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Clinical utility and research frontiers of neuroimaging in movement disorders
Nobili, F., Westman, E., Kogan, R. V., Pereira, J., Massa, F., Grazzini, M., Meles, S. & Leenders, K. L., Dec-2017, In : Quarterly Journal of Nuclear Medicine and Molecular Imaging. 61, 4, p. 372-385 14 p.Research output: Contribution to journal › Article › Academic › peer-review
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Clinical utility and research frontiers of neuroimaging in movement disorders. / Nobili, Flavio; Westman, Eric; Kogan, Rosalie Vered; Pereira, Joana; Massa, Federico; Grazzini, Matteo; Meles, Sanne; Leenders, Klaus L.
In: Quarterly Journal of Nuclear Medicine and Molecular Imaging, Vol. 61, No. 4, 12.2017, p. 372-385.Research output: Contribution to journal › Article › Academic › peer-review
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TY - JOUR
T1 - Clinical utility and research frontiers of neuroimaging in movement disorders
AU - Nobili, Flavio
AU - Westman, Eric
AU - Kogan, Rosalie Vered
AU - Pereira, Joana
AU - Massa, Federico
AU - Grazzini, Matteo
AU - Meles, Sanne
AU - Leenders, Klaus L.
PY - 2017/12
Y1 - 2017/12
N2 - Neuroimaging in Parkinson’s disease (PD) and other primary Parkinsonian disorders has been increasingly used in the routine clinical work in the last years. The paradigm has changed from an “exclusionary” use, i.e., to rule out causes of secondary Parkinsonism, to an “inclusionary” one, i.e., finding image and network characteristics allowing to identify a specific disease. This is allowed by analyses spanning from the commonly used visual analysis to the most sophisticated postprocessing leading to the identification of covariance patterns both in morphological and functional neuroimaging. However, paralleling the advancement in covariance and connectivity analyses, the issues of standardization and harmonization of data acquisition, and image reconstruction and postprocessing among centers are emerging in the scientific community. Also, the building of scientific evidence still suffers from the lack of large, formal studies and relies on relatively small cohort studies from one or few centers. Joint actions to face these issues are now ongoing in Europe, supported by specific programs, such as the Joint Programming on Neurodegenerative Diseases (JPND). In the present review, some of the most recent and relevant achievements in the field of diffusion tensor magnetic resonance imaging (MRI), functional MRI, fludeoxyglucose-positron-emission tomography, dopamine transporter single-photon emission computed tomography and non-dopaminergic imaging in PD and primary Parkinsonisms are reported.
AB - Neuroimaging in Parkinson’s disease (PD) and other primary Parkinsonian disorders has been increasingly used in the routine clinical work in the last years. The paradigm has changed from an “exclusionary” use, i.e., to rule out causes of secondary Parkinsonism, to an “inclusionary” one, i.e., finding image and network characteristics allowing to identify a specific disease. This is allowed by analyses spanning from the commonly used visual analysis to the most sophisticated postprocessing leading to the identification of covariance patterns both in morphological and functional neuroimaging. However, paralleling the advancement in covariance and connectivity analyses, the issues of standardization and harmonization of data acquisition, and image reconstruction and postprocessing among centers are emerging in the scientific community. Also, the building of scientific evidence still suffers from the lack of large, formal studies and relies on relatively small cohort studies from one or few centers. Joint actions to face these issues are now ongoing in Europe, supported by specific programs, such as the Joint Programming on Neurodegenerative Diseases (JPND). In the present review, some of the most recent and relevant achievements in the field of diffusion tensor magnetic resonance imaging (MRI), functional MRI, fludeoxyglucose-positron-emission tomography, dopamine transporter single-photon emission computed tomography and non-dopaminergic imaging in PD and primary Parkinsonisms are reported.
KW - Parkinson disease
KW - Parkinsonian disorders
KW - Magnetic resonance imaging
KW - Fluorodeoxyglucose F18
KW - Positron-emission tomography
KW - tomography, emission-computed, single-photon
U2 - 10.23736/S1824-4785.17.03018-7
DO - 10.23736/S1824-4785.17.03018-7
M3 - Article
VL - 61
SP - 372
EP - 385
JO - Quarterly Journal of Nuclear Medicine and Molecular Imaging
JF - Quarterly Journal of Nuclear Medicine and Molecular Imaging
SN - 1824-4661
IS - 4
ER -
ID: 49135454