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Chronic stress-induced changes in the rat brain: Role of sex differences and effects of long-term tianeptine treatment

Kuipers, S. D., Trentani, A., van der Zee, E. A. & den Boer, J. A., Dec-2013, In : Neuropharmacology. 75, p. 426-436 11 p.

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DOI

Growing evidence suggests neuroplasticity changes are pivotal in both the occurrence and treatment of affective disorders. Abnormal expression and/or phosphorylation of numerous plasticity-related proteins have been observed in depression, while prolonged antidepressant treatment has been associated with the attenuation of stress-mediated effects on dendritic remodeling and adult hippocampal neurogenesis in experimental animals. This study explores the neurobiological adaptations induced by chronic stress and/or long-term tianeptine treatment. Male and female rats were studied to determine the potential contributory role of sex differences on stress-induced pathology and antidepressant-mediated actions. Our results confirm chronic stress-induced HPA axis disturbance and neuroplasticity impairment in both sexes (i.e. reduced CREB phosphorylation and hippocampal BrdU labeling). Commonly ensuing neurobiological alterations were accompanied by unique sex-specific adaptations. When the antidepressant tianeptine was administered, HPA axis hyperactivity was attenuated and specific neuronal defects were ameliorated in both sexes. These findings provide novel insight into sex-related influences on the neurobiological substrates mediating chronic stress-induced actions on neuroplasticity and the mechanisms underlying tianeptine-mediated therapeutic effects. (C) 2013 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)426-436
Number of pages11
JournalNeuropharmacology
Volume75
Publication statusPublished - Dec-2013

    Keywords

  • BrdU, Chronic stress, CREB phosphorylation, FOS expression, Sex differences, Tianeptine, CHRONIC ANTIDEPRESSANT TREATMENT, ADULT HIPPOCAMPAL NEUROGENESIS, C-FOS EXPRESSION, FEMALE RAT, GLUCOCORTICOID-RECEPTOR, CELL-PROLIFERATION, PREFRONTAL CORTEX, RESTRAINT STRESS, GENE-EXPRESSION, MOOD DISORDERS

ID: 2391531