Publication

Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis - A dual-center, double-blind placebo-controlled study

Winkel, EG., Roldan, S., Van Winkelhoff, AJ., Herrera, D. & Sanz, M., Apr-2003, In : Journal of Clinical Periodontology. 30, 4, p. 300-306 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Winkel, EG., Roldan, S., Van Winkelhoff, AJ., Herrera, D., & Sanz, M. (2003). Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis - A dual-center, double-blind placebo-controlled study. Journal of Clinical Periodontology, 30(4), 300-306.

Author

Winkel, EG ; Roldan, S ; Van Winkelhoff, AJ ; Herrera, D ; Sanz, M. / Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis - A dual-center, double-blind placebo-controlled study. In: Journal of Clinical Periodontology. 2003 ; Vol. 30, No. 4. pp. 300-306.

Harvard

Winkel, EG, Roldan, S, Van Winkelhoff, AJ, Herrera, D & Sanz, M 2003, 'Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis - A dual-center, double-blind placebo-controlled study', Journal of Clinical Periodontology, vol. 30, no. 4, pp. 300-306.

Standard

Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis - A dual-center, double-blind placebo-controlled study. / Winkel, EG; Roldan, S; Van Winkelhoff, AJ; Herrera, D; Sanz, M.

In: Journal of Clinical Periodontology, Vol. 30, No. 4, 04.2003, p. 300-306.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Winkel EG, Roldan S, Van Winkelhoff AJ, Herrera D, Sanz M. Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis - A dual-center, double-blind placebo-controlled study. Journal of Clinical Periodontology. 2003 Apr;30(4):300-306.


BibTeX

@article{7a1912884a6446a1ac6e4986ef1abad2,
title = "Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis - A dual-center, double-blind placebo-controlled study",
abstract = "Objectives: The aim of this double-blind, parallel study was to test the clinical efficacy of a newly developed mouthrinse in the treatment of oral halitosis in patients without periodontitis.Material and methods: Forty volunteers, recruited in two centers, participated in this study. Patients were selected on the basis of (1) halitosis of oral origin, (2) full-mouth organoleptic score >1, using an arbitrary 0-5 scale, (3) level of volatile sulfur compounds (VSC) >170 parts per billion (ppb) and (4) Winkel tongue coating index (WTCI) > 4 (0-12). Intervention included gargling with a mouthrinse containing chlorhexidine (0.05%), cetylpyridinium chloride (0.05%) and zinc-lactate (0.14%) or with a placebo mouthrinse without active ingredients. At days 0 and 14 clinical variables were assessed in order of performance: (1) organoleptic assessments, (2) levels of VSC, and (3) WTCI.Results: Treatment with the active mouthrinse resulted in a significant mean reduction in the organoleptic score from 2.8 to 1.5 (p <0.005). In the placebo group, no significant reduction in the mean organoleptic score occurred. Consequently, this resulted, after 2 weeks, in a greater change of the organoleptic scores in the test group in comparison to the placebo group (p <0.005). The mean VSC scores were reduced from 292 to 172 ppb in the test group (p <0.005), whereas no reduction was observed in the placebo group. At the 2-week examination, the mean change of the VSC scores in the test group was significantly greater than the mean change in the placebo group (p <0.005). Neither in the test nor in the placebo group a significant reduction in tongue coating was observed.Conclusions: In conclusion, the tested mouthrinse is effective in the treatment of oral halitosis.",
keywords = "halitosis, volatile sulfur compounds, chlorhexidine, cetylpyridinium chloride, zinc-lactate, mouthrinse, double-blind placebo-controlled study, VOLATILE SULFUR-COMPOUNDS, SALIVARY-GLAND HYPOFUNCTION, OIL-WATER MOUTHRINSE, SULFIDE MONITOR, FLUID BALANCE, BREATH-ODOR, MALODOR, REDUCTION, PERIODONTITIS, CONSUMPTION",
author = "EG Winkel and S Roldan and {Van Winkelhoff}, AJ and D Herrera and M Sanz",
year = "2003",
month = apr,
language = "English",
volume = "30",
pages = "300--306",
journal = "Journal of Clinical Periodontology",
issn = "0303-6979",
publisher = "Wiley",
number = "4",

}

RIS

TY - JOUR

T1 - Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis - A dual-center, double-blind placebo-controlled study

AU - Winkel, EG

AU - Roldan, S

AU - Van Winkelhoff, AJ

AU - Herrera, D

AU - Sanz, M

PY - 2003/4

Y1 - 2003/4

N2 - Objectives: The aim of this double-blind, parallel study was to test the clinical efficacy of a newly developed mouthrinse in the treatment of oral halitosis in patients without periodontitis.Material and methods: Forty volunteers, recruited in two centers, participated in this study. Patients were selected on the basis of (1) halitosis of oral origin, (2) full-mouth organoleptic score >1, using an arbitrary 0-5 scale, (3) level of volatile sulfur compounds (VSC) >170 parts per billion (ppb) and (4) Winkel tongue coating index (WTCI) > 4 (0-12). Intervention included gargling with a mouthrinse containing chlorhexidine (0.05%), cetylpyridinium chloride (0.05%) and zinc-lactate (0.14%) or with a placebo mouthrinse without active ingredients. At days 0 and 14 clinical variables were assessed in order of performance: (1) organoleptic assessments, (2) levels of VSC, and (3) WTCI.Results: Treatment with the active mouthrinse resulted in a significant mean reduction in the organoleptic score from 2.8 to 1.5 (p <0.005). In the placebo group, no significant reduction in the mean organoleptic score occurred. Consequently, this resulted, after 2 weeks, in a greater change of the organoleptic scores in the test group in comparison to the placebo group (p <0.005). The mean VSC scores were reduced from 292 to 172 ppb in the test group (p <0.005), whereas no reduction was observed in the placebo group. At the 2-week examination, the mean change of the VSC scores in the test group was significantly greater than the mean change in the placebo group (p <0.005). Neither in the test nor in the placebo group a significant reduction in tongue coating was observed.Conclusions: In conclusion, the tested mouthrinse is effective in the treatment of oral halitosis.

AB - Objectives: The aim of this double-blind, parallel study was to test the clinical efficacy of a newly developed mouthrinse in the treatment of oral halitosis in patients without periodontitis.Material and methods: Forty volunteers, recruited in two centers, participated in this study. Patients were selected on the basis of (1) halitosis of oral origin, (2) full-mouth organoleptic score >1, using an arbitrary 0-5 scale, (3) level of volatile sulfur compounds (VSC) >170 parts per billion (ppb) and (4) Winkel tongue coating index (WTCI) > 4 (0-12). Intervention included gargling with a mouthrinse containing chlorhexidine (0.05%), cetylpyridinium chloride (0.05%) and zinc-lactate (0.14%) or with a placebo mouthrinse without active ingredients. At days 0 and 14 clinical variables were assessed in order of performance: (1) organoleptic assessments, (2) levels of VSC, and (3) WTCI.Results: Treatment with the active mouthrinse resulted in a significant mean reduction in the organoleptic score from 2.8 to 1.5 (p <0.005). In the placebo group, no significant reduction in the mean organoleptic score occurred. Consequently, this resulted, after 2 weeks, in a greater change of the organoleptic scores in the test group in comparison to the placebo group (p <0.005). The mean VSC scores were reduced from 292 to 172 ppb in the test group (p <0.005), whereas no reduction was observed in the placebo group. At the 2-week examination, the mean change of the VSC scores in the test group was significantly greater than the mean change in the placebo group (p <0.005). Neither in the test nor in the placebo group a significant reduction in tongue coating was observed.Conclusions: In conclusion, the tested mouthrinse is effective in the treatment of oral halitosis.

KW - halitosis

KW - volatile sulfur compounds

KW - chlorhexidine

KW - cetylpyridinium chloride

KW - zinc-lactate

KW - mouthrinse

KW - double-blind placebo-controlled study

KW - VOLATILE SULFUR-COMPOUNDS

KW - SALIVARY-GLAND HYPOFUNCTION

KW - OIL-WATER MOUTHRINSE

KW - SULFIDE MONITOR

KW - FLUID BALANCE

KW - BREATH-ODOR

KW - MALODOR

KW - REDUCTION

KW - PERIODONTITIS

KW - CONSUMPTION

M3 - Article

VL - 30

SP - 300

EP - 306

JO - Journal of Clinical Periodontology

JF - Journal of Clinical Periodontology

SN - 0303-6979

IS - 4

ER -

ID: 13928033