Clinical course of recurrent respiratory papillomatosis: Comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11Tjon Pian Gi, R. E. A., San Giorgi, M. R. M., Slagter-Menkema, L., van Hemel, B. M., van der Laan, B. F. A. M., van den Heuvel, E. R., Dikkers, F. G. & Schuuring, E. M. D., Nov-2015, In : Journal of the Sciences and Specialties of the Head and Neck. 37, 11, p. 1625-1632 8 p.
Research output: Contribution to journal › Article › Academic › peer-review
Background. Recurrent respiratory papillomatosis (RRP) is mainly associated with human papillomavirus (HPV) 6 or HPV11. The purpose of this study was to compare clinical outcome, aggressiveness, and treatment response between HPV6- and HPV11-associated RRP.
Methods. A retrospective cohort of 55 patients with RRP (1974-2012) was used. Surgical interventions (n = 814) were analyzed, and complications scored. HPV6/11-specific polymerase chain reaction (PCR) was performed on RRP biopsies.
Results. Seventy-six percent of patients (42 of 55) were infected with HPV6 and 24% (13 of 55) with HPV11. The HPV11 group had anatomically more widespread disease. The expected number of surgical interventions was higher in the younger age (
Conclusion. Anatomically, HPV11-associated RRP behaves more aggressively. Younger patients with HPV11 and older patients with HPV6 experience a worse clinical course of RRP. (C) 2014 Wiley Periodicals, Inc.
|Number of pages||8|
|Journal||Journal of the Sciences and Specialties of the Head and Neck|
|Publication status||Published - Nov-2015|
- human papillomavirus, HPV6, HPV11, HPV, recurrent respiratory papillomatosis, clinical course, SQUAMOUS-CELL CARCINOMA, MALIGNANT-TRANSFORMATION, RISK-FACTORS, ONSET, POPULATION, IDENTIFICATION, PREVALENCE, PREDICTORS, EXPERIENCE