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CIN and Aneuploidy: Different Concepts, Different Consequences

Schukken, K. M. & Foijer, F., Jan-2018, In : BioEssays. 40, 1, 9 p., 1700147.

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  • CIN and Aneuploidy

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DOI

Chromosomal instability (CIN) and aneuploidy are similar concepts but not synonymous. CIN is the process that leads to chromosome copy number alterations, and aneuploidy is the result. While CIN and resulting aneuploidy often cause growth defects, they are also selected for in cancer cells. Although such contradicting fates may seem paradoxical at first, they can be better understood when CIN and aneuploidy are assessed separately, taking into account the in vitro or in vivo context, the rate of CIN, and severity of the aneuploid karyotype. As CIN can only be measured in living cells, which proves to be technically challenging in vivo, aneuploidy is more frequently quantified. However, CIN rates might be more predictive for tumor outcome than assessing aneuploidy rates alone. In reviewing the literature, we therefore conclude that there is an urgent need for new models in which we can monitor chromosome mis-segregation and its consequences in vivo.

Original languageEnglish
Article number1700147
Number of pages9
JournalBioEssays
Volume40
Issue number1
Publication statusPublished - Jan-2018

    Keywords

  • aging, aneuploidy, cancer, CIN, in vitro, in vivo, EMBRYONIC STEM-CELLS, AGING-ASSOCIATED PHENOTYPES, CHROMOSOME INSTABILITY, MAMMALIAN-CELLS, SINGLE-CELL, IN-VIVO, CONSTITUTIONAL ANEUPLOIDY, CENTROSOME AMPLIFICATION, BUBR1 INSUFFICIENCY, GENOMIC INSTABILITY

ID: 50360591