Publication

Coenzyme A: to make it or uptake it?

Sibon, O. C. M. & Strauss, E., Oct-2016, In : Nature Reviews Molecular Cell Biology. 17, 10, p. 605-606 2 p.

Research output: Contribution to journalEditorialAcademicpeer-review

The consensus has been that intracellular coenzyme A (CoA) is obtained exclusively by de novo biosynthesis via a universal, conserved five-step pathway in the cell cytosol. However, old and new evidence suggest that cells (and some microorganisms) have several strategies to obtain CoA, with 4'-phosphopantetheine (P-PantSH; the fourth intermediate in the canonical CoA biosynthetic pathway) serving as a 'nexus' metabolite.

Original languageEnglish
Pages (from-to)605-606
Number of pages2
JournalNature Reviews Molecular Cell Biology
Volume17
Issue number10
Publication statusPublished - Oct-2016

    Keywords

  • ESCHERICHIA-COLI, TRANSPORTER, 4-PHOSPHOPANTETHEINE, METABOLISM

ID: 39698670