Publication

Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries

Jaenisch, T., Dong Thi Hoai Tam, Nguyen Tan Thanh Kieu, Tran Van Ngoc, Nguyen Tran Nam, Nguyen Van Kinh, Yacoub, S., Chanpheaktra, N., Kumar, V., See, L. L. C., Sathar, J., Sandoval, E. P., Maron Alfaro, G. M., Laksono, I. S., Mahendradhata, Y., Sarker, M., Ahmed, F., Caprara, A., Benevides, B. S., Marques, E. T. A., Magalhaes, T., Brasil, P., Netto, M., Tami, A., Bethencourt, S. E., Guzman, M., Simmons, C., Nguyen Thanh Ha Quyen, Merson, L., Nguyen Thi Phuong Dung, Beck, D., Wirths, M., Wolbers, M., Phung Khanh Lam, Rosenberger, K. & Wills, B., 11-Mar-2016, In : BMC Infectious Diseases. 16, 120, 11 p., 120.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Jaenisch, T., Dong Thi Hoai Tam, Nguyen Tan Thanh Kieu, Tran Van Ngoc, Nguyen Tran Nam, Nguyen Van Kinh, ... Wills, B. (2016). Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries. BMC Infectious Diseases, 16(120), [120]. https://doi.org/10.1186/s12879-016-1440-3

Author

Jaenisch, Thomas ; Dong Thi Hoai Tam ; Nguyen Tan Thanh Kieu ; Tran Van Ngoc ; Nguyen Tran Nam ; Nguyen Van Kinh ; Yacoub, Sophie ; Chanpheaktra, Ngoun ; Kumar, Varun ; See, Lucy Lum Chai ; Sathar, Jameela ; Sandoval, Ernesto Pleites ; Maron Alfaro, Gabriela Maria ; Laksono, Ida Safitri ; Mahendradhata, Yodi ; Sarker, Malabika ; Ahmed, Firoz ; Caprara, Andrea ; Benevides, Bruno Souza ; Marques, Ernesto T. A. ; Magalhaes, Tereza ; Brasil, Patricia ; Netto, Marco ; Tami, Adriana ; Bethencourt, Sarah E. ; Guzman, Maria ; Simmons, Cameron ; Nguyen Thanh Ha Quyen ; Merson, Laura ; Nguyen Thi Phuong Dung ; Beck, Dorothea ; Wirths, Marius ; Wolbers, Marcel ; Phung Khanh Lam ; Rosenberger, Kerstin ; Wills, Bridget. / Clinical evaluation of dengue and identification of risk factors for severe disease : protocol for a multicentre study in 8 countries. In: BMC Infectious Diseases. 2016 ; Vol. 16, No. 120.

Harvard

Jaenisch, T, Dong Thi Hoai Tam, Nguyen Tan Thanh Kieu, Tran Van Ngoc, Nguyen Tran Nam, Nguyen Van Kinh, Yacoub, S, Chanpheaktra, N, Kumar, V, See, LLC, Sathar, J, Sandoval, EP, Maron Alfaro, GM, Laksono, IS, Mahendradhata, Y, Sarker, M, Ahmed, F, Caprara, A, Benevides, BS, Marques, ETA, Magalhaes, T, Brasil, P, Netto, M, Tami, A, Bethencourt, SE, Guzman, M, Simmons, C, Nguyen Thanh Ha Quyen, Merson, L, Nguyen Thi Phuong Dung, Beck, D, Wirths, M, Wolbers, M, Phung Khanh Lam, Rosenberger, K & Wills, B 2016, 'Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries', BMC Infectious Diseases, vol. 16, no. 120, 120. https://doi.org/10.1186/s12879-016-1440-3

Standard

Clinical evaluation of dengue and identification of risk factors for severe disease : protocol for a multicentre study in 8 countries. / Jaenisch, Thomas; Dong Thi Hoai Tam; Nguyen Tan Thanh Kieu; Tran Van Ngoc; Nguyen Tran Nam; Nguyen Van Kinh; Yacoub, Sophie; Chanpheaktra, Ngoun; Kumar, Varun; See, Lucy Lum Chai; Sathar, Jameela; Sandoval, Ernesto Pleites; Maron Alfaro, Gabriela Maria; Laksono, Ida Safitri; Mahendradhata, Yodi; Sarker, Malabika; Ahmed, Firoz; Caprara, Andrea; Benevides, Bruno Souza; Marques, Ernesto T. A.; Magalhaes, Tereza; Brasil, Patricia; Netto, Marco; Tami, Adriana; Bethencourt, Sarah E.; Guzman, Maria; Simmons, Cameron; Nguyen Thanh Ha Quyen; Merson, Laura; Nguyen Thi Phuong Dung; Beck, Dorothea; Wirths, Marius; Wolbers, Marcel; Phung Khanh Lam; Rosenberger, Kerstin; Wills, Bridget.

In: BMC Infectious Diseases, Vol. 16, No. 120, 120, 11.03.2016.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Jaenisch T, Dong Thi Hoai Tam, Nguyen Tan Thanh Kieu, Tran Van Ngoc, Nguyen Tran Nam, Nguyen Van Kinh et al. Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries. BMC Infectious Diseases. 2016 Mar 11;16(120). 120. https://doi.org/10.1186/s12879-016-1440-3


BibTeX

@article{aea195468caf4b0dad38a3f5e5ab10a7,
title = "Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries",
abstract = "BACKGROUND: The burden of dengue continues to increase globally, with an estimated 100 million clinically apparent infections occurring each year. Although most dengue infections are asymptomatic, patients can present with a wide spectrum of clinical symptoms ranging from mild febrile illness through to severe manifestations of bleeding, organ impairment, and hypovolaemic shock due to a systemic vascular leak syndrome. Clinical diagnosis of dengue and identification of which patients are likely to develop severe disease remain challenging. This study aims to improve diagnosis and clinical management through approaches designed a) to differentiate between dengue and other common febrile illness within 72 h of fever onset, and b) among patients with dengue to identify markers that are predictive of the likelihood of evolving to a more severe disease course.METHOD/DESIGN: This is a prospective multi-centre observational study aiming to enrol 7-8000 participants aged ≥ 5 years presenting with a febrile illness consistent with dengue to outpatient health facilities in 8 countries across Asia and Latin America. Patients presenting within 72 h of fever onset who do not exhibit signs of severe disease are eligible for the study. A broad range of clinical and laboratory parameters are assessed daily for up to 6 days during the acute illness, and also at a follow up visit 1 week later.DISCUSSION: Data from this large cohort of patients, enrolled early with undifferentiated fever, will be used to develop a practical diagnostic algorithm and a robust clinical case definition for dengue. Additionally, among patients with confirmed dengue we aim to identify simple clinical and laboratory parameters associated with progression to a more severe disease course. We will also investigate early virological and serological correlates of severe disease, and examine genetic associations in this large heterogeneous cohort. In addition the results will be used to assess the new World Health Organization classification scheme for dengue in practice, and to update the guidelines for {"}Integrated Management of Childhood Illness{"} used in dengue-endemic countries.TRIAL REGISTRATION: NCT01550016. Registration Date: March 7, 2012.",
keywords = "Dengue, Asia, Latin America, Diagnosis, Risk prediction, Pathogenesis, HEMORRHAGIC-FEVER, PROTEIN NS1, ANTIBODY-RESPONSE, SHOCK SYNDROME, VIRUS, CLASSIFICATION, INFECTIONS, VIREMIA, CORRELATE, CHILDREN",
author = "Thomas Jaenisch and {Dong Thi Hoai Tam} and {Nguyen Tan Thanh Kieu} and {Tran Van Ngoc} and {Nguyen Tran Nam} and {Nguyen Van Kinh} and Sophie Yacoub and Ngoun Chanpheaktra and Varun Kumar and See, {Lucy Lum Chai} and Jameela Sathar and Sandoval, {Ernesto Pleites} and {Maron Alfaro}, {Gabriela Maria} and Laksono, {Ida Safitri} and Yodi Mahendradhata and Malabika Sarker and Firoz Ahmed and Andrea Caprara and Benevides, {Bruno Souza} and Marques, {Ernesto T. A.} and Tereza Magalhaes and Patricia Brasil and Marco Netto and Adriana Tami and Bethencourt, {Sarah E.} and Maria Guzman and Cameron Simmons and {Nguyen Thanh Ha Quyen} and Laura Merson and {Nguyen Thi Phuong Dung} and Dorothea Beck and Marius Wirths and Marcel Wolbers and {Phung Khanh Lam} and Kerstin Rosenberger and Bridget Wills",
year = "2016",
month = "3",
day = "11",
doi = "10.1186/s12879-016-1440-3",
language = "English",
volume = "16",
journal = "BMC Infectious Diseases",
issn = "1471-2334",
publisher = "BMC",
number = "120",

}

RIS

TY - JOUR

T1 - Clinical evaluation of dengue and identification of risk factors for severe disease

T2 - protocol for a multicentre study in 8 countries

AU - Jaenisch, Thomas

AU - Dong Thi Hoai Tam, null

AU - Nguyen Tan Thanh Kieu, null

AU - Tran Van Ngoc, null

AU - Nguyen Tran Nam, null

AU - Nguyen Van Kinh, null

AU - Yacoub, Sophie

AU - Chanpheaktra, Ngoun

AU - Kumar, Varun

AU - See, Lucy Lum Chai

AU - Sathar, Jameela

AU - Sandoval, Ernesto Pleites

AU - Maron Alfaro, Gabriela Maria

AU - Laksono, Ida Safitri

AU - Mahendradhata, Yodi

AU - Sarker, Malabika

AU - Ahmed, Firoz

AU - Caprara, Andrea

AU - Benevides, Bruno Souza

AU - Marques, Ernesto T. A.

AU - Magalhaes, Tereza

AU - Brasil, Patricia

AU - Netto, Marco

AU - Tami, Adriana

AU - Bethencourt, Sarah E.

AU - Guzman, Maria

AU - Simmons, Cameron

AU - Nguyen Thanh Ha Quyen, null

AU - Merson, Laura

AU - Nguyen Thi Phuong Dung, null

AU - Beck, Dorothea

AU - Wirths, Marius

AU - Wolbers, Marcel

AU - Phung Khanh Lam, null

AU - Rosenberger, Kerstin

AU - Wills, Bridget

PY - 2016/3/11

Y1 - 2016/3/11

N2 - BACKGROUND: The burden of dengue continues to increase globally, with an estimated 100 million clinically apparent infections occurring each year. Although most dengue infections are asymptomatic, patients can present with a wide spectrum of clinical symptoms ranging from mild febrile illness through to severe manifestations of bleeding, organ impairment, and hypovolaemic shock due to a systemic vascular leak syndrome. Clinical diagnosis of dengue and identification of which patients are likely to develop severe disease remain challenging. This study aims to improve diagnosis and clinical management through approaches designed a) to differentiate between dengue and other common febrile illness within 72 h of fever onset, and b) among patients with dengue to identify markers that are predictive of the likelihood of evolving to a more severe disease course.METHOD/DESIGN: This is a prospective multi-centre observational study aiming to enrol 7-8000 participants aged ≥ 5 years presenting with a febrile illness consistent with dengue to outpatient health facilities in 8 countries across Asia and Latin America. Patients presenting within 72 h of fever onset who do not exhibit signs of severe disease are eligible for the study. A broad range of clinical and laboratory parameters are assessed daily for up to 6 days during the acute illness, and also at a follow up visit 1 week later.DISCUSSION: Data from this large cohort of patients, enrolled early with undifferentiated fever, will be used to develop a practical diagnostic algorithm and a robust clinical case definition for dengue. Additionally, among patients with confirmed dengue we aim to identify simple clinical and laboratory parameters associated with progression to a more severe disease course. We will also investigate early virological and serological correlates of severe disease, and examine genetic associations in this large heterogeneous cohort. In addition the results will be used to assess the new World Health Organization classification scheme for dengue in practice, and to update the guidelines for "Integrated Management of Childhood Illness" used in dengue-endemic countries.TRIAL REGISTRATION: NCT01550016. Registration Date: March 7, 2012.

AB - BACKGROUND: The burden of dengue continues to increase globally, with an estimated 100 million clinically apparent infections occurring each year. Although most dengue infections are asymptomatic, patients can present with a wide spectrum of clinical symptoms ranging from mild febrile illness through to severe manifestations of bleeding, organ impairment, and hypovolaemic shock due to a systemic vascular leak syndrome. Clinical diagnosis of dengue and identification of which patients are likely to develop severe disease remain challenging. This study aims to improve diagnosis and clinical management through approaches designed a) to differentiate between dengue and other common febrile illness within 72 h of fever onset, and b) among patients with dengue to identify markers that are predictive of the likelihood of evolving to a more severe disease course.METHOD/DESIGN: This is a prospective multi-centre observational study aiming to enrol 7-8000 participants aged ≥ 5 years presenting with a febrile illness consistent with dengue to outpatient health facilities in 8 countries across Asia and Latin America. Patients presenting within 72 h of fever onset who do not exhibit signs of severe disease are eligible for the study. A broad range of clinical and laboratory parameters are assessed daily for up to 6 days during the acute illness, and also at a follow up visit 1 week later.DISCUSSION: Data from this large cohort of patients, enrolled early with undifferentiated fever, will be used to develop a practical diagnostic algorithm and a robust clinical case definition for dengue. Additionally, among patients with confirmed dengue we aim to identify simple clinical and laboratory parameters associated with progression to a more severe disease course. We will also investigate early virological and serological correlates of severe disease, and examine genetic associations in this large heterogeneous cohort. In addition the results will be used to assess the new World Health Organization classification scheme for dengue in practice, and to update the guidelines for "Integrated Management of Childhood Illness" used in dengue-endemic countries.TRIAL REGISTRATION: NCT01550016. Registration Date: March 7, 2012.

KW - Dengue

KW - Asia

KW - Latin America

KW - Diagnosis

KW - Risk prediction

KW - Pathogenesis

KW - HEMORRHAGIC-FEVER

KW - PROTEIN NS1

KW - ANTIBODY-RESPONSE

KW - SHOCK SYNDROME

KW - VIRUS

KW - CLASSIFICATION

KW - INFECTIONS

KW - VIREMIA

KW - CORRELATE

KW - CHILDREN

U2 - 10.1186/s12879-016-1440-3

DO - 10.1186/s12879-016-1440-3

M3 - Article

VL - 16

JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

SN - 1471-2334

IS - 120

M1 - 120

ER -

ID: 33829575