Publication

Childhood trauma and HPA axis functionality in offspring of bipolar parents

Schreuder, M. M., Vinkers, C. H., Mesman, E., Claes, S., Nolen, W. A. & Hillegers, M. H. J., Dec-2016, In : Psychoneuroendocrinology. 74, p. 316-323 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Schreuder, M. M., Vinkers, C. H., Mesman, E., Claes, S., Nolen, W. A., & Hillegers, M. H. J. (2016). Childhood trauma and HPA axis functionality in offspring of bipolar parents. Psychoneuroendocrinology, 74, 316-323. https://doi.org/10.1016/j.psyneuen.2016.09.017

Author

Schreuder, Merel M. ; Vinkers, Christiaan H. ; Mesman, Esther ; Claes, Stephan ; Nolen, Willem A. ; Hillegers, Manon H. J. / Childhood trauma and HPA axis functionality in offspring of bipolar parents. In: Psychoneuroendocrinology. 2016 ; Vol. 74. pp. 316-323.

Harvard

Schreuder, MM, Vinkers, CH, Mesman, E, Claes, S, Nolen, WA & Hillegers, MHJ 2016, 'Childhood trauma and HPA axis functionality in offspring of bipolar parents', Psychoneuroendocrinology, vol. 74, pp. 316-323. https://doi.org/10.1016/j.psyneuen.2016.09.017

Standard

Childhood trauma and HPA axis functionality in offspring of bipolar parents. / Schreuder, Merel M.; Vinkers, Christiaan H.; Mesman, Esther; Claes, Stephan; Nolen, Willem A.; Hillegers, Manon H. J.

In: Psychoneuroendocrinology, Vol. 74, 12.2016, p. 316-323.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Schreuder MM, Vinkers CH, Mesman E, Claes S, Nolen WA, Hillegers MHJ. Childhood trauma and HPA axis functionality in offspring of bipolar parents. Psychoneuroendocrinology. 2016 Dec;74:316-323. https://doi.org/10.1016/j.psyneuen.2016.09.017


BibTeX

@article{ec221d4a80704c3caf289739d20fd204,
title = "Childhood trauma and HPA axis functionality in offspring of bipolar parents",
abstract = "Children of a parent with bipolar disorder (bipolar offspring) have an increased risk for mood disorders. While genetic factors play a significant role in this population, susceptibility to environmental stress may also significantly contribute to this vulnerability for mood disorders. Childhood trauma has consistently been found to increase the risk for mood disorders, with persisting consequences for hypothalamic pituitary -adrenal (HPA) axis functionality. However, it is currently unknown whether childhood trauma specifically affects HPA axis activity in individuals with a familial risk for bipolar disorder. Therefore, we investigated the effects of childhood trauma on daytime and evening cortisol levels and dexamethasone suppression in bipolar offspring (N = 70) and healthy controls (N = 44). In our study we found no significant differences in daytime and evening cortisol levels as well as dexamethasone suppression between bipolar offspring and healthy controls (all p-values > 0.43). In contrast, childhood trauma differentially affected daytime cortisol levels in the bipolar offspring compared to healthy controls (childhood trauma X bipolar offspring interaction, beta = 7.310, p =0.0414) with an effect of childhood trauma on daytime cortisol in bipolar offspring at trend level (p =0.058). In the bipolar offspring group, lifetime or current psychiatric diagnoses, and stressful life events separately did not affect cortisol levels or dexamethasone suppression (all p-values > p = 0.50). These findings were independent of current or lifetime psychiatric diagnosis. In conclusion, trauma-related changes in daytime HPA axis activity appear to be a specific trait in bipolar offspring who have increased risk for mood disorders compared to healthy individuals. (C) 2016 Published by Elsevier Ltd.",
keywords = "HPA axis function, Dexamethasone suppression test, Childhood trauma, Life events, Bipolar disorder, CORTISOL AWAKENING RESPONSE, STRESSFUL LIFE EVENTS, HIGH-RISK, MAJOR DEPRESSION, STAGING MODEL, PSYCHIATRIC-DISORDERS, DAYTIME CORTISOL, MOOD-DISORDERS, GENETIC RISK, CHILDREN",
author = "Schreuder, {Merel M.} and Vinkers, {Christiaan H.} and Esther Mesman and Stephan Claes and Nolen, {Willem A.} and Hillegers, {Manon H. J.}",
year = "2016",
month = "12",
doi = "10.1016/j.psyneuen.2016.09.017",
language = "English",
volume = "74",
pages = "316--323",
journal = "Psychoneuroendocrinology",
issn = "0306-4530",
publisher = "PERGAMON-ELSEVIER SCIENCE LTD",

}

RIS

TY - JOUR

T1 - Childhood trauma and HPA axis functionality in offspring of bipolar parents

AU - Schreuder, Merel M.

AU - Vinkers, Christiaan H.

AU - Mesman, Esther

AU - Claes, Stephan

AU - Nolen, Willem A.

AU - Hillegers, Manon H. J.

PY - 2016/12

Y1 - 2016/12

N2 - Children of a parent with bipolar disorder (bipolar offspring) have an increased risk for mood disorders. While genetic factors play a significant role in this population, susceptibility to environmental stress may also significantly contribute to this vulnerability for mood disorders. Childhood trauma has consistently been found to increase the risk for mood disorders, with persisting consequences for hypothalamic pituitary -adrenal (HPA) axis functionality. However, it is currently unknown whether childhood trauma specifically affects HPA axis activity in individuals with a familial risk for bipolar disorder. Therefore, we investigated the effects of childhood trauma on daytime and evening cortisol levels and dexamethasone suppression in bipolar offspring (N = 70) and healthy controls (N = 44). In our study we found no significant differences in daytime and evening cortisol levels as well as dexamethasone suppression between bipolar offspring and healthy controls (all p-values > 0.43). In contrast, childhood trauma differentially affected daytime cortisol levels in the bipolar offspring compared to healthy controls (childhood trauma X bipolar offspring interaction, beta = 7.310, p =0.0414) with an effect of childhood trauma on daytime cortisol in bipolar offspring at trend level (p =0.058). In the bipolar offspring group, lifetime or current psychiatric diagnoses, and stressful life events separately did not affect cortisol levels or dexamethasone suppression (all p-values > p = 0.50). These findings were independent of current or lifetime psychiatric diagnosis. In conclusion, trauma-related changes in daytime HPA axis activity appear to be a specific trait in bipolar offspring who have increased risk for mood disorders compared to healthy individuals. (C) 2016 Published by Elsevier Ltd.

AB - Children of a parent with bipolar disorder (bipolar offspring) have an increased risk for mood disorders. While genetic factors play a significant role in this population, susceptibility to environmental stress may also significantly contribute to this vulnerability for mood disorders. Childhood trauma has consistently been found to increase the risk for mood disorders, with persisting consequences for hypothalamic pituitary -adrenal (HPA) axis functionality. However, it is currently unknown whether childhood trauma specifically affects HPA axis activity in individuals with a familial risk for bipolar disorder. Therefore, we investigated the effects of childhood trauma on daytime and evening cortisol levels and dexamethasone suppression in bipolar offspring (N = 70) and healthy controls (N = 44). In our study we found no significant differences in daytime and evening cortisol levels as well as dexamethasone suppression between bipolar offspring and healthy controls (all p-values > 0.43). In contrast, childhood trauma differentially affected daytime cortisol levels in the bipolar offspring compared to healthy controls (childhood trauma X bipolar offspring interaction, beta = 7.310, p =0.0414) with an effect of childhood trauma on daytime cortisol in bipolar offspring at trend level (p =0.058). In the bipolar offspring group, lifetime or current psychiatric diagnoses, and stressful life events separately did not affect cortisol levels or dexamethasone suppression (all p-values > p = 0.50). These findings were independent of current or lifetime psychiatric diagnosis. In conclusion, trauma-related changes in daytime HPA axis activity appear to be a specific trait in bipolar offspring who have increased risk for mood disorders compared to healthy individuals. (C) 2016 Published by Elsevier Ltd.

KW - HPA axis function

KW - Dexamethasone suppression test

KW - Childhood trauma

KW - Life events

KW - Bipolar disorder

KW - CORTISOL AWAKENING RESPONSE

KW - STRESSFUL LIFE EVENTS

KW - HIGH-RISK

KW - MAJOR DEPRESSION

KW - STAGING MODEL

KW - PSYCHIATRIC-DISORDERS

KW - DAYTIME CORTISOL

KW - MOOD-DISORDERS

KW - GENETIC RISK

KW - CHILDREN

U2 - 10.1016/j.psyneuen.2016.09.017

DO - 10.1016/j.psyneuen.2016.09.017

M3 - Article

VL - 74

SP - 316

EP - 323

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

SN - 0306-4530

ER -

ID: 39657436