Publication

CIN and Aneuploidy: Different Concepts, Different Consequences

Schukken, K. M. & Foijer, F., Jan-2018, In : BioEssays. 40, 1, 9 p., 1700147.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Schukken, K. M., & Foijer, F. (2018). CIN and Aneuploidy: Different Concepts, Different Consequences. BioEssays, 40(1), [1700147]. https://doi.org/10.1002/bies.201700147

Author

Schukken, Klaske M. ; Foijer, Floris. / CIN and Aneuploidy : Different Concepts, Different Consequences. In: BioEssays. 2018 ; Vol. 40, No. 1.

Harvard

Schukken, KM & Foijer, F 2018, 'CIN and Aneuploidy: Different Concepts, Different Consequences', BioEssays, vol. 40, no. 1, 1700147. https://doi.org/10.1002/bies.201700147

Standard

CIN and Aneuploidy : Different Concepts, Different Consequences. / Schukken, Klaske M.; Foijer, Floris.

In: BioEssays, Vol. 40, No. 1, 1700147, 01.2018.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Schukken KM, Foijer F. CIN and Aneuploidy: Different Concepts, Different Consequences. BioEssays. 2018 Jan;40(1). 1700147. https://doi.org/10.1002/bies.201700147


BibTeX

@article{64ac38c29dd14b07b34e5e73af286c71,
title = "CIN and Aneuploidy: Different Concepts, Different Consequences",
abstract = "Chromosomal instability (CIN) and aneuploidy are similar concepts but not synonymous. CIN is the process that leads to chromosome copy number alterations, and aneuploidy is the result. While CIN and resulting aneuploidy often cause growth defects, they are also selected for in cancer cells. Although such contradicting fates may seem paradoxical at first, they can be better understood when CIN and aneuploidy are assessed separately, taking into account the in vitro or in vivo context, the rate of CIN, and severity of the aneuploid karyotype. As CIN can only be measured in living cells, which proves to be technically challenging in vivo, aneuploidy is more frequently quantified. However, CIN rates might be more predictive for tumor outcome than assessing aneuploidy rates alone. In reviewing the literature, we therefore conclude that there is an urgent need for new models in which we can monitor chromosome mis-segregation and its consequences in vivo.",
keywords = "aging, aneuploidy, cancer, CIN, in vitro, in vivo, EMBRYONIC STEM-CELLS, AGING-ASSOCIATED PHENOTYPES, CHROMOSOME INSTABILITY, MAMMALIAN-CELLS, SINGLE-CELL, IN-VIVO, CONSTITUTIONAL ANEUPLOIDY, CENTROSOME AMPLIFICATION, BUBR1 INSUFFICIENCY, GENOMIC INSTABILITY",
author = "Schukken, {Klaske M.} and Floris Foijer",
note = "{\textcopyright} 2017 WILEY Periodicals, Inc.",
year = "2018",
month = jan,
doi = "10.1002/bies.201700147",
language = "English",
volume = "40",
journal = "BioEssays",
issn = "1521-1878",
publisher = "Wiley",
number = "1",

}

RIS

TY - JOUR

T1 - CIN and Aneuploidy

T2 - Different Concepts, Different Consequences

AU - Schukken, Klaske M.

AU - Foijer, Floris

N1 - © 2017 WILEY Periodicals, Inc.

PY - 2018/1

Y1 - 2018/1

N2 - Chromosomal instability (CIN) and aneuploidy are similar concepts but not synonymous. CIN is the process that leads to chromosome copy number alterations, and aneuploidy is the result. While CIN and resulting aneuploidy often cause growth defects, they are also selected for in cancer cells. Although such contradicting fates may seem paradoxical at first, they can be better understood when CIN and aneuploidy are assessed separately, taking into account the in vitro or in vivo context, the rate of CIN, and severity of the aneuploid karyotype. As CIN can only be measured in living cells, which proves to be technically challenging in vivo, aneuploidy is more frequently quantified. However, CIN rates might be more predictive for tumor outcome than assessing aneuploidy rates alone. In reviewing the literature, we therefore conclude that there is an urgent need for new models in which we can monitor chromosome mis-segregation and its consequences in vivo.

AB - Chromosomal instability (CIN) and aneuploidy are similar concepts but not synonymous. CIN is the process that leads to chromosome copy number alterations, and aneuploidy is the result. While CIN and resulting aneuploidy often cause growth defects, they are also selected for in cancer cells. Although such contradicting fates may seem paradoxical at first, they can be better understood when CIN and aneuploidy are assessed separately, taking into account the in vitro or in vivo context, the rate of CIN, and severity of the aneuploid karyotype. As CIN can only be measured in living cells, which proves to be technically challenging in vivo, aneuploidy is more frequently quantified. However, CIN rates might be more predictive for tumor outcome than assessing aneuploidy rates alone. In reviewing the literature, we therefore conclude that there is an urgent need for new models in which we can monitor chromosome mis-segregation and its consequences in vivo.

KW - aging

KW - aneuploidy

KW - cancer

KW - CIN

KW - in vitro

KW - in vivo

KW - EMBRYONIC STEM-CELLS

KW - AGING-ASSOCIATED PHENOTYPES

KW - CHROMOSOME INSTABILITY

KW - MAMMALIAN-CELLS

KW - SINGLE-CELL

KW - IN-VIVO

KW - CONSTITUTIONAL ANEUPLOIDY

KW - CENTROSOME AMPLIFICATION

KW - BUBR1 INSUFFICIENCY

KW - GENOMIC INSTABILITY

U2 - 10.1002/bies.201700147

DO - 10.1002/bies.201700147

M3 - Review article

C2 - 29160563

VL - 40

JO - BioEssays

JF - BioEssays

SN - 1521-1878

IS - 1

M1 - 1700147

ER -

ID: 50360591