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Clinical translation of the assets of biomedical engineering - a retrospective analysis with looks to the future

Ren, Y., Fagette, P. H., Hall, C. L., Broers, H., Grainger, D. W., Van Der Mei, H. C. & Busscher, H. J., 2-Nov-2019, In : Expert review of medical devices. 16, 11, p. 913-922 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Introduction: Biomedical-engineering (BME) plays a major role in modern medicine. Many BME-based assets have been brought to clinical translation in the twentieth century, but translation currently stagnates. Here, we compare the impact of past and present scientific, economic and societal climates on the translation of BME-based assets, in order to provide the BME-community with incentives to address current stagnation. Areas covered: In the twentieth century, W.J. Kolff brought kidney dialysis, the total artificial heart, artificial vision and limbs to clinical application. This success raises the question whether Kolff and other past giants of clinical translation had special mind-sets, or whether their problem selection, their training, or governmental and regulatory control played roles. Retrospective analysis divides the impact of BME-based assets to clinical application into three periods: 1900-1970: rapid translation from bench-to-bedside, 1970-1990: new diseases and increased governmental control, and the current translational crisis from 1990 onward. Expert opinion: Academic and societal changes can be discerned that are concurrent with BME's translational success: mono-disciplinary versus multi-disciplinary training, academic reward systems based on individual achievements versus team achievements with strong leadership, increased governmental and regulatory control, and industrial involvement. From this, recommendations can be derived for accelerating clinical translation of BME-assets.

Original languageEnglish
Pages (from-to)913-922
Number of pages10
JournalExpert review of medical devices
Volume16
Issue number11
Publication statusPublished - 2-Nov-2019

    Keywords

  • Translational medicine, valorization, biomedical engineering, medical technology, innovation, clinical impact, translational stagnation, DRUG PRICE-COMPETITION, TERM RESTORATION ACT, INCREASING VALUE, HEALTH-CARE, IMPLANT, WASTE, COMPRESSION, PERSPECTIVE, STRATEGIES, INNOVATION

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