulation and a slightly better median mRS at 90 days than patients with cardioembolic stroke.

AB - Background and Purpose-Due to chronic hypoperfusion, cervical atherosclerosis may promote cerebral collateral circulation. We hypothesized that patients with ischemic stroke due to cervical carotid atherosclerosis have a more extensive collateral circulation and better outcomes than patients with cardioembolism. We tested this hypothesis in a population of patients who underwent endovascular treatment for large vessel occlusion.Methods-From the MR-CLEAN Registry (Multicenter Randomized Controlled Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands), we selected consecutive adult endovascular treatment patients (March 2014 to June 2016) with acute ischemic stroke due to anterior circulation large vessel occlusion and compared patients with cervical carotid artery stenosis >50% to those with cardioembolic etiology. The primary outcome was collateral score, graded on a 4-point scale. Secondary outcomes included the modified Rankin Scale (mRS) score and mortality at 90 days. We performed multivariable regression analyses and adjusted for potential confounders.Results-Of 1627 patients in the Registry, 190 patients with cervical carotid atherosclerosis and 476 with cardioembolism were included. Patients with cervical carotid atherosclerosis were younger (median 69 versus 76 years, PConclusions-Patients with stroke due to cervical carotid atherosclerosis had a more extensive cerebral collateral circulation and a slightly better median mRS at 90 days than patients with cardioembolic stroke.

KW - atherothrombotic stroke

KW - cardiac emboli

KW - collateral circulation

KW - endovascular treatment

KW - ischemic stroke

KW - ACUTE ISCHEMIC-STROKE

KW - ATRIAL-FIBRILLATION

KW - CT ANGIOGRAPHY

KW - UNDETERMINED SOURCE

KW - EMBOLIC STROKES

KW - FEATURES

KW - CLASSIFICATION

KW - HYPOPERFUSION

KW - THROMBECTOMY

KW - ETIOLOGY

U2 - 10.1161/STROKEAHA.119.026299

DO - 10.1161/STROKEAHA.119.026299

M3 - Article

VL - 50

SP - 3360

EP - 3368

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 12

ER -

ID: 117209143