Chromosomal Changes in Mature Residual Teratomas following Polychemotherapy

Castedo, S. M. M. J., de Jong, B., Oosterhuis, J. W., Idenburg, V. J. S., Seruca, R., Buist, J., te Meerman, G. J., Schraffordt Koops, H. & Sleijfer, D. T., 1-Feb-1989, In : Cancer Research. 49, 3, p. 672-676 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • S M M J Castedo
  • B de Jong
  • J Wolter Oosterhuis
  • Vera J S Idenburg
  • Raquel Seruca
  • J Buist
  • Gerard J te Meerman
  • Heimen Schraffordt Koops
  • Dirk Th Sleijfer
A cytogenetic analysis of 13 mature residual teratomas following chemotherapy revealed modal chromosome numbers ranging from 52 to 85, in agreement with the flow cytometric determination of the DNA content of the tumors. At least one copy of an i(12p) was present in 12 tumors. One tumor, however, lacked that marker.

The comparison between the chromosomal abnormalities found in mature residual teratomas following chemotherapy and those from primary testicular nonseminomas suggests that residual teratomas result from selection of clones from the primary tumor with a less abnormal karyotype
Original languageEnglish
Pages (from-to)672-676
Number of pages5
JournalCancer Research
Issue number3
Publication statusPublished - 1-Feb-1989

ID: 6248148