Publication

Circulating Advanced Glycation Endproducts and Long-Term Risk of Cardiovascular Mortality in Kidney Transplant Recipients

Sotomayor, C. G., Gomes-Neto, A. W., van Londen, M., Gans, R. O. B., Nolte, I. M., Berger, S. P., Navis, G. J., Rodrigo, R., Leuvenink, H. G. D., Schalkwijk, C. G. & Bakker, S. J. L., 7-Oct-2019, In : Clinical Journal of the American Society of Nephrology. 14, 10, p. 1512-1520 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Sotomayor, C. G., Gomes-Neto, A. W., van Londen, M., Gans, R. O. B., Nolte, I. M., Berger, S. P., ... Bakker, S. J. L. (2019). Circulating Advanced Glycation Endproducts and Long-Term Risk of Cardiovascular Mortality in Kidney Transplant Recipients. Clinical Journal of the American Society of Nephrology, 14(10), 1512-1520. https://doi.org/10.2215/CJN.00540119

Author

Sotomayor, Camilo G ; Gomes-Neto, António W ; van Londen, Marco ; Gans, Rijk O B ; Nolte, Ilja M ; Berger, Stefan P ; Navis, Gerjan J ; Rodrigo, Ramón ; Leuvenink, Henri G D ; Schalkwijk, Casper G ; Bakker, Stephan J L. / Circulating Advanced Glycation Endproducts and Long-Term Risk of Cardiovascular Mortality in Kidney Transplant Recipients. In: Clinical Journal of the American Society of Nephrology. 2019 ; Vol. 14, No. 10. pp. 1512-1520.

Harvard

Sotomayor, CG, Gomes-Neto, AW, van Londen, M, Gans, ROB, Nolte, IM, Berger, SP, Navis, GJ, Rodrigo, R, Leuvenink, HGD, Schalkwijk, CG & Bakker, SJL 2019, 'Circulating Advanced Glycation Endproducts and Long-Term Risk of Cardiovascular Mortality in Kidney Transplant Recipients', Clinical Journal of the American Society of Nephrology, vol. 14, no. 10, pp. 1512-1520. https://doi.org/10.2215/CJN.00540119

Standard

Circulating Advanced Glycation Endproducts and Long-Term Risk of Cardiovascular Mortality in Kidney Transplant Recipients. / Sotomayor, Camilo G; Gomes-Neto, António W; van Londen, Marco; Gans, Rijk O B; Nolte, Ilja M; Berger, Stefan P; Navis, Gerjan J; Rodrigo, Ramón; Leuvenink, Henri G D; Schalkwijk, Casper G; Bakker, Stephan J L.

In: Clinical Journal of the American Society of Nephrology, Vol. 14, No. 10, 07.10.2019, p. 1512-1520.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Sotomayor CG, Gomes-Neto AW, van Londen M, Gans ROB, Nolte IM, Berger SP et al. Circulating Advanced Glycation Endproducts and Long-Term Risk of Cardiovascular Mortality in Kidney Transplant Recipients. Clinical Journal of the American Society of Nephrology. 2019 Oct 7;14(10):1512-1520. https://doi.org/10.2215/CJN.00540119


BibTeX

@article{7b3d05eee5c74039a1f31786f3d83cfc,
title = "Circulating Advanced Glycation Endproducts and Long-Term Risk of Cardiovascular Mortality in Kidney Transplant Recipients",
abstract = "Background and objectives In kidney transplant recipients, elevated circulating advanced glycation endproducts (AGEs) are the result of increased formation and decreased kidney clearance. AGEs trigger several intracellular mechanisms that ultimately yield excess cardiovascular disease. We hypothesized that, in stable kidney transplant recipients, circulating AGEs are associated with long-term risk of cardiovascular mortality, and that such a relationship is mediated by inflammatory, oxidative stress, and endothelial dysfunction biomarkers.Design, setting, participants, & measurements Prospective cohort study of stable kidney transplant recipients recruited between 2001 and 2003 in a university setting. We performed multivariable-adjusted Cox regression analyses to assess the association of AGEs (i.e., N-epsilon-[Carboxymethyl]lysine (CML) and N-epsilon-[Carboxyethyl]lysine (CEL), measured by tandem mass spectrometry) with cardiovascular mortality. Mediation analyses were performed according to Preacher and Hayes's procedure.Results We included 555 kidney transplant recipients (age 51-12 years, 56{\%} men). During a median follow-up of 6.9 years, 122 kidney transplant recipients died (52{\%} deaths were due to cardiovascular causes). CML and CEL concentrations were directly associated with cardiovascular mortality (respectively, hazard ratio, 1.55; 95{\%} confidence interval, 1.24 to 1.95; PConclusions In stable kidney transplant recipients, circulating levels of AGEs are independently associated with long- term risk of cardiovascular mortality.",
keywords = "advanced glycation end-product, cardiovascular mortality, renal transplantation, oxidative stress, endothelial dysfunction, humans, area under curve, ROC curve, Glycation End Products, Advanced, confidence interval, Transplantation, Homologous, kidney transplantation, allografts, kidney diseases, kidney disease, fibrosis, biopsy, kidney biopsy, magnetic resonance imaging, hypoxia, glomerulonephritis, oxygen, cardiovascular disease, cohort studies, END-PRODUCTS, N-EPSILON-(CARBOXYMETHYL) LYSINE, ENDOTHELIAL DYSFUNCTION, PREDICTS MORTALITY, OXIDANT STRESS, ACCUMULATION, INFLAMMATION, CREATININE, SURVIVAL, DISEASE",
author = "Sotomayor, {Camilo G} and Gomes-Neto, {Ant{\'o}nio W} and {van Londen}, Marco and Gans, {Rijk O B} and Nolte, {Ilja M} and Berger, {Stefan P} and Navis, {Gerjan J} and Ram{\'o}n Rodrigo and Leuvenink, {Henri G D} and Schalkwijk, {Casper G} and Bakker, {Stephan J L}",
note = "Copyright {\circledC} 2019 by the American Society of Nephrology.",
year = "2019",
month = "10",
day = "7",
doi = "10.2215/CJN.00540119",
language = "English",
volume = "14",
pages = "1512--1520",
journal = "Clinical Journal of the American Society of Nephrology",
issn = "1555-9041",
publisher = "AMER SOC NEPHROLOGY",
number = "10",

}

RIS

TY - JOUR

T1 - Circulating Advanced Glycation Endproducts and Long-Term Risk of Cardiovascular Mortality in Kidney Transplant Recipients

AU - Sotomayor, Camilo G

AU - Gomes-Neto, António W

AU - van Londen, Marco

AU - Gans, Rijk O B

AU - Nolte, Ilja M

AU - Berger, Stefan P

AU - Navis, Gerjan J

AU - Rodrigo, Ramón

AU - Leuvenink, Henri G D

AU - Schalkwijk, Casper G

AU - Bakker, Stephan J L

N1 - Copyright © 2019 by the American Society of Nephrology.

PY - 2019/10/7

Y1 - 2019/10/7

N2 - Background and objectives In kidney transplant recipients, elevated circulating advanced glycation endproducts (AGEs) are the result of increased formation and decreased kidney clearance. AGEs trigger several intracellular mechanisms that ultimately yield excess cardiovascular disease. We hypothesized that, in stable kidney transplant recipients, circulating AGEs are associated with long-term risk of cardiovascular mortality, and that such a relationship is mediated by inflammatory, oxidative stress, and endothelial dysfunction biomarkers.Design, setting, participants, & measurements Prospective cohort study of stable kidney transplant recipients recruited between 2001 and 2003 in a university setting. We performed multivariable-adjusted Cox regression analyses to assess the association of AGEs (i.e., N-epsilon-[Carboxymethyl]lysine (CML) and N-epsilon-[Carboxyethyl]lysine (CEL), measured by tandem mass spectrometry) with cardiovascular mortality. Mediation analyses were performed according to Preacher and Hayes's procedure.Results We included 555 kidney transplant recipients (age 51-12 years, 56% men). During a median follow-up of 6.9 years, 122 kidney transplant recipients died (52% deaths were due to cardiovascular causes). CML and CEL concentrations were directly associated with cardiovascular mortality (respectively, hazard ratio, 1.55; 95% confidence interval, 1.24 to 1.95; PConclusions In stable kidney transplant recipients, circulating levels of AGEs are independently associated with long- term risk of cardiovascular mortality.

AB - Background and objectives In kidney transplant recipients, elevated circulating advanced glycation endproducts (AGEs) are the result of increased formation and decreased kidney clearance. AGEs trigger several intracellular mechanisms that ultimately yield excess cardiovascular disease. We hypothesized that, in stable kidney transplant recipients, circulating AGEs are associated with long-term risk of cardiovascular mortality, and that such a relationship is mediated by inflammatory, oxidative stress, and endothelial dysfunction biomarkers.Design, setting, participants, & measurements Prospective cohort study of stable kidney transplant recipients recruited between 2001 and 2003 in a university setting. We performed multivariable-adjusted Cox regression analyses to assess the association of AGEs (i.e., N-epsilon-[Carboxymethyl]lysine (CML) and N-epsilon-[Carboxyethyl]lysine (CEL), measured by tandem mass spectrometry) with cardiovascular mortality. Mediation analyses were performed according to Preacher and Hayes's procedure.Results We included 555 kidney transplant recipients (age 51-12 years, 56% men). During a median follow-up of 6.9 years, 122 kidney transplant recipients died (52% deaths were due to cardiovascular causes). CML and CEL concentrations were directly associated with cardiovascular mortality (respectively, hazard ratio, 1.55; 95% confidence interval, 1.24 to 1.95; PConclusions In stable kidney transplant recipients, circulating levels of AGEs are independently associated with long- term risk of cardiovascular mortality.

KW - advanced glycation end-product

KW - cardiovascular mortality

KW - renal transplantation

KW - oxidative stress

KW - endothelial dysfunction

KW - humans

KW - area under curve

KW - ROC curve

KW - Glycation End Products

KW - Advanced

KW - confidence interval

KW - Transplantation

KW - Homologous

KW - kidney transplantation

KW - allografts

KW - kidney diseases

KW - kidney disease

KW - fibrosis

KW - biopsy

KW - kidney biopsy

KW - magnetic resonance imaging

KW - hypoxia

KW - glomerulonephritis

KW - oxygen

KW - cardiovascular disease

KW - cohort studies

KW - END-PRODUCTS

KW - N-EPSILON-(CARBOXYMETHYL) LYSINE

KW - ENDOTHELIAL DYSFUNCTION

KW - PREDICTS MORTALITY

KW - OXIDANT STRESS

KW - ACCUMULATION

KW - INFLAMMATION

KW - CREATININE

KW - SURVIVAL

KW - DISEASE

U2 - 10.2215/CJN.00540119

DO - 10.2215/CJN.00540119

M3 - Article

VL - 14

SP - 1512

EP - 1520

JO - Clinical Journal of the American Society of Nephrology

JF - Clinical Journal of the American Society of Nephrology

SN - 1555-9041

IS - 10

ER -

ID: 97342115