Publication

Characterisation of jet-milled and spray dried isoniazid for pulmonary administration

Sibum, I., Grasmeijer, F., Hagedoorn, P. & Frijlink, H. W., Aug-2017, In : Journal of aerosol medicine and pulmonary drug delivery. 30, 4, p. A2 1 p.

Research output: Contribution to journalMeeting AbstractAcademic

APA

Sibum, I., Grasmeijer, F., Hagedoorn, P., & Frijlink, H. W. (2017). Characterisation of jet-milled and spray dried isoniazid for pulmonary administration. Journal of aerosol medicine and pulmonary drug delivery, 30(4), A2.

Author

Sibum, I. ; Grasmeijer, F. ; Hagedoorn, P. ; Frijlink, H. W. / Characterisation of jet-milled and spray dried isoniazid for pulmonary administration. In: Journal of aerosol medicine and pulmonary drug delivery. 2017 ; Vol. 30, No. 4. pp. A2.

Harvard

Sibum, I, Grasmeijer, F, Hagedoorn, P & Frijlink, HW 2017, 'Characterisation of jet-milled and spray dried isoniazid for pulmonary administration', Journal of aerosol medicine and pulmonary drug delivery, vol. 30, no. 4, pp. A2.

Standard

Characterisation of jet-milled and spray dried isoniazid for pulmonary administration. / Sibum, I.; Grasmeijer, F.; Hagedoorn, P.; Frijlink, H. W.

In: Journal of aerosol medicine and pulmonary drug delivery, Vol. 30, No. 4, 08.2017, p. A2.

Research output: Contribution to journalMeeting AbstractAcademic

Vancouver

Sibum I, Grasmeijer F, Hagedoorn P, Frijlink HW. Characterisation of jet-milled and spray dried isoniazid for pulmonary administration. Journal of aerosol medicine and pulmonary drug delivery. 2017 Aug;30(4):A2.


BibTeX

@article{7eacdd39af524965a38533098138f0a4,
title = "Characterisation of jet-milled and spray dried isoniazid for pulmonary administration",
abstract = "The aim of this study was to develop a dry powder isoniazid formulation with no or a limited amount of excipients for pulmonary administration. Milled isoniazid showed an excellent particle size distribution for inhalation, however dispersion was poor. In 78{\%} of the dispersion measurements the inhaler blocked, retaining most of its dose. Pure spray dried isoniazid yielded particles too large for pulmonary delivery, but the addition of 5{\%} of L-leucine resulted in spray dried particles of inhalable size. DSC data showed complete crystallinity for all samples, while TGA analysis showed that isoniazid sublimates around 100°C. SEM imaging showed that pure jet milled and spray dried isoniazid particles fused together. Isoniazid spray dried with L-leucine resulted in spherical particles with no fusion visible. The most likely explanation for particle fusion is that isoniazid crystalizes, resulting in solid bridge formation. L-leucine however, forms a coating around isoniazid particles, thereby preventing this phenomenon. Further experiments are needed to show why isoniazid fuses together in the jet mill. A possible explanation is that some isoniazid sublimates due to heat generation during particle collisions, and causes solid bridge formation between particles when it ripens. Further experiments have to show whether isoniazid co-spray dried with L-leucine disperses efficiently and is stable over time.",
author = "I. Sibum and F. Grasmeijer and P. Hagedoorn and Frijlink, {H. W.}",
year = "2017",
month = "8",
language = "English",
volume = "30",
pages = "A2",
journal = "Journal of aerosol medicine and pulmonary drug delivery",
issn = "1941-2711",
publisher = "MARY ANN LIEBERT, INC",
number = "4",

}

RIS

TY - JOUR

T1 - Characterisation of jet-milled and spray dried isoniazid for pulmonary administration

AU - Sibum, I.

AU - Grasmeijer, F.

AU - Hagedoorn, P.

AU - Frijlink, H. W.

PY - 2017/8

Y1 - 2017/8

N2 - The aim of this study was to develop a dry powder isoniazid formulation with no or a limited amount of excipients for pulmonary administration. Milled isoniazid showed an excellent particle size distribution for inhalation, however dispersion was poor. In 78% of the dispersion measurements the inhaler blocked, retaining most of its dose. Pure spray dried isoniazid yielded particles too large for pulmonary delivery, but the addition of 5% of L-leucine resulted in spray dried particles of inhalable size. DSC data showed complete crystallinity for all samples, while TGA analysis showed that isoniazid sublimates around 100°C. SEM imaging showed that pure jet milled and spray dried isoniazid particles fused together. Isoniazid spray dried with L-leucine resulted in spherical particles with no fusion visible. The most likely explanation for particle fusion is that isoniazid crystalizes, resulting in solid bridge formation. L-leucine however, forms a coating around isoniazid particles, thereby preventing this phenomenon. Further experiments are needed to show why isoniazid fuses together in the jet mill. A possible explanation is that some isoniazid sublimates due to heat generation during particle collisions, and causes solid bridge formation between particles when it ripens. Further experiments have to show whether isoniazid co-spray dried with L-leucine disperses efficiently and is stable over time.

AB - The aim of this study was to develop a dry powder isoniazid formulation with no or a limited amount of excipients for pulmonary administration. Milled isoniazid showed an excellent particle size distribution for inhalation, however dispersion was poor. In 78% of the dispersion measurements the inhaler blocked, retaining most of its dose. Pure spray dried isoniazid yielded particles too large for pulmonary delivery, but the addition of 5% of L-leucine resulted in spray dried particles of inhalable size. DSC data showed complete crystallinity for all samples, while TGA analysis showed that isoniazid sublimates around 100°C. SEM imaging showed that pure jet milled and spray dried isoniazid particles fused together. Isoniazid spray dried with L-leucine resulted in spherical particles with no fusion visible. The most likely explanation for particle fusion is that isoniazid crystalizes, resulting in solid bridge formation. L-leucine however, forms a coating around isoniazid particles, thereby preventing this phenomenon. Further experiments are needed to show why isoniazid fuses together in the jet mill. A possible explanation is that some isoniazid sublimates due to heat generation during particle collisions, and causes solid bridge formation between particles when it ripens. Further experiments have to show whether isoniazid co-spray dried with L-leucine disperses efficiently and is stable over time.

M3 - Meeting Abstract

VL - 30

SP - A2

JO - Journal of aerosol medicine and pulmonary drug delivery

JF - Journal of aerosol medicine and pulmonary drug delivery

SN - 1941-2711

IS - 4

ER -

ID: 47537642