Publication

Chronic dietary changes in n-6/n-3 polyunsaturated fatty acid ratios cause developmental delay and reduce social interest in mice

van Elst, K., Brouwers, J. F., Merkens, J. E., Broekhoven, M. H., Birtoli, B., Helms, J. B. & Kas, M. J. H., Jan-2019, In : European Neuropsychopharmacology. 29, 1, p. 16-31 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

van Elst, K., Brouwers, J. F., Merkens, J. E., Broekhoven, M. H., Birtoli, B., Helms, J. B., & Kas, M. J. H. (2019). Chronic dietary changes in n-6/n-3 polyunsaturated fatty acid ratios cause developmental delay and reduce social interest in mice. European Neuropsychopharmacology, 29(1), 16-31. https://doi.org/10.1016/j.euroneuro.2018.11.1106

Author

van Elst, Kim ; Brouwers, Jos F. ; Merkens, Jessica E. ; Broekhoven, Mark H. ; Birtoli, Barbara ; Helms, J. Bernd ; Kas, Martien J. H. / Chronic dietary changes in n-6/n-3 polyunsaturated fatty acid ratios cause developmental delay and reduce social interest in mice. In: European Neuropsychopharmacology. 2019 ; Vol. 29, No. 1. pp. 16-31.

Harvard

van Elst, K, Brouwers, JF, Merkens, JE, Broekhoven, MH, Birtoli, B, Helms, JB & Kas, MJH 2019, 'Chronic dietary changes in n-6/n-3 polyunsaturated fatty acid ratios cause developmental delay and reduce social interest in mice', European Neuropsychopharmacology, vol. 29, no. 1, pp. 16-31. https://doi.org/10.1016/j.euroneuro.2018.11.1106

Standard

Chronic dietary changes in n-6/n-3 polyunsaturated fatty acid ratios cause developmental delay and reduce social interest in mice. / van Elst, Kim; Brouwers, Jos F.; Merkens, Jessica E.; Broekhoven, Mark H.; Birtoli, Barbara; Helms, J. Bernd; Kas, Martien J. H.

In: European Neuropsychopharmacology, Vol. 29, No. 1, 01.2019, p. 16-31.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

van Elst K, Brouwers JF, Merkens JE, Broekhoven MH, Birtoli B, Helms JB et al. Chronic dietary changes in n-6/n-3 polyunsaturated fatty acid ratios cause developmental delay and reduce social interest in mice. European Neuropsychopharmacology. 2019 Jan;29(1):16-31. https://doi.org/10.1016/j.euroneuro.2018.11.1106


BibTeX

@article{3d8f55d1a270461a875d4bdbfff92296,
title = "Chronic dietary changes in n-6/n-3 polyunsaturated fatty acid ratios cause developmental delay and reduce social interest in mice",
abstract = "Polyunsaturated fatty acids (PUFAs) are one of the main cellular building blocks, and dietary changes in PUFA composition are proposed as a potential route to influence brain development. For example, initial studies indicated that there is a relation between blood omega-6(n-6)/omega-3(n-3) PUFA ratios and neurodevelopmental disease diagnosis. To study the consequences of dietary n-6/n-3 PUFA ratio changes, we investigated the impact of a n-3 supplemented and n-3 deficient diet in developing BTBR T + Itpr3tf/J (BTBR) – a mouse inbred strain displaying Autism Spectrum Disorder (ASD)-like symptomatology - and control C57BL/6J mice. This study showed that pre- and postnatal changed dietary n-6/n-3 ratio intake has a major impact on blood and brain PUFA composition, and led to delayed physical development and puberty onset in both strains. The PUFA induced developmental delay did not impact adult cognitive performance, but resulted in reduced social interest, a main ASD behavioral feature. Thus, both chronic dietary n-3 PUFA supplementation and depletion may not be beneficial.",
keywords = "Autism Spectrum Disorder, Polyunsaturated fatty acids, Developmental delay, Omega-3, Mouse behavior",
author = "{van Elst}, Kim and Brouwers, {Jos F.} and Merkens, {Jessica E.} and Broekhoven, {Mark H.} and Barbara Birtoli and Helms, {J. Bernd} and Kas, {Martien J. H.}",
year = "2019",
month = "1",
doi = "10.1016/j.euroneuro.2018.11.1106",
language = "English",
volume = "29",
pages = "16--31",
journal = "European Neuropsychopharmacology",
issn = "0924-977X",
publisher = "ELSEVIER SCIENCE BV",
number = "1",

}

RIS

TY - JOUR

T1 - Chronic dietary changes in n-6/n-3 polyunsaturated fatty acid ratios cause developmental delay and reduce social interest in mice

AU - van Elst, Kim

AU - Brouwers, Jos F.

AU - Merkens, Jessica E.

AU - Broekhoven, Mark H.

AU - Birtoli, Barbara

AU - Helms, J. Bernd

AU - Kas, Martien J. H.

PY - 2019/1

Y1 - 2019/1

N2 - Polyunsaturated fatty acids (PUFAs) are one of the main cellular building blocks, and dietary changes in PUFA composition are proposed as a potential route to influence brain development. For example, initial studies indicated that there is a relation between blood omega-6(n-6)/omega-3(n-3) PUFA ratios and neurodevelopmental disease diagnosis. To study the consequences of dietary n-6/n-3 PUFA ratio changes, we investigated the impact of a n-3 supplemented and n-3 deficient diet in developing BTBR T + Itpr3tf/J (BTBR) – a mouse inbred strain displaying Autism Spectrum Disorder (ASD)-like symptomatology - and control C57BL/6J mice. This study showed that pre- and postnatal changed dietary n-6/n-3 ratio intake has a major impact on blood and brain PUFA composition, and led to delayed physical development and puberty onset in both strains. The PUFA induced developmental delay did not impact adult cognitive performance, but resulted in reduced social interest, a main ASD behavioral feature. Thus, both chronic dietary n-3 PUFA supplementation and depletion may not be beneficial.

AB - Polyunsaturated fatty acids (PUFAs) are one of the main cellular building blocks, and dietary changes in PUFA composition are proposed as a potential route to influence brain development. For example, initial studies indicated that there is a relation between blood omega-6(n-6)/omega-3(n-3) PUFA ratios and neurodevelopmental disease diagnosis. To study the consequences of dietary n-6/n-3 PUFA ratio changes, we investigated the impact of a n-3 supplemented and n-3 deficient diet in developing BTBR T + Itpr3tf/J (BTBR) – a mouse inbred strain displaying Autism Spectrum Disorder (ASD)-like symptomatology - and control C57BL/6J mice. This study showed that pre- and postnatal changed dietary n-6/n-3 ratio intake has a major impact on blood and brain PUFA composition, and led to delayed physical development and puberty onset in both strains. The PUFA induced developmental delay did not impact adult cognitive performance, but resulted in reduced social interest, a main ASD behavioral feature. Thus, both chronic dietary n-3 PUFA supplementation and depletion may not be beneficial.

KW - Autism Spectrum Disorder

KW - Polyunsaturated fatty acids

KW - Developmental delay

KW - Omega-3

KW - Mouse behavior

U2 - 10.1016/j.euroneuro.2018.11.1106

DO - 10.1016/j.euroneuro.2018.11.1106

M3 - Article

VL - 29

SP - 16

EP - 31

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

SN - 0924-977X

IS - 1

ER -

ID: 73706947