Changes in estrogen-alpha receptor immunoreactivity during the estrous cycle in lactating dairy cattle

van Eerdenburg, F. J., Daemen, I. A., van der Beek, E. M. & van Leeuwen, F. W., Oct-2000, In : Brain Research. 880, 1-2, p. 219-223 5 p.

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  • Changes in estrogen-α receptor immunoreactivity during the estrous cycle in lactating dairy cattle

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Estradiol is one of the most important hormones in the regulation of estrous behavior, which is at a very low level of expression in the modern dairy cow. In the present study the neuroanatomical distribution of estrogen receptors of the alpha-subtype (ER-alpha) in the bovine hypothalamic area is determined with immunocytochemical methods, at various stages of the estrous cycle. During the luteal phase of the cycle, ER-alpha immunoreactive cells were found in most of the nuclei that are known to express ER-alpha immunoreactivity in other species, like the Bed nucleus of the Stria terminalis, Medial preoptic area, Ventromedial hypothalamus and Arcuate nucleus. During estrus and metestrus, however, no ER-alpha immunoreactive cells could be detected in those areas, except for a few in the caudal Arcuate nucleus. The results from the present study indicate that there is a coherent regulation and timing of physiological and behavioral events around ovulation, in which estradiol and its receptor play a key role.

Original languageEnglish
Pages (from-to)219-223
Number of pages5
JournalBrain Research
Issue number1-2
Publication statusPublished - Oct-2000
Externally publishedYes


  • Animals, Arcuate Nucleus of Hypothalamus/physiology, Cattle, Estrogen Receptor alpha, Estrus/physiology, Female, Hypothalamus/cytology, Immunohistochemistry, Lactation/physiology, Neurons/cytology, Preoptic Area/physiology, Receptors, Estrogen/analysis, Ventromedial Hypothalamic Nucleus/physiology

ID: 119140416