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Cholesterol profile in women with premature menopause after risk reducing salpingo-oophorectomy

Teixeira, N., Mourits, M. J., Oosterwijk, J. C., Fakkert, I. E., Absalom, A. R., Bakker, S. J. L., van der Meer, P. & de Bock, G. H., Jan-2019, In : Familial Cancer. 18, 1, p. 19-27 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

This cross-sectional study aimed to investigate the effect of premenopausal risk reducing salpingo-oophorectomy (RRSO) on the cholesterol profile of women at increased ovarian cancer risk and to assess possible effects of age at and time since RRSO. We included 207 women who underwent RRSO before menopausal age (52years) attending the family cancer clinic of an academic hospital and 828 age-matched women from a general population cohort (PREVEND). Participants filled out a questionnaire on socio-demographic characteristics, lifestyle and medical history, had anthropometric measurements and provided blood samples for assessment of serum levels of total cholesterol, HDL-cholesterol and non-HDL-cholesterol. The correlation between RRSO and cholesterol profile was assessed with logistic regression. Furthermore, subgroup analyses were performed to explore a possible effect of age at and time since RRSO. At a median time of 5.9years (range 2.3-25.2) after surgery, RRSO was associated with low (

Original languageEnglish
Pages (from-to)19-27
Number of pages9
JournalFamilial Cancer
Volume18
Issue number1
Early online date7-Jun-2018
Publication statusPublished - Jan-2019

    Keywords

  • BRCA1, BRCA2, Risk reducing salpingo-oophorectomy, Cholesterol, Dyslipidemia, CORONARY-HEART-DISEASE, CARDIOVASCULAR-DISEASE, METABOLIC SYNDROME, BREAST, DENSITY, AGE, CHEMOTHERAPY, METAANALYSIS, REDUCTION, CARRIERS

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