Chronic stress-induced changes in the rat brain: Role of sex differences and effects of long-term tianeptine treatmentKuipers, S. D., Trentani, A., van der Zee, E. A. & den Boer, J. A., Dec-2013, In : Neuropharmacology. 75, p. 426-436 11 p.
Research output: Contribution to journal › Article › Academic › peer-review
Growing evidence suggests neuroplasticity changes are pivotal in both the occurrence and treatment of affective disorders. Abnormal expression and/or phosphorylation of numerous plasticity-related proteins have been observed in depression, while prolonged antidepressant treatment has been associated with the attenuation of stress-mediated effects on dendritic remodeling and adult hippocampal neurogenesis in experimental animals. This study explores the neurobiological adaptations induced by chronic stress and/or long-term tianeptine treatment. Male and female rats were studied to determine the potential contributory role of sex differences on stress-induced pathology and antidepressant-mediated actions. Our results confirm chronic stress-induced HPA axis disturbance and neuroplasticity impairment in both sexes (i.e. reduced CREB phosphorylation and hippocampal BrdU labeling). Commonly ensuing neurobiological alterations were accompanied by unique sex-specific adaptations. When the antidepressant tianeptine was administered, HPA axis hyperactivity was attenuated and specific neuronal defects were ameliorated in both sexes. These findings provide novel insight into sex-related influences on the neurobiological substrates mediating chronic stress-induced actions on neuroplasticity and the mechanisms underlying tianeptine-mediated therapeutic effects. (C) 2013 Elsevier Ltd. All rights reserved.
|Number of pages||11|
|Publication status||Published - Dec-2013|
- BrdU, Chronic stress, CREB phosphorylation, FOS expression, Sex differences, Tianeptine, CHRONIC ANTIDEPRESSANT TREATMENT, ADULT HIPPOCAMPAL NEUROGENESIS, C-FOS EXPRESSION, FEMALE RAT, GLUCOCORTICOID-RECEPTOR, CELL-PROLIFERATION, PREFRONTAL CORTEX, RESTRAINT STRESS, GENE-EXPRESSION, MOOD DISORDERS