Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis - A dual-center, double-blind placebo-controlled studyWinkel, EG., Roldan, S., Van Winkelhoff, AJ., Herrera, D. & Sanz, M., Apr-2003, In : Journal of Clinical Periodontology. 30, 4, p. 300-306 7 p.
Research output: Contribution to journal › Article › Academic › peer-review
Objectives: The aim of this double-blind, parallel study was to test the clinical efficacy of a newly developed mouthrinse in the treatment of oral halitosis in patients without periodontitis.
Material and methods: Forty volunteers, recruited in two centers, participated in this study. Patients were selected on the basis of (1) halitosis of oral origin, (2) full-mouth organoleptic score >1, using an arbitrary 0-5 scale, (3) level of volatile sulfur compounds (VSC) >170 parts per billion (ppb) and (4) Winkel tongue coating index (WTCI) > 4 (0-12). Intervention included gargling with a mouthrinse containing chlorhexidine (0.05%), cetylpyridinium chloride (0.05%) and zinc-lactate (0.14%) or with a placebo mouthrinse without active ingredients. At days 0 and 14 clinical variables were assessed in order of performance: (1) organoleptic assessments, (2) levels of VSC, and (3) WTCI.
Results: Treatment with the active mouthrinse resulted in a significant mean reduction in the organoleptic score from 2.8 to 1.5 (p <0.005). In the placebo group, no significant reduction in the mean organoleptic score occurred. Consequently, this resulted, after 2 weeks, in a greater change of the organoleptic scores in the test group in comparison to the placebo group (p <0.005). The mean VSC scores were reduced from 292 to 172 ppb in the test group (p <0.005), whereas no reduction was observed in the placebo group. At the 2-week examination, the mean change of the VSC scores in the test group was significantly greater than the mean change in the placebo group (p <0.005). Neither in the test nor in the placebo group a significant reduction in tongue coating was observed.
Conclusions: In conclusion, the tested mouthrinse is effective in the treatment of oral halitosis.
|Number of pages||7|
|Journal||Journal of Clinical Periodontology|
|Publication status||Published - Apr-2003|
- halitosis, volatile sulfur compounds, chlorhexidine, cetylpyridinium chloride, zinc-lactate, mouthrinse, double-blind placebo-controlled study, VOLATILE SULFUR-COMPOUNDS, SALIVARY-GLAND HYPOFUNCTION, OIL-WATER MOUTHRINSE, SULFIDE MONITOR, FLUID BALANCE, BREATH-ODOR, MALODOR, REDUCTION, PERIODONTITIS, CONSUMPTION