Publication

Cognitive performance in depressed older persons: the impact of vascular burden and remission. A two-year follow-up study

Zuidersma, M., Comijs, H. C., Naarding, P. & Oude Voshaar, R. C., Sep-2016, In : International Journal of Geriatric Psychiatry. 31, 9, p. 1029-1039 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Zuidersma, M., Comijs, H. C., Naarding, P., & Oude Voshaar, R. C. (2016). Cognitive performance in depressed older persons: the impact of vascular burden and remission. A two-year follow-up study. International Journal of Geriatric Psychiatry, 31(9), 1029-1039. https://doi.org/10.1002/gps.4416

Author

Zuidersma, Marij ; Comijs, Hannie C. ; Naarding, Paul ; Oude Voshaar, Richard C. . / Cognitive performance in depressed older persons : the impact of vascular burden and remission. A two-year follow-up study. In: International Journal of Geriatric Psychiatry. 2016 ; Vol. 31, No. 9. pp. 1029-1039.

Harvard

Zuidersma, M, Comijs, HC, Naarding, P & Oude Voshaar, RC 2016, 'Cognitive performance in depressed older persons: the impact of vascular burden and remission. A two-year follow-up study', International Journal of Geriatric Psychiatry, vol. 31, no. 9, pp. 1029-1039. https://doi.org/10.1002/gps.4416

Standard

Cognitive performance in depressed older persons : the impact of vascular burden and remission. A two-year follow-up study. / Zuidersma, Marij; Comijs, Hannie C.; Naarding, Paul; Oude Voshaar, Richard C. .

In: International Journal of Geriatric Psychiatry, Vol. 31, No. 9, 09.2016, p. 1029-1039.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Zuidersma M, Comijs HC, Naarding P, Oude Voshaar RC. Cognitive performance in depressed older persons: the impact of vascular burden and remission. A two-year follow-up study. International Journal of Geriatric Psychiatry. 2016 Sep;31(9):1029-1039. https://doi.org/10.1002/gps.4416


BibTeX

@article{cb364e9680f54633b6d99daaa365de3b,
title = "Cognitive performance in depressed older persons: the impact of vascular burden and remission. A two-year follow-up study",
abstract = "Objectives: Depression is associated with an increased risk of cognitive decline. The present study compared two-year change in cognitive performance between depressed older persons and a non-depressed control group, between remitted and non-remitted patients, and evaluated whether vascular burden at baseline was associated with more cognitive decline in depressed older persons.Methods: Depressed patients (n = 378) aged >= 60 were recruited from mental healthcare institutes and general practices, and a non-depressed control group (n = 132) was recruited from general practices. A DSM-IV depressive episode was established with the Composite International Diagnostic Interview, and processing speed, working memory, verbal memory and interference control were evaluated with three neurocognitive tasks at baseline and 2 years later. A modified Framingham Risk Score, anklebrachial index, and history of a vascular event defined vascular burden at baseline.Results: After adjusting for baseline cognitive performance, age, sex, and education level, depressed older persons had worse processing speed and verbal memory scores at follow-up than controls (regression coefficients: -0.172; p = 0.042 and -0.309; p = 0.001, respectively) but did not differ in the other two-cognitive outcomes. In the sample of depressed patients, remission status at 2 years follow-up and baseline vascular burden did not predict cognitive performance at follow-up, after adjustment for baseline cognitive performance, age, sex and education level.Conclusions: Our findings suggest that cognitive deficits in depressed older persons are not just a manifestation of depression. In addition, vascular burden was not associated with worse cognitive decline in a sample of depressed older persons. Copyright (C) 2016 John Wiley & Sons, Ltd.",
keywords = "processing speed, working memory, verbal memory, interference control, depression remission, vascular risk, LATE-LIFE DEPRESSION, WHITE-MATTER HYPERINTENSITIES, CEREBROVASCULAR RISK-FACTORS, NURSING-HOME ADMISSION, MAJOR DEPRESSION, HIPPOCAMPAL VOLUME, ALZHEIMER-DISEASE, EXCESS MORTALITY, CORTISOL-LEVELS, IMPAIRMENT",
author = "Marij Zuidersma and Comijs, {Hannie C.} and Paul Naarding and {Oude Voshaar}, {Richard C.}",
year = "2016",
month = sep,
doi = "10.1002/gps.4416",
language = "English",
volume = "31",
pages = "1029--1039",
journal = "International Journal of Geriatric Psychiatry",
issn = "0885-6230",
publisher = "Wiley",
number = "9",

}

RIS

TY - JOUR

T1 - Cognitive performance in depressed older persons

T2 - the impact of vascular burden and remission. A two-year follow-up study

AU - Zuidersma, Marij

AU - Comijs, Hannie C.

AU - Naarding, Paul

AU - Oude Voshaar, Richard C.

PY - 2016/9

Y1 - 2016/9

N2 - Objectives: Depression is associated with an increased risk of cognitive decline. The present study compared two-year change in cognitive performance between depressed older persons and a non-depressed control group, between remitted and non-remitted patients, and evaluated whether vascular burden at baseline was associated with more cognitive decline in depressed older persons.Methods: Depressed patients (n = 378) aged >= 60 were recruited from mental healthcare institutes and general practices, and a non-depressed control group (n = 132) was recruited from general practices. A DSM-IV depressive episode was established with the Composite International Diagnostic Interview, and processing speed, working memory, verbal memory and interference control were evaluated with three neurocognitive tasks at baseline and 2 years later. A modified Framingham Risk Score, anklebrachial index, and history of a vascular event defined vascular burden at baseline.Results: After adjusting for baseline cognitive performance, age, sex, and education level, depressed older persons had worse processing speed and verbal memory scores at follow-up than controls (regression coefficients: -0.172; p = 0.042 and -0.309; p = 0.001, respectively) but did not differ in the other two-cognitive outcomes. In the sample of depressed patients, remission status at 2 years follow-up and baseline vascular burden did not predict cognitive performance at follow-up, after adjustment for baseline cognitive performance, age, sex and education level.Conclusions: Our findings suggest that cognitive deficits in depressed older persons are not just a manifestation of depression. In addition, vascular burden was not associated with worse cognitive decline in a sample of depressed older persons. Copyright (C) 2016 John Wiley & Sons, Ltd.

AB - Objectives: Depression is associated with an increased risk of cognitive decline. The present study compared two-year change in cognitive performance between depressed older persons and a non-depressed control group, between remitted and non-remitted patients, and evaluated whether vascular burden at baseline was associated with more cognitive decline in depressed older persons.Methods: Depressed patients (n = 378) aged >= 60 were recruited from mental healthcare institutes and general practices, and a non-depressed control group (n = 132) was recruited from general practices. A DSM-IV depressive episode was established with the Composite International Diagnostic Interview, and processing speed, working memory, verbal memory and interference control were evaluated with three neurocognitive tasks at baseline and 2 years later. A modified Framingham Risk Score, anklebrachial index, and history of a vascular event defined vascular burden at baseline.Results: After adjusting for baseline cognitive performance, age, sex, and education level, depressed older persons had worse processing speed and verbal memory scores at follow-up than controls (regression coefficients: -0.172; p = 0.042 and -0.309; p = 0.001, respectively) but did not differ in the other two-cognitive outcomes. In the sample of depressed patients, remission status at 2 years follow-up and baseline vascular burden did not predict cognitive performance at follow-up, after adjustment for baseline cognitive performance, age, sex and education level.Conclusions: Our findings suggest that cognitive deficits in depressed older persons are not just a manifestation of depression. In addition, vascular burden was not associated with worse cognitive decline in a sample of depressed older persons. Copyright (C) 2016 John Wiley & Sons, Ltd.

KW - processing speed

KW - working memory

KW - verbal memory

KW - interference control

KW - depression remission

KW - vascular risk

KW - LATE-LIFE DEPRESSION

KW - WHITE-MATTER HYPERINTENSITIES

KW - CEREBROVASCULAR RISK-FACTORS

KW - NURSING-HOME ADMISSION

KW - MAJOR DEPRESSION

KW - HIPPOCAMPAL VOLUME

KW - ALZHEIMER-DISEASE

KW - EXCESS MORTALITY

KW - CORTISOL-LEVELS

KW - IMPAIRMENT

U2 - 10.1002/gps.4416

DO - 10.1002/gps.4416

M3 - Article

VL - 31

SP - 1029

EP - 1039

JO - International Journal of Geriatric Psychiatry

JF - International Journal of Geriatric Psychiatry

SN - 0885-6230

IS - 9

ER -

ID: 38521389