Publication

Clinical and neurohumoral associates of variations in plasma Na+ in the PREVEND cohort

Hessels, N. R., van den Bosch, J. J. O. N., van Londen, M., Bakker, S. J. L., Riphagen, I. J. & Navis, G. J., Oct-2019, In : American journal of physiology-Renal physiology. 317, 4, p. F978-F985 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Hessels, N. R., van den Bosch, J. J. O. N., van Londen, M., Bakker, S. J. L., Riphagen, I. J., & Navis, G. J. (2019). Clinical and neurohumoral associates of variations in plasma Na+ in the PREVEND cohort. American journal of physiology-Renal physiology, 317(4), F978-F985. https://doi.org/10.1152/ajprenal.00465.2018

Author

Hessels, Niek R. ; van den Bosch, Jacqueline J. O. N. ; van Londen, Marco ; Bakker, Stephan J. L. ; Riphagen, Ineke J. ; Navis, Gerjan J. / Clinical and neurohumoral associates of variations in plasma Na+ in the PREVEND cohort. In: American journal of physiology-Renal physiology. 2019 ; Vol. 317, No. 4. pp. F978-F985.

Harvard

Hessels, NR, van den Bosch, JJON, van Londen, M, Bakker, SJL, Riphagen, IJ & Navis, GJ 2019, 'Clinical and neurohumoral associates of variations in plasma Na+ in the PREVEND cohort', American journal of physiology-Renal physiology, vol. 317, no. 4, pp. F978-F985. https://doi.org/10.1152/ajprenal.00465.2018

Standard

Clinical and neurohumoral associates of variations in plasma Na+ in the PREVEND cohort. / Hessels, Niek R.; van den Bosch, Jacqueline J. O. N.; van Londen, Marco; Bakker, Stephan J. L.; Riphagen, Ineke J.; Navis, Gerjan J.

In: American journal of physiology-Renal physiology, Vol. 317, No. 4, 10.2019, p. F978-F985.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Hessels NR, van den Bosch JJON, van Londen M, Bakker SJL, Riphagen IJ, Navis GJ. Clinical and neurohumoral associates of variations in plasma Na+ in the PREVEND cohort. American journal of physiology-Renal physiology. 2019 Oct;317(4):F978-F985. https://doi.org/10.1152/ajprenal.00465.2018


BibTeX

@article{3bcdf0a1644c43b0b1d2c0d09d59963f,
title = "Clinical and neurohumoral associates of variations in plasma Na+ in the PREVEND cohort",
abstract = "Plasma Na+ concentration is regulated within narrow limits. Yet, substantial interindividual differences exist even in the normal range. The determinants of these differences are not well understood. We therefore investigated the clinical and neurohumoral associates of plasma Na+. We studied 2,364 men (age: 48 +/- 12 yr) and 2,710 women (age: 47 +/- 12 yr) from the prospective Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort study. In the present study, we investigated the neurohumoral factors NH2-terminal prohormone of brain natriuretic peptide (NT-proBNP) and aldosterone as volume markers and copeptin as a marker for osmoregulation. Clinical associating variables of plasma Na+ were age, sex, and plasma glucose. Furthermore, plasma Na+ levels were associated with log(2) copeptin (men: standardized beta = 0.18, P <0.001; women: standardized beta = 0.17, P <0.001), log(2) NT-proBNP (men: standardized beta = 0.07, P = 0.008; women: standardized beta = 0.12, P <0.001), and log(2) aldosterone (men: standardized beta = -0.06, P = 0.005; women: standardized beta = -0.09, P <0.001). Copeptin and NT-proBNP showed an interaction in their association with plasma Na+. Thus, our data 1) support that osmo-regulation, as estimated from copeptin levels, is a main associate of plasma Na+; 2) show a consistent association with volume markers, with higher NT-proBNP and lower aldosterone in individuals with higher plasma Na+; and 3) show that the interaction between copeptin and NT-proBNP illustrates that osmoregulation and volume regulation act in concert in the regulation of plasma Na+.",
keywords = "aldosterone, copeptin, NH2-terminal prohormone of brain natriuretic peptide, plasma sodium, Prevention of Renal and Vascular End-Stage Disease, SERUM CONSTITUENTS, ANALYTIC COMPONENTS, BLOOD-PRESSURE, LONG-TERM, SODIUM, RISK, HERITABILITY, SECRETION",
author = "Hessels, {Niek R.} and {van den Bosch}, {Jacqueline J. O. N.} and {van Londen}, Marco and Bakker, {Stephan J. L.} and Riphagen, {Ineke J.} and Navis, {Gerjan J.}",
year = "2019",
month = "10",
doi = "10.1152/ajprenal.00465.2018",
language = "English",
volume = "317",
pages = "F978--F985",
journal = "American journal of physiology-Renal physiology",
issn = "1931-857X",
publisher = "AMER PHYSIOLOGICAL SOC",
number = "4",

}

RIS

TY - JOUR

T1 - Clinical and neurohumoral associates of variations in plasma Na+ in the PREVEND cohort

AU - Hessels, Niek R.

AU - van den Bosch, Jacqueline J. O. N.

AU - van Londen, Marco

AU - Bakker, Stephan J. L.

AU - Riphagen, Ineke J.

AU - Navis, Gerjan J.

PY - 2019/10

Y1 - 2019/10

N2 - Plasma Na+ concentration is regulated within narrow limits. Yet, substantial interindividual differences exist even in the normal range. The determinants of these differences are not well understood. We therefore investigated the clinical and neurohumoral associates of plasma Na+. We studied 2,364 men (age: 48 +/- 12 yr) and 2,710 women (age: 47 +/- 12 yr) from the prospective Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort study. In the present study, we investigated the neurohumoral factors NH2-terminal prohormone of brain natriuretic peptide (NT-proBNP) and aldosterone as volume markers and copeptin as a marker for osmoregulation. Clinical associating variables of plasma Na+ were age, sex, and plasma glucose. Furthermore, plasma Na+ levels were associated with log(2) copeptin (men: standardized beta = 0.18, P <0.001; women: standardized beta = 0.17, P <0.001), log(2) NT-proBNP (men: standardized beta = 0.07, P = 0.008; women: standardized beta = 0.12, P <0.001), and log(2) aldosterone (men: standardized beta = -0.06, P = 0.005; women: standardized beta = -0.09, P <0.001). Copeptin and NT-proBNP showed an interaction in their association with plasma Na+. Thus, our data 1) support that osmo-regulation, as estimated from copeptin levels, is a main associate of plasma Na+; 2) show a consistent association with volume markers, with higher NT-proBNP and lower aldosterone in individuals with higher plasma Na+; and 3) show that the interaction between copeptin and NT-proBNP illustrates that osmoregulation and volume regulation act in concert in the regulation of plasma Na+.

AB - Plasma Na+ concentration is regulated within narrow limits. Yet, substantial interindividual differences exist even in the normal range. The determinants of these differences are not well understood. We therefore investigated the clinical and neurohumoral associates of plasma Na+. We studied 2,364 men (age: 48 +/- 12 yr) and 2,710 women (age: 47 +/- 12 yr) from the prospective Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort study. In the present study, we investigated the neurohumoral factors NH2-terminal prohormone of brain natriuretic peptide (NT-proBNP) and aldosterone as volume markers and copeptin as a marker for osmoregulation. Clinical associating variables of plasma Na+ were age, sex, and plasma glucose. Furthermore, plasma Na+ levels were associated with log(2) copeptin (men: standardized beta = 0.18, P <0.001; women: standardized beta = 0.17, P <0.001), log(2) NT-proBNP (men: standardized beta = 0.07, P = 0.008; women: standardized beta = 0.12, P <0.001), and log(2) aldosterone (men: standardized beta = -0.06, P = 0.005; women: standardized beta = -0.09, P <0.001). Copeptin and NT-proBNP showed an interaction in their association with plasma Na+. Thus, our data 1) support that osmo-regulation, as estimated from copeptin levels, is a main associate of plasma Na+; 2) show a consistent association with volume markers, with higher NT-proBNP and lower aldosterone in individuals with higher plasma Na+; and 3) show that the interaction between copeptin and NT-proBNP illustrates that osmoregulation and volume regulation act in concert in the regulation of plasma Na+.

KW - aldosterone

KW - copeptin

KW - NH2-terminal prohormone of brain natriuretic peptide

KW - plasma sodium

KW - Prevention of Renal and Vascular End-Stage Disease

KW - SERUM CONSTITUENTS

KW - ANALYTIC COMPONENTS

KW - BLOOD-PRESSURE

KW - LONG-TERM

KW - SODIUM

KW - RISK

KW - HERITABILITY

KW - SECRETION

U2 - 10.1152/ajprenal.00465.2018

DO - 10.1152/ajprenal.00465.2018

M3 - Article

VL - 317

SP - F978-F985

JO - American journal of physiology-Renal physiology

JF - American journal of physiology-Renal physiology

SN - 1931-857X

IS - 4

ER -

ID: 99960125