Childhood-onset growth hormone deficiency, cognitive function and brain N-acetylaspartate

van Dam, PS., de Winter, CF., de Vries, R., van der Grond, J., Drent, ML., Lijffijt, M., Kenemans, JL., Aleman, A., de Haan, EHF. & Koppeschaar, HPF., May-2005, In : Psychoneuroendocrinology. 30, 4, p. 357-363 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • PS van Dam
  • CF de Winter
  • R de Vries
  • J van der Grond
  • ML Drent
  • M Lijffijt
  • JL Kenemans
  • A Aleman
  • EHF de Haan
  • HPF Koppeschaar

Cognitive deficits have been reported in adults with childhood-onset growth hormone (GH) deficiency. We evaluated cognitive deficits simultaneously with parameters for neuronal integrity using H-1 magnetic resonance spectroscopy (MRS) in a cross-sectional design. We studied 11 adults (mean age 24.5 years) with childhood-onset GH deficiency, which persisted after reaching final height. All subjects were evaluated after interruption of GH supplementation for at least 3 months. We performed neuropsychological assessment (NPA) using tests evaluating memory, mental processing speed, reading ability and executive functioning. MRS was used to assess brain N-acetylaspartate (NAA)/choline ratios. Data were compared with an age-, sex- and education-matched control group (n=9, mean age 27.3 years). NPA demonstrated attenuated performance of the patients in the delayed verbal memory recall score (P

Original languageEnglish
Pages (from-to)357-363
Number of pages7
Issue number4
Publication statusPublished - May-2005


  • growth hormone deficiency, cognitive function, N-acetylaspartate, neuronal integrity, QUALITY-OF-LIFE, PSYCHOLOGICAL CAPABILITIES, GH DEFICIENCY, WHITE-MATTER, AGE, RECEPTOR, ADULTS, SUBSTITUTION, EXPRESSION, DISORDERS

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