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Classification of α-synuclein-induced changes in the AAV α-synuclein rat model of Parkinson's disease using electrophysiological measurements of visual processing

Ostergaard, F. G., Himmelberg, M. M., Laursen, B., Siebner, H. R., Wade, A. R. & Christensen, K. V., 17-Jul-2020, In : Scientific Reports. 10, 1, 14 p., 11869.

Research output: Contribution to journalArticleAcademicpeer-review

  • Freja Gam Ostergaard
  • Marc M. Himmelberg
  • Bettina Laursen
  • Hartwig R. Siebner
  • Alex R. Wade
  • Kenneth Vielsted Christensen

Biomarkers suitable for early diagnosis and monitoring disease progression are the cornerstone of developing disease-modifying treatments for neurodegenerative diseases such as Parkinson’s disease (PD). Besides motor complications, PD is also characterized by deficits in visual processing. Here, we investigate how virally-mediated overexpression of α-synuclein in the substantia nigra pars compacta impacts visual processing in a well-established rodent model of PD. After a unilateral injection of vector, human α-synuclein was detected in the striatum and superior colliculus (SC). In parallel, there was a significant delay in the latency of the transient VEPs from the affected side of the SC in late stages of the disease. Inhibition of leucine-rich repeat kinase using PFE360 failed to rescue the VEP delay and instead increased the latency of the VEP waveform. A support vector machine classifier accurately classified rats according to their `disease state’ using frequency-domain data from steady-state visual evoked potentials (SSVEP). Overall, these findings indicate that the latency of the rodent VEP is sensitive to changes mediated by the increased expression of α-synuclein and especially when full overexpression is obtained, whereas the SSVEP facilitated detection of α-synuclein across reflects all stages of PD model progression.

Original languageEnglish
Article number11869
Number of pages14
JournalScientific Reports
Volume10
Issue number1
Publication statusPublished - 17-Jul-2020

    Keywords

  • SUBSTANTIA-NIGRA, SUPERIOR COLLICULUS, EVOKED-POTENTIALS, GAIN-CONTROL, PROJECTION, PATHOLOGY, DOPAMINE

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