Coenzyme A: to make it or uptake it?Sibon, O. C. M. & Strauss, E., Oct-2016, In : Nature Reviews Molecular Cell Biology. 17, 10, p. 605-606 2 p.
Research output: Contribution to journal › Editorial › Academic › peer-review
The consensus has been that intracellular coenzyme A (CoA) is obtained exclusively by de novo biosynthesis via a universal, conserved five-step pathway in the cell cytosol. However, old and new evidence suggest that cells (and some microorganisms) have several strategies to obtain CoA, with 4'-phosphopantetheine (P-PantSH; the fourth intermediate in the canonical CoA biosynthetic pathway) serving as a 'nexus' metabolite.
|Number of pages||2|
|Journal||Nature Reviews Molecular Cell Biology|
|Publication status||Published - Oct-2016|
- ESCHERICHIA-COLI, TRANSPORTER, 4-PHOSPHOPANTETHEINE, METABOLISM